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Article
Biochemistry & Molecular Biology
Cecylia S. Lupala et al.
Summary: The COVID-19 pandemic caused by SARS-CoV-2 virus has resulted in over 270 million infections and 5.3 million deaths worldwide. The emergence of the Omicron variant has raised concerns about reducing vaccine efficacy and neutralizing antibodies due to its numerous mutations. Analysis indicates that the Omicron variant binds more strongly to the human ACE2 protein, with mutations at the ACE2-RBD interface enhancing tight binding through increased hydrogen bonding interactions and enlarged buried solvent accessible surface area.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Letter
Microbiology
Joshua Deerain et al.
JOURNAL OF CLINICAL MICROBIOLOGY
(2022)
Article
Virology
Lulan Wang et al.
Summary: The discovery of the Omicron variant has sparked global concerns about its mutations, transmission, and immune escape properties. Current research suggests that the variant may impact viral infectivity and host immunity, and it may evolve from clade 20B.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Virology
Suresh Kumar et al.
Summary: The emergence of the new SARS-CoV-2 variant, Omicron, has raised concerns due to its potential high affinity for human ACE2, indicating a higher transmission potential. Compared to the Delta variant, Omicron has a significantly different amino acid composition and protein structure, which may affect its stability and ACE2 binding.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Virology
Shailendra K. Saxena et al.
Summary: Omicron is the latest variant of concern of SARS-CoV-2, with more mutations compared to the previous Delta variant. Fifteen of these mutations are located in the receptor-binding domain of the spike glycoprotein, which may affect transmissibility, infectivity, antibody neutralization, and vaccine efficacy. The study provides insights into the mutational hotspots of Omicron and its global impact on transmission, testing, and immunity.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Editorial Material
Medicine, General & Internal
Joshua Nealon et al.
Article
Medicine, General & Internal
Nicole Wolter et al.
Summary: According to data analysis from South Africa, individuals infected with the omicron variant have a lower likelihood of hospitalization compared to those infected with non-omicron variants. Furthermore, individuals infected with the omicron variant have a lower odds of severe disease compared to individuals infected with the earlier delta variant.
Article
Multidisciplinary Sciences
Elisabetta Cameroni et al.
Summary: The Omicron variant of SARS-CoV-2 has raised concerns due to its 37 amino acid substitutions in the spike protein, particularly in the receptor-binding domain (RBD), leading to increased binding affinity with human ACE2. Neutralizing activity against Omicron was greatly reduced in convalescent and vaccinated individuals compared to the ancestral virus, but this decrease was less significant after a third vaccine dose. Broadly neutralizing monoclonal antibodies recognizing conserved RBD epitopes may be crucial in combating the Omicron variant and future zoonotic transmissions.
Article
Multidisciplinary Sciences
Raquel Viana et al.
Summary: The SARS-CoV-2 epidemic in southern Africa has experienced three distinct waves, driven by different variants. The recently identified Omicron variant has rapidly spread in South Africa and to numerous countries, raising global concern.
Article
Multidisciplinary Sciences
Yunlong Cao et al.
Summary: The Omicron variant of SARS-CoV-2 contains 15 mutations in the receptor-binding domain, leading to evasion of over 85% of tested neutralizing antibodies. Different epitope groups of neutralizing antibodies are affected to varying degrees by single mutations of Omicron. Antibodies targeting the conserved region of sarbecovirus remain most effective against Omicron.
Article
Immunology
Jingwen Ai et al.
Summary: This study explored the immunogenicity of different vaccination strategies against the Omicron variant of SARS-CoV-2. The results showed that the Omicron variant has a high immune escape ability compared to other variants, but heterologous protein subunit vaccines and homologous inactivated vaccine boosters can improve neutralization against Omicron.
EMERGING MICROBES & INFECTIONS
(2022)
Letter
Infectious Diseases
Paula de Michelena et al.
JOURNAL OF INFECTION
(2022)
Article
Infectious Diseases
Eliseo Albert et al.
Summary: The Panbio (TM) COVID-19 Ag Rapid Test Device performed well as a POC test for early diagnosis of COVID-19 in primary healthcare centres, with a specificity and sensitivity of 100% and 79.6% respectively. The negative predictive value of RAD was 99% and 97.9% under estimated prevalence of 5% and 10% respectively.
CLINICAL MICROBIOLOGY AND INFECTION
(2021)
Article
Multidisciplinary Sciences
Sandile Cele et al.
News Item
Multidisciplinary Sciences
Ewen Callaway
Review
Microbiology
Nicholas Murgolo et al.
Summary: This article discusses the key molecular and cellular interactions involved in SARS-CoV-2 infection to support current and future drug discovery efforts. While there are currently no FDA-approved treatments for COVID-19, potential antiviral compounds have been identified through drug repurposing screens.
Editorial Material
Public, Environmental & Occupational Health
Catharina Boehme et al.
LANCET GLOBAL HEALTH
(2021)
Article
Infectious Diseases
Erik Boehm et al.
Summary: Many new variants of SARS-CoV-2 have been identified as variants of concern/interest due to increased transmissibility, severity, immune escape, and reduced vaccine efficacy. These variants often share similar mutations, such as N501Y and E484K, which lead to partial immune escape, decreased vaccine efficacy, and potentially increased severity.
CLINICAL MICROBIOLOGY AND INFECTION
(2021)
Article
Infectious Diseases
Terezinha Marta Pereira Pinto Castineiras et al.
Summary: The study demonstrated that the performance of the Novel RT-PCR method is acceptable compared to the SoC RT-PCR method and can be a useful tool to perform RT-PCR without the need for new swab collections.
BRAZILIAN JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Parasitology
Cassia Cristina Alves Goncalves et al.
Summary: Saliva may be considered as an alternative to NP swabs when not available or recommended, while gingival fluid swabs are not suitable substitutes for NP swabs.
MEMORIAS DO INSTITUTO OSWALDO CRUZ
(2021)
Article
Infectious Diseases
Victor M. Corman et al.
Letter
Medicine, General & Internal
Lirong Zou et al.
NEW ENGLAND JOURNAL OF MEDICINE
(2020)
