4.4 Review

Current and Emerging Strategies to Inhibit Type 2 Inflammation in Atopic Dermatitis

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Summary: Global transcriptomic profiling using tape strips in early-onset pediatric AD reveals immune and barrier alterations in both lesional and nonlesional skin, with significant dysregulation of Th2 and Th22/Th17-related genes. This approach provides insight into disease pathomechanisms and cutaneous disease activity, highlighting the potential utility of tape strips in studying pediatric AD.

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Summary: This study utilized RNA-seq analysis of tape strips from lesional and nonlesional skin of patients with moderate-to-severe AD and psoriasis, revealing distinct immune and barrier signatures in the two diseases. The findings suggest the potential utility of tape strips as a minimally invasive alternative to biopsies for detecting disease biomarkers. Differences in gene expression profiles between AD and psoriasis highlight the unique pathophysiological mechanisms of these two skin disorders.

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Summary: The study demonstrates that tralokinumab in combination with TCS is effective and well tolerated in patients with moderate-to-severe AD; high dose tralokinumab showed superior efficacy compared to placebo at 16 weeks. Patients who continued tralokinumab treatment at week 32 maintained response. The overall incidence of adverse events was similar across treatment groups.

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