4.7 Editorial Material

Comment on Yeste et al. Polyphenols and IUGR Pregnancies: Intrauterine Growth Restriction and Hydroxytyrosol Affect the Development and Neurotransmitter Profile of the Hippocampus in a Pig Model. Antioxidants 2021, 10, 1505 Comment

期刊

ANTIOXIDANTS
卷 11, 期 5, 页码 -

出版社

MDPI
DOI: 10.3390/antiox11050833

关键词

intrauterine growth restriction; hydroxytyrosol; tyrosol; supplementation; balanced diet; Mediterranean diet

资金

  1. Fondo de Investigaciones Sanitarias of the Instituto de Salud Carlos III (ISCIII) [PI1800451, PI1800498, PI2100935]
  2. Centro de Investigacion Biomedica en Red de Enfermedades Raras (CIBERER)
  3. Fundacio Privada Cellex
  4. ISCIII [CD21/00019]
  5. European Social Fund Plus (ESF+)
  6. FEDER

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This study found that dietary interventions, including supplementation with hydroxytyrosol, can improve complications of IUGR. Additionally, early biomarkers combined with dietary interventions may help predict IUGR diagnosis, aiding in avoiding risks of newborn mortality and morbidity.
Intrauterine growth restriction (IUGR) affects 5-10% of newborns and increases the risks of intrauterine demise, neonatal morbidity, and death. In their recent publication, Yeste et al. found the benefits of hydroxytyrosol supplementation on brain remodeling from an IUGR pig model. Additionally, we found a significant decrease in phenolic alcohol (tyrosol and hydroxytyrosol) intake in IUGR pregnant women. Altogether, these findings support the notion that dietetic interventions, through supplementation but mostly via a balanced diet, can ameliorate IUGR complications. Furthermore, diet intervention combined with early biomarkers may allow clinicians to eventually anticipate IUGR diagnosis and help avoid one of the most frequent causes of newborn mortality and morbidity.

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