期刊
MICROORGANISMS
卷 10, 期 3, 页码 -出版社
MDPI
DOI: 10.3390/microorganisms10030525
关键词
Ornithodoros moubata; Borrelia duttonii; midgut transcriptome; differential gene expression analysis; Argasidae; relapsing-fever spirochetes
类别
资金
- Federal Ministry of Education and Research (BMBF, Germany) [01KI1804]
Studies on tick-pathogen-host interactions are important for identifying vaccine candidates and bioactive molecules against ticks and tick-borne diseases.
Studies on tick-pathogen-host interactions are helping to identify candidates for vaccines against ticks and tick-borne diseases and to discover potent bioactive tick molecules. The tick midgut is the main tissue involved in blood feeding and, moreover, the first organ to have contact with pathogens ingested through the blood meal. As little is known about the molecular biology of feeding and tick defence mechanisms against microorganisms, but important for understanding vector-pathogen interactions, we explored the early transcriptional changes in the midgut of Ornithodoros moubata after feeding and in response to challenge with the relapsing-fever spirochete Borrelia duttonii using the Ion S5XL platform. Besides transcripts with metabolic function and immune-related transcripts we discovered numerous putative and uncharacterized protein sequences. Overall, our analyses support previous studies and provides a valuable reference database for further functional proteomic analysis of midgut proteins of O. moubata.
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