期刊
DERMATOLOGY AND THERAPY
卷 12, 期 4, 页码 861-869出版社
ADIS INT LTD
DOI: 10.1007/s13555-022-00699-w
关键词
Hematoporphyrin monomethyl ether; Photodynamic therapy; Port-wine stain; Adult Chinese patients
类别
资金
- Health Commission of Guangxi Autonomous Region of China [Z20201258, 2020GXNSFAA297150]
This study evaluated the clinical efficacy and treatment response of HMME-PDT in adult Chinese patients with port-wine stains (PWSs). The results showed that HMME-PDT is an effective and safe treatment for purple PWSs, and multiple treatments can improve the cure rate.
Introduction Hematoporphyrin monomethyl ether-photodynamic therapy (HMME-PDT) has been showing promising results in the treatment of port-wine stains (PWSs). We evaluated the clinical efficacy and treatment response of HMME-PDT in adult Chinese patients with PWSs. Methods A single-center retrospective study recruited adult PWS patients with negative HMME skin test results from December 2017 to May 2020. Patients received an intravenous injection of 5 mg/kg HMME and the lesions were exposed to 532 nm LED green light with an irradiation power density of 85-95 mW/cm(2) for 20-25 min. Digital photographs were taken before and after two therapy sessions and observed by three blinded dermatologists for clinical response. Results A total of 72 patients aged between 18 and 55 years were recruited. There were 65 patients of the flat purple type, 5 of the hypertrophic type, and 2 of the nodular thickening type. Of the 65 patients, 7 showed excellent efficacy (10.77%), 13 patients indicated good efficacy (20.00%), 47 patients showed fair efficacy (64.62%), while 3 cases displayed no improvement (4.62%). All five patients of the purple and hypertrophic type showed fair efficacy (100%), and no improvement was observed in patients of the nodular thickening type (100%). Pain, pruritus, and a burning sensation were observed during treatment. Edema was noted on the treated areas post-treatment. No other obvious systemic adverse reactions were observed. Conclusion HMME-PDT is an effective and safe treatment for adult patients with purple PWSs. Multiple HMME-PDT treatments can improve the response and cure rate.
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