4.7 Article

Progesterone Attenuates SIRT1-Deficiency-Mediated Pre-Eclampsia

期刊

BIOMOLECULES
卷 12, 期 3, 页码 -

出版社

MDPI
DOI: 10.3390/biom12030422

关键词

progesterone; pre-eclampsia; SIRT1; pre-eclampsia-like mice; SRT2104; metformin

资金

  1. National Natural Sciences Foundation of China [81971408, 81801469]
  2. National Key R&D Program of China [2016YFC1000403]
  3. 2020 Diligence. Excellence Clinical Innovative Team Project Study on the comprehensive management of pre-eclampsia and its pathogenesis by the Obstetrics and Gynecology Hospital of Fudan University [2021fckbc06]

向作者/读者索取更多资源

SIRT1 plays a significant role in the pathogenesis of pre-eclampsia, with progesterone showing better efficacy than metformin in alleviating symptoms mediated by SIRT1 deficiency.
Pre-eclampsia is a severe hypertensive disorder of pregnancy (HDP), mainly characterized by new-onset hypertension with proteinuria after 20-week gestation. Sirtuin1 (SIRT1), a class III histone deacetylase, is associated with the regulation of various pathophysiological processes, including inflammation, immune response, metabolism, and autophagy. However, the effect of SIRT1 in the pathogenesis of pre-eclampsia remains to be elucidated. In this study, we found that the expression of SIRT1 was relatively lower in the placentas and serum samples of pre-eclampsia patients. Typical pre-eclampsia-like symptoms, such as hypertension, proteinuria, fetal growth restriction, kidney injury, and a narrow placental labyrinth layer, were observed in SIRT1 knockdown (SIRT1(+/-)) mice. Of note, these performances could be improved after the intraperitoneal injection of SIRT1 agonist SRT2104. More importantly, we found that the efficacy of progesterone on attenuating symptoms of PE was profoundly better than that of metformin in SIRT1(+/-) mice. In addition, our results suggested that progesterone can promote the invasion and inhibit the apoptosis of trophoblasts. These data suggest that SIRT1 plays an important role in pre-eclampsia and that progesterone alleviates pre-eclampsia-like symptoms mediated by SIRT1 deficiency.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据