4.7 Article

Chronic Nicotine Exposure Increases Hematoma Expansion following Collagenase-Induced Intracerebral Hemorrhage in Rats

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BIOMOLECULES
卷 12, 期 5, 页码 -

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MDPI
DOI: 10.3390/biom12050621

关键词

cigarette; tobacco; smoking; risk factor; stroke

资金

  1. James and Esther King Biomedical Research Program [9JK08]

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This study evaluated the effect of chronic nicotine exposure on outcomes following spontaneous intracerebral hemorrhage (sICH). The results showed that nicotine treatment increased hematoma volume post-sICH and led to neurological deficits in both male and female rats. Understanding the mechanism of nicotine-dependent increase in hematoma growth is crucial for understanding the detrimental effect of tobacco use on the severity of bleeding following intracerebral hemorrhage.
Spontaneous intracerebral hemorrhage (sICH) is a deadly stroke subtype, and tobacco use increases sICH risk. However epidemiological studies show that, there are no confirmatory studies showing the effect of tobacco use on sICH outcome. Therefore, we evaluated the effect of chronic nicotine exposure (as a surrogate for tobacco use) on outcomes following sICH. Young male and female rats were randomly assigned to either nicotine (4.5 mg/kg b.w. per day) or vehicle (saline) treatment (2-3 weeks) groups. sICH was induced by injecting collagenase into the right striatum. Neurological score and hematoma volume were determined 24 h post-sICH. The hematoma volumes in nicotine-treated male and female rats were significantly higher by 42% and 48% when compared to vehicle-treated male and female rats, respectively. Neurological deficits measured in terms of neurological score for the nicotine-treated male and female groups were significantly higher when compared to the respective vehicle-treated male and female groups. Our results show that chronic nicotine exposure increases hematoma volume post-sICH in rats of both sexes. Identifying the mechanism of nicotine-dependent increase in hematoma growth post-sICH will be crucial to understanding the detrimental effect of tobacco use on the severity of bleeding following intracerebral hemorrhage.

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