期刊
ANTIOXIDANTS
卷 11, 期 3, 页码 -出版社
MDPI
DOI: 10.3390/antiox11030459
关键词
antibacterial resistance; curcumin; bacterial infection; molecular mechanism; nano-formulations
资金
- Guangdong Major Project of Basic and Applied Basic Research [2020B0301030007]
- National Natural Science Foundation of China [32102724]
Curcumin, an important component of turmeric, is considered a safe oral treatment for bacterial infections and has exhibited antibacterial activities against both Gram-negative and Gram-positive bacteria. Its antibacterial actions include disrupting bacterial membranes, inhibiting the production of bacterial virulence factors and biofilm formation, as well as inducing oxidative stress. Additionally, curcumin acts as a broad-spectrum antibacterial adjuvant, showing marked additive or synergistic effects with conventional antibiotics or non-antibiotic compounds.
The rapid spread of antibiotic resistance and lack of effective drugs for treating infections caused by multi-drug resistant bacteria in animal and human medicine have forced us to find new antibacterial strategies. Natural products have served as powerful therapeutics against bacterial infection and are still an important source for the discovery of novel antibacterial drugs. Curcumin, an important constituent of turmeric, is considered safe for oral consumption to treat bacterial infections. Many studies showed that curcumin exhibited antibacterial activities against Gram-negative and Gram-positive bacteria. The antibacterial action of curcumin involves the disruption of the bacterial membrane, inhibition of the production of bacterial virulence factors and biofilm formation, and the induction of oxidative stress. These characteristics also contribute to explain how curcumin acts a broad-spectrum antibacterial adjuvant, which was evidenced by the markedly additive or synergistical effects with various types of conventional antibiotics or non-antibiotic compounds. In this review, we summarize the antibacterial properties, underlying molecular mechanism of curcumin, and discuss its combination use, nano-formulations, safety, and current challenges towards development as an antibacterial agent. We hope that this review provides valuable insight, stimulates broader discussions, and spurs further developments around this promising natural product.
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