期刊
MICROORGANISMS
卷 10, 期 3, 页码 -出版社
MDPI
DOI: 10.3390/microorganisms10030491
关键词
long-read sequencing; bla(CTX-M-27); plasmid transfer
类别
资金
- Medical Faculty of the Westfalische Wilhelms University Munster (IMF) [SC 22 19 03]
- Open Access Publication Fund of the University of Munster
This study presents whole genome sequencing data of two multidrug resistant bacteria isolates, showing the horizontal plasmid exchange between the two species, which explains their correlated resistance phenotypes.
Plasmid transfer is one important mechanism how antimicrobial resistance can spread between different species, contributing to the rise of multidrug resistant bacteria (MDRB) worldwide. Here were present whole genome sequencing (WGS) data of two MDRB isolates, an Escherichia coli and a Klebsiella quasipneumoniae, which were isolated from a single patient. Detailed analysis of long-read sequencing data identified an identical F2:A-:B- lncFII plasmid containing bla(CTX-M-27) in both isolates, suggesting horizontal plasmid exchange between the two species. As the plasmid of the E. coli strain carried multiple copies of the resistance cassette, the genomic data correlated with the increased antimicrobial resistance (AMR) detected for this isolate. Our case report demonstrates how long-read sequencing data of MDRB can be used to investigate the role of plasmid mediate resistance in the healthcare setting and explain resistance phenotypes.
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