期刊
ANTIOXIDANTS
卷 11, 期 4, 页码 -出版社
MDPI
DOI: 10.3390/antiox11040625
关键词
hyperthermia; cancer; combination therapy; chemotherapy; natural product; synergistic effect; reactive oxygen species; heat shock protein
资金
- National Research Foundation of Korea (NRF) - Korea government (MSIP) [NRF-2020R1I1A3063625]
Despite advancements in diagnosis and treatment, cancer remains a critical threat to health. Hyperthermia (HT) is a promising and cost-effective treatment strategy for cancer. This review summarizes studies on the anti-cancer effects of HT and its detailed mechanisms, as well as the combination therapies that can overcome the limitations of HT.
Despite recent developments in diagnosis and treatment options, cancer remains one of the most critical threats to health. Several anti-cancer therapies have been identified, but further research is needed to provide more treatment options that are safe and effective for cancer. Hyperthermia (HT) is a promising treatment strategy for cancer because of its safety and cost-effectiveness. This review summarizes studies on the anti-cancer effects of HT and the detailed mechanisms. In addition, combination therapies with anti-cancer drugs or natural products that can effectively overcome the limitations of HT are reviewed because HT may trigger protective events, such as an increase of heat shock proteins (HSPs). In the 115 reports included, the mechanisms related to apoptosis, cell cycle, reactive oxygen species, mitochondrial membrane potential, DNA damage, transcription factors and HSPs were considered important. This review shows that HT is an effective inducer of apoptosis. Moreover, the limitations of HT may be overcome using combined therapy with anti-cancer drugs or natural products. Therefore, appropriate combinations of such agents with HT will exert maximal effects to treat cancer.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据