相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。
Review
Biochemistry & Molecular Biology
Mohammad Shah Alam et al.
Summary: The COVID-19 pandemic has presented unprecedented challenges to global health, with many patients developing severe disease and needing immediate hospitalization. Underlying comorbidities such as diabetes and obesity are associated with more severe infections. Elevated levels of reactive oxygen species (ROS) and oxidative stress contribute to the dysregulated immune response and pathogenesis of COVID-19. Understanding the mechanisms of oxidative stress and exploring preventive measures may help mitigate complications and decrease mortality.
CYTOKINE & GROWTH FACTOR REVIEWS
(2022)
Article
Infectious Diseases
Zainab Thanon Hasan et al.
Summary: This study suggests that the use of melatonin can reduce thrombosis, sepsis, and mortality rate in severe COVID-19 adult patients.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Review
Biochemistry & Molecular Biology
Joaquin Guerra et al.
Summary: In addition to genetic mutations, abnormal epigenetic changes play a crucial role in the development of head and neck cancer. Researchers are currently developing drugs, known as epidrugs, to correct these epigenetic alterations. Some compounds with antioxidant effects have been found to be effective in preventing malignant lesions and reducing complications from cytotoxic treatment. Studies have also shown promising results for certain compounds in the treatment of head and neck squamous cell carcinoma.
Article
Medicine, Research & Experimental
Gholamreza Farnoosh et al.
Summary: This study evaluated the clinical efficacy of melatonin as an adjuvant treatment for COVID-19 patients. The results showed that the use of melatonin significantly improved clinical symptoms, shortened hospital stay, and had no deaths or adverse events.
ARCHIVES OF MEDICAL RESEARCH
(2022)
Article
Virology
Seyed Abbas Mousavi et al.
Summary: The study found that the combination of oral melatonin tablets and standard treatment can significantly improve sleep quality and blood oxygen saturation in hospitalized COVID-19 patients, but there was no significant difference in symptom alleviation.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Review
Medicine, Research & Experimental
Dun-Xian Tan et al.
Summary: Melatonin, a potential drug for treating SARS-CoV-2 infection, can reduce inflammation and mortality by regulating the host immune response. Clinical trials have shown that adding melatonin to conventional therapy significantly reduces the mortality of severe COVID-19 patients. Melatonin has a low cost and high safety margin, making it an affordable treatment option for countries worldwide.
Article
Cell Biology
Donghui Yang et al.
Summary: Studies show that melatonin can inhibit endoplasmic reticulum stress and inflammatory response induced by lipopolysaccharide treatment, and repair testicular damage.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Yun Song et al.
Summary: Chloroplast plays a central role in photosynthesis and metabolism, and emerging as a crucial regulator in plant response to stress. Through gene expression and signal transduction, it interacts with the environment to help plants adapt to adverse conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Prapimpun Wongchitrat et al.
Summary: Viral infections can lead to neurological disorders by inducing oxidative stress and disrupting immune system function. Melatonin has been shown to have antiviral properties against viruses that cause neurological symptoms, thanks to its antioxidant, anti-inflammatory, and immunoregulatory properties as well as its neuroprotective effects.
Review
Biochemistry & Molecular Biology
Paula Fernandez-Palanca et al.
Summary: Melatonin, with antioxidant, chronobiotic, and anti-inflammatory properties, shows potential as a promising treatment option for liver cancers by modulating various processes such as inhibiting oxidative stress, promoting immune response, and inducing cell cycle arrest and apoptosis.
Review
Biochemistry & Molecular Biology
Olivia G. Camp et al.
Summary: Recent studies have found a correlation between COVID-19 and the cytokine storm, which leads to excessive production of reactive oxygen species. Melatonin, a potent MPO inhibitor, has been proposed as a therapeutic agent for COVID-19 due to its anti-inflammatory, anti-oxidative properties.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2021)
Review
Cell Biology
Milad Ashrafizadeh et al.
Summary: Melatonin, a hormone produced by the pineal gland, plays a crucial role in regulating physiological activities such as sleep and circadian rhythm. It possesses various pharmacological activities, including antioxidant, anti-inflammatory, and protective effects on the liver, heart, and nervous system. Studies have shown that melatonin exerts therapeutic efficacy in treating cancer and diabetes by affecting multiple molecular pathways.
Article
Biochemistry & Molecular Biology
Alejandro Gonzalez-Candia et al.
Summary: The study demonstrates that neonatal melatonin treatment has positive effects in reducing pulmonary arterial pressure, enhancing cardiac function, and decreasing oxidative stress. This treatment has the potential to provide cardioprotective effects for newborns suffering from developmental chronic hypoxia.
Review
Biotechnology & Applied Microbiology
Sangiliyandi Gurunathan et al.
Summary: Cancer is the second leading cause of death worldwide, and melatonin has been shown to have oncostatic and anticancer properties by directly affecting carcinogenesis and indirectly disrupting the circadian cycle.
ONCOTARGETS AND THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Matias Estaras et al.
Summary: Melatonin modulates oxidative state, cell viability, and expression of proinflammatory mediators in pancreatic stellate cells under hypoxia, demonstrating its potential therapeutic effects in pancreatic tumors.
Article
Biochemistry & Molecular Biology
Ramy K. A. Sayed et al.
Summary: The study found that aging increases the expression of certain miRs (miR-21, miR-146a, miR-223), while NLRP3 gene knockout helps improve muscle fiber arrangement and reduce collagen deposits. Melatonin significantly reduces the expression of certain miRs in aged mice.
Article
Biochemistry & Molecular Biology
Eui-Hyun Kim et al.
Summary: The study revealed that treatment with melatonin and phytanic acid enhances porcine embryonic development, while injecting Pex19-targeted siRNAs has the opposite effect. Additionally, melatonin and phytanic acid treatment upregulates peroxisomal activities, Nrf2 signaling, lipid metabolism, and mitochondrial membrane potentials.
Article
Biochemistry & Molecular Biology
Ana Guerra-Librero et al.
Summary: Melatonin induces a shift to aerobic mitochondrial metabolism in head and neck cancer cells, resulting in changes in mitochondrial morphology, function, fusion, and fission, increased oxidative phosphorylation, and inhibited glycolysis. This leads to increased ROS production, apoptosis, mitophagy, decreased cell proliferation, and suggests new molecular pathways involved in melatonin's anticancer activity. High doses of melatonin used for its cytotoxic effects may also impact HNSCC cells through melatonin receptors.
Article
Biochemistry & Molecular Biology
Hyoung Yool Lee et al.
Summary: Knockout of SNAT1 gene in Arabidopsis leads to smaller plant size, impaired growth, abnormal chloroplast protein quality control, and reduced starch accumulation. Melatonin is involved in regulating these processes, potentially mediated through the MAPK signaling cascade.
Review
Biochemistry & Molecular Biology
Adam Wichniak et al.
Summary: Melatonin shows potential benefits in treating sleep disturbances related to COVID-19, reducing the risk of viral entry into cells, decreasing inflammation, limiting tissue damage, and enhancing vaccine efficacy. Randomized clinical trials are needed to confirm its clinical usefulness.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Allergy
Zahra Alizadeh et al.
Summary: This study demonstrated the effectiveness of oral melatonin in controlling inflammation and promoting recovery in mild to moderate COVID-19 outpatients. Compared to the control group, the melatonin group showed significantly better levels of C-reactive protein and recovery rates.
IRANIAN JOURNAL OF ALLERGY ASTHMA AND IMMUNOLOGY
(2021)
Article
Neurosciences
Miao Qin et al.
Summary: The study found that melatonin can inhibit the overactivation of NLRP3 inflammasomes by enhancing mitochondrial autophagy and inhibiting TLR4/NF-κB pathway activity, thus alleviating white matter damage caused by endotoxin and ischemic hypoxia in neonatal rats.
Review
Cell Biology
Adriana Fodor et al.
Summary: The COVID-19 pandemic has caused over 3.4 million deaths worldwide and is caused by SARS-CoV-2, affecting not only the lungs but also the cardiovascular system. Clinical manifestations of COVID-19 vary widely, with severe cases leading to respiratory failure. Studies have shown that the severe lung damage associated with COVID-19 is related to both acute respiratory distress syndrome and vascular involvement.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Article
Pharmacology & Pharmacy
Esteban G. Figueroa et al.
Summary: The study found that melatonin can improve vasodilator function and increase the action and expression of vasodilatory prostanoids in PAHN, reducing the effects of vasoconstrictor prostanoids.
VASCULAR PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Eva Ramos et al.
Summary: Viral infections such as COVID-19 disrupt the host's physiology, prompting an immune response. Melatonin is a potential protective agent due to its antioxidant, anti-inflammatory, and immune-stimulant properties, which could combat the oxidative activity and excessive production of reactive oxygen and nitrogen species in the body. By enhancing host protection responses during critical phases of the infective cycle, melatonin may offer multi-protection against current and emerging virus variants circulating within the population.
Review
Biochemistry & Molecular Biology
Burak Ibrahim Arioz et al.
Summary: The NLRP3 inflammasome, as a part of the innate immune system, is associated with various diseases when overactivated; while melatonin, a natural product, can alleviate NLRP3 inflammasome activity by regulating intracellular signaling pathways.
Review
Cell Biology
Alessandra Stacchiotti et al.
Review
Virology
Kobra Bahrampour Juybari et al.
Article
Biochemistry & Molecular Biology
Victor Farre-Alins et al.
Article
Biochemistry & Molecular Biology
Shou-Long Deng et al.
Review
Medicine, Research & Experimental
Daniel P. Cardinali et al.
Review
Biochemistry & Molecular Biology
Nadia Ferlazzo et al.
Review
Cell Biology
Omid Reza Tamtaji et al.
JOURNAL OF CELLULAR PHYSIOLOGY
(2019)
Article
Food Science & Technology
Shing-Hwa Huang et al.
JOURNAL OF FUNCTIONAL FOODS
(2019)
Review
Cell Biology
Keywan Mortezaee
JOURNAL OF CELLULAR PHYSIOLOGY
(2018)
Review
Medicine, General & Internal
Thenappan Thenappan et al.
BMJ-BRITISH MEDICAL JOURNAL
(2018)
Review
Medicine, General & Internal
Thenappan Thenappan et al.
BMJ-BRITISH MEDICAL JOURNAL
(2018)
Review
Biochemistry & Molecular Biology
Barbara Pfister et al.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2016)
Review
Endocrinology & Metabolism
Russel J. Reiter et al.
JOURNAL OF PINEAL RESEARCH
(2016)
