相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。
Review
Biochemistry & Molecular Biology
Carmen Llorens-Cebria et al.
Summary: The reduction-oxidation (redox) system involves the coordination of different electron gradients produced by enzymatic reactions. These reactions generate reactive oxygen species (ROS) and reactive nitrogen species (RNS), which play important roles in cell signaling pathways and cellular processes. However, excessive production of these oxidants can lead to oxidative stress (OS), which is pathological. OS is a major contributor to the onset of diabetic kidney disease (DKD). In DKD, glucose-induced toxicity promotes OS and mitochondrial dysfunction, impairing the function of proximal tubular cells in the kidney. Increased glucose levels and ROS enhance the activity of sodium/glucose co-transporter type 2 (SGLT2), further exacerbating OS. SGLT2 inhibitors have shown cardiovascular benefits in DKD, possibly by promoting a balanced equilibrium between oxidant and antioxidant mechanisms.
Review
Biochemistry & Molecular Biology
Marie Ito et al.
Summary: Mitochondrial dysfunction plays a significant role in the development and progression of diabetic kidney disease (DKD), involving oxidative phosphorylation, mitochondrial reactive oxygen species, biogenesis, fission and fusion, mitophagy, and urinary mitochondrial biomarkers. This review summarizes the glucose-induced and non-glucose-induced mitochondrial dysfunction, as well as the impact of different pathways on DKD.
Review
Biochemistry & Molecular Biology
Yu-Ting Zhu et al.
Summary: Podocytopathies are kidney diseases driven by podocyte injury. This review highlights the crucial role of mitochondrial oxidative stress in the pathogenesis of podocytopathies and its relationship with cell death in podocytes. Exogenous antioxidants can protect podocytes from damage. The review aims to identify new targets for improving the treatment of podocytopathies.
Review
Biochemistry & Molecular Biology
Liang-Jun Yan et al.
Summary: Cadmium, a nonessential metal heavily polluting the environment, can cause chronic damage to the kidneys, mainly accumulating in and damaging the proximal tubule of nephrons. Oxidative damage serves as a unifying mechanism for cadmium-induced renal toxicity, with antioxidants potentially ameliorating the injury.
Article
Biochemistry & Molecular Biology
Wojciech Knop et al.
Summary: Elevated levels of renalase in patients with CKD can serve as a risk factor for MACE, especially in HD patients. High renalase levels are associated with mortality in CKD patients.
Article
Biochemistry & Molecular Biology
Hristo Zlatev et al.
Summary: Controlled rewarming after extended cold preservation effectively improves mitochondrial recovery upon reperfusion and early functional outcome of kidney grafts.
Review
Biochemistry & Molecular Biology
Liang-Jun Yan
Summary: Diabetic kidney disease (DKD) is a common and severe complication of diabetes, mainly driven by NADH/NAD(+) redox imbalance and mitochondrial dysfunction. The review discusses strategies to counteract DKD, including the use of mitochondria-targeted antioxidants and caloric restriction.
Review
Biochemistry & Molecular Biology
Alexis Paulina Jimenez-Uribe et al.
Summary: Mitochondria play important roles in cell functions, especially in kidney function. Besides energy production, mitochondria also communicate with the rest of the cell through various pathways and participate in multiple metabolic processes, including the TCA cycle.
Review
Biochemistry & Molecular Biology
Ana Karina Aranda-Rivera et al.
Summary: Mitochondria play essential roles in cell physiology and kidney diseases by generating cellular energy and producing reactive oxygen species (ROS). However, overproduction of ROS in kidney diseases can lead to oxidative stress, disrupting mitochondrial function and altering cell signaling pathways, ultimately causing inflammation and cell apoptosis. Studies on the dysregulation of redox-sensitive signaling pathways in mitochondria could provide insights into potential therapeutic targets for kidney diseases.
Article
Biochemistry & Molecular Biology
Orawan Wongmekiat et al.
Summary: The study demonstrated that purple rice husk extract has a protective effect against diabetic kidney injury by improving mitochondrial function and reducing oxidative damage. This finding opens up possibilities for developing agricultural waste into useful products for diabetes health.
Article
Biochemistry & Molecular Biology
Torsten R. Goesch et al.
Summary: PrC-210 has shown potential to suppress kidney damage and inflammation caused by allograft kidney transplantation, reducing histologic damage, improving kidney function metrics, and decreasing levels of inflammatory cytokines and activated caspase.
Review
Biochemistry & Molecular Biology
Liang-Jun Yan
Summary: The kidneys are vulnerable to both acute kidney injury (AKI) and chronic kidney disease (CKD), with animal models being crucial for studying the pathological mechanisms of kidney disease. This article reviews a widely used animal model of kidney disease induced by folic acid (FA), discussing the major mechanisms of FA-induced kidney injury and its application in testing therapeutic approaches.
ANIMAL MODELS AND EXPERIMENTAL MEDICINE
(2021)
