4.7 Review

In Search of Differential Inhibitors of Aldose Reductase

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemistry & Molecular Biology

Development of coumarin-thiosemicarbazone hybrids as aldose reductase inhibitors: Biological assays, molecular docking, simulation studies and ADME evaluation

Aqeel Imran et al.

Summary: The study synthesized a series of potential aldose reductase inhibitors, among which compound 3n showed the highest potential, with high selectivity and affinity.

BIOORGANIC CHEMISTRY (2021)

Article Biochemistry & Molecular Biology

Which Properties Allow Ligands to Open and Bind to the Transient Binding Pocket of Human Aldose Reductase?

Anna Sandner et al.

Summary: The study demonstrates that the transient specificity pocket of aldose reductase has unique opening characteristics for specific ligands, and confirms that an electron-deficient aromatic group is an important prerequisite for occupying the pocket. Additionally, the binding position of the ligand in the pocket is not affected by a pH shift between 5 and 8.

BIOMOLECULES (2021)

Article Plant Sciences

Separation and Identification of Antioxidants and Aldose Reductase Inhibitors in Lepechinia meyenii (Walp.) Epling

Guanglei Zuo et al.

Summary: This study identified rosmarinic acid as the key compound in Lepechinia meyenii with antioxidant and AR inhibitory activities, providing scientific evidence for its traditional use as an anti-diabetic herbal medicine. The HSCCC separation method established in this study is effective for preparative separation of rosmarinic acid from natural products.

PLANTS-BASEL (2021)

Review Biochemistry & Molecular Biology

Development of Novel Indole-Based Bifunctional Aldose Reductase Inhibitors/Antioxidants as Promising Drugs for the Treatment of Diabetic Complications

Lucia Kovacikova et al.

Summary: This article discusses the potential role of aldose reductase inhibitors in treating diabetic complications and other diseases, reviews a series of compounds based on indoles with antioxidant properties and their biological activities, and discusses the structure-activity relationships involved.

MOLECULES (2021)

Article Biochemistry & Molecular Biology

Aldose Reductase Differential Inhibitors in Green Tea

Francesco Balestri et al.

BIOMOLECULES (2020)

Review Biochemistry & Molecular Biology

Natural Compounds as Source of Aldose Reductase (AR) Inhibitors for the Treatment of Diabetic Complications: A Mini Review

Ajmer Singh Grewal et al.

CURRENT DRUG METABOLISM (2020)

Review Biochemistry & Molecular Biology

Intra-site differential inhibition of multi-specific enzymes

Mario Cappiello et al.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2020)

Article Biochemistry & Molecular Biology

7 Soyasaponins from Zolfino bean as aldose reductase differential inhibitors

Francesco Balestri et al.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2019)

Article Biochemistry & Molecular Biology

Acid Derivatives of Pyrazolo[1,5-a]pyrimidine as Aldose Reductase Differential Inhibitors

Francesco Balestri et al.

CELL CHEMICAL BIOLOGY (2018)

Review Biochemistry & Molecular Biology

Regulatory roles of glutathione-S-transferases and 4-hydroxynonenal in stress-mediated signaling and toxicity

Yogesh C. Awasthi et al.

FREE RADICAL BIOLOGY AND MEDICINE (2017)

Review Biochemistry & Molecular Biology

4-Hydroxynonenal (HNE) modified proteins in metabolic diseases

Jose Pedro Castro et al.

FREE RADICAL BIOLOGY AND MEDICINE (2017)

Review Biochemistry & Molecular Biology

Contribution of the HNE-immunohistochemistry to modern pathological concepts of major human diseases

Kamelija Zarkovic et al.

FREE RADICAL BIOLOGY AND MEDICINE (2017)

Review Biochemistry & Molecular Biology

Enzymatic and non-enzymatic detoxification of 4-hydroxynonenal: Methodological aspects and biological consequences

Marco Mol et al.

FREE RADICAL BIOLOGY AND MEDICINE (2017)

Article Biochemistry & Molecular Biology

The use of dimethylsulfoxide as a solvent in enzyme inhibition studies: the case of aldose reductase

Livia Misuri et al.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2017)

Article Biochemistry & Molecular Biology

Edible vegetables as a source of aldose reductase differential inhibitors

Francesco Balestri et al.

CHEMICO-BIOLOGICAL INTERACTIONS (2017)

Review Chemistry, Medicinal

Updates on Aldose Reductase Inhibitors for Management of Diabetic Complications and Non-diabetic Diseases

Ajmer Singh Grewal et al.

MINI-REVIEWS IN MEDICINAL CHEMISTRY (2016)

Review Biochemistry & Molecular Biology

The role of glutathione reductase and related enzymes on cellular redox homoeostasis network

Narciso Couto et al.

FREE RADICAL BIOLOGY AND MEDICINE (2016)

Article Biochemistry & Molecular Biology

L-Idose: an attractive substrate alternative to D-glucose for measuring aldose reductase activity

Francesco Balestri et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2015)

Article Biochemistry & Molecular Biology

Modulation of aldose reductase activity by aldose hemiacetals

Francesco Balestri et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2015)

Article Biochemistry & Molecular Biology

The aldo-keto reductases (AKRs): Overview

Trevor M. Penning

CHEMICO-BIOLOGICAL INTERACTIONS (2015)

Review Biochemistry & Molecular Biology

4-Hydroxy-nonenal-A Bioactive Lipid Peroxidation Product

Rudolf J. Schaur et al.

BIOMOLECULES (2015)

Review Chemistry, Medicinal

Aldose Reductase Inhibitors of Plant Origin

Ciddi Veeresham et al.

PHYTOTHERAPY RESEARCH (2014)

Article Multidisciplinary Sciences

4-Hydroxy-2-nonenal Induces Apoptosis by Inhibiting AKT Signaling in Human Osteosarcoma Cells

Guang-rong Ji et al.

SCIENTIFIC WORLD JOURNAL (2014)

Article Endocrinology & Metabolism

Glutathionylated products of lipid peroxidation

Brigitte I Frohnert et al.

Adipocyte (2014)

Article Multidisciplinary Sciences

A New Approach to Control the Enigmatic Activity of Aldose Reductase

Antonella Del-Corso et al.

PLOS ONE (2013)

Article Mathematical & Computational Biology

Implication of Crystal Water Molecules in Inhibitor Binding at ALR2 Active Site

Hymavati et al.

COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE (2012)

Review Chemistry, Medicinal

Novel aldose reductase inhibitors: a patent survey (2006-present)

Maria Chatzopoulou et al.

EXPERT OPINION ON THERAPEUTIC PATENTS (2012)

Review Cardiac & Cardiovascular Systems

Activation of Protein Kinase C Isoforms and Its Impact on Diabetic Complications

Pedro Geraldes et al.

CIRCULATION RESEARCH (2010)

Review Medicine, General & Internal

Advanced glycation end-products and the kidney

Martin Busch et al.

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION (2010)

Article Biochemistry & Molecular Biology

Aldose reductase: A novel therapeutic target for inflammatory pathologies

Kota V. Ramana et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2010)

Article Biochemistry & Molecular Biology

From a Dull Enzyme to Something Else: Facts and Perspectives Regarding Aldose Reductase

A. Corso et al.

CURRENT MEDICINAL CHEMISTRY (2008)

Review Pharmacology & Pharmacy

THE ALDO-KETO REDUCTASE SUPERFAMILY AND ITS ROLE IN DRUG METABOLISM AND DETOXIFICATION

Oleg A. Barski et al.

DRUG METABOLISM REVIEWS (2008)

Article Biochemistry & Molecular Biology

Tracing changes in protonation: A prerequisite to factorize thermodynamic data of inhibitor binding to aldose reductase

Holger Steuber et al.

JOURNAL OF MOLECULAR BIOLOGY (2007)

Article Cardiac & Cardiovascular Systems

Contribution of polyol pathway to arteriolar dysfunction in hyperglycemia.: Role of oxidative stress, reduced NO, and enhanced PGH2/TXA2 mediation

Erika Toth et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2007)

Review Biochemistry & Molecular Biology

G protein regulation of MAPK networks

Z. G. Goldsmith et al.

ONCOGENE (2007)

Article Biochemistry & Molecular Biology

The structure of Apo R268A human aldose reductase: Hinges and latches that control the kinetic mechanism

KM Bohren et al.

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2005)

Article Biochemistry & Molecular Biology

Strategies for the design of inhibitors of aldose reductase, an enzyme showing pronounced induced-fit adaptations

G Klebe et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2004)

Article Biochemistry & Molecular Biology

Probing flexibility and induced-fit phenomena in aldose reductase by comparative crystal structure analysis and molecular dynamics simulations

CA Sotriffer et al.

PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2004)

Article Biochemistry & Molecular Biology

Ultrahigh resolution drug design I:: Details of interactions in human aldose reductase-inhibitor complex at 0.66 Å

EI Howard et al.

PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2004)

Article Biochemistry & Molecular Biology

Kinetic and structural characterization of the glutathione-binding site of aldose reductase

BL Dixit et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2000)