Cardiac Adverse Events after Vaccination-A Systematic Review

Letter Medicine, General & Internal

Myocardial Infarction, Stroke, and Pulmonary Embolism After BNT162b2 mRNA COVID-19 Vaccine in People Aged 75 Years or Older

Marie Joelle Jabagi et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2022)

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Letter Medicine, General & Internal

Reply to 'Letter to the editor: Myocarditis should be considered in those with a troponin rise and unobstructed coronary arteries following PfizerBioNTech COVID-19 vaccination'

E. Lee et al.

QJM-AN INTERNATIONAL JOURNAL OF MEDICINE (2022)

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Review Cardiac & Cardiovascular Systems

The impact of influenza vaccination in patients with cardiovascular disease: An overview of systematic reviews

Barbara S. Rodrigues et al.

Summary: This study conducted an overview of systematic reviews evaluating the effects of influenza vaccination in secondary prevention of cardiovascular disease. The results suggest that influenza vaccination is associated with a protective effect in patients with coronary artery disease and heart failure, reducing the risk of all-cause mortality and cardiovascular events.

TRENDS IN CARDIOVASCULAR MEDICINE (2021)

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Review Cardiac & Cardiovascular Systems

Myocarditis and inflammatory cardiomyopathy: current evidence and future directions

Carsten Tschoepe et al.

Summary: Inflammatory cardiomyopathy is a disease characterized by inflammatory cell infiltration into the myocardium and is predominantly mediated by viral infection. Despite extensive research, inflammatory cardiomyopathy complicated by left ventricular dysfunction, heart failure or arrhythmia is associated with a poor prognosis. The relative roles of the pathogen, host genomics and environmental factors in disease progression and healing are still under discussion.

NATURE REVIEWS CARDIOLOGY (2021)

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Article

Myocarditis following COVID-19 vaccination

Elisabeth Albert et al.

Radiology Case Reports (2021)

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Article Radiology, Nuclear Medicine & Medical Imaging

Acute myocarditis after a second dose of the mRNA COVID-19 vaccine: a report of two cases

Joseph Mansour et al.

Summary: We report two cases of myocarditis, occurring in two young and previously healthy individuals, temporally associated with the second dose of the mRNA-COVID-19 vaccine. Both patients presented with acute chest pain, changes on electrocardiogram (ECG), and elevated serum troponin levels within two days of receiving their second dose. Cardiac magnetic resonance (CMR) findings were consistent with acute myocarditis.

CLINICAL IMAGING (2021)

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Article Immunology

Myopericarditis after vaccination, Vaccine Adverse Event Reporting System (VAERS), 1990-2018

John R. Su et al.

Summary: A thorough analysis of myopericarditis reports to a national vaccine safety surveillance system in the United States revealed that most cases involved males with symptoms occurring within two weeks post-vaccination. Smallpox and anthrax vaccines were the most commonly reported vaccines associated with myopericarditis.

VACCINE (2021)

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Article Medicine, General & Internal

Myocarditis after Covid-19 Vaccination in a Large Health Care Organization

Guy Witberg et al.

Summary: Among 2.5 million patients who received the BNT162b2 mRNA vaccine in a large Israeli health care system, the incidence of myocarditis at 42 days was 2.13 cases per 100,000 persons, with the highest incidence (10.69 per 100,000 persons) among male patients between the ages of 16 and 29 years. Most cases of myocarditis were mild or moderate.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Editorial Material Medicine, General & Internal

Covid-19: European countries suspend use of Oxford-AstraZeneca vaccine after reports of blood clots

Jacqui Wise

BMJ-BRITISH MEDICAL JOURNAL (2021)

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Article Cardiac & Cardiovascular Systems

Heart Failure Association of the ESC, Heart Failure Society of America and Japanese Heart Failure Society Position statement on endomyocardial biopsy

Petar M. Seferovic et al.

Summary: Endomyocardial biopsy (EMB) is an invasive procedure commonly used for monitoring heart transplant rejection and diagnosing various cardiac disorders. Advances in EMB equipment and techniques have improved diagnostic precision. An expert consensus document provides a comprehensive overview on EMB, covering practical approaches, updated indications, revised surveillance plans, the impact of multimodality imaging, and current global clinical practices.

EUROPEAN JOURNAL OF HEART FAILURE (2021)

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Editorial Material Cardiac & Cardiovascular Systems

Acute Coronary Tree Thrombosis After Vaccination for COVID-19

Mateusz Tajstra et al.

JACC-CARDIOVASCULAR INTERVENTIONS (2021)

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Article Emergency Medicine

Type 1 Kounis Syndrome Induced by Inactivated SARS-COV-2 Vaccine

Ibrahim Halil Ozdemir et al.

Summary: This case report presents a rare occurrence of Kounis syndrome following inactivated coronavirus vaccine administration in a 41-year-old woman. The patient developed symptoms of flushing, palpitation, dyspnea, and chest pain after vaccination, with ECG changes and elevated Troponin-I levels. Coronary angiography showed no signs of coronary atherosclerosis. This case highlights the importance of monitoring and awareness of potential allergic reactions, such as Kounis syndrome, following COVID-19 vaccination.

JOURNAL OF EMERGENCY MEDICINE (2021)

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Article Immunology

Shedding the Light on Post-Vaccine Myocarditis and Pericarditis in COVID-19 and Non-COVID-19 Vaccine Recipients

Rima Hajjo et al.

Summary: Research shows that myocarditis and pericarditis are most commonly associated with COVID-19 vaccines, followed by non-COVID-19 vaccines; the frequency of cardiac adverse events is influenced by various factors; interferon-gamma plays a central role in the biological processes leading to cardiac adverse events.

VACCINES (2021)

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Review Immunology

Wuhan to World: The COVID-19 Pandemic

Ashok Kumar et al.

Summary: COVID-19 is a severe acute respiratory syndrome caused by SARS-CoV-2, a novel virus that has spread globally with higher infectivity and mortality compared to its earlier relatives. Understanding potential transmission routes and rapidly developed diagnostics are crucial in managing the disease.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2021)

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Article Immunology

Immune-Mediated Disease Flares or New-Onset Disease in 27 Subjects Following mRNA/DNA SARS-CoV-2 Vaccination

Abdulla Watad et al.

Summary: Although temporally-associated with SARS-CoV-2 vaccination, new-onset or flare of immune-mediated diseases (IMDs) appear rare. Most cases are of moderate severity and responsive to therapy, although some severe flares occurred.

VACCINES (2021)

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Article Emergency Medicine

Myocarditis after BNT162b2 vaccination in a healthy male

Kevin Watkins et al.

AMERICAN JOURNAL OF EMERGENCY MEDICINE (2021)

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Editorial Material Cardiac & Cardiovascular Systems

Myocarditis After SARS-CoV-2 Vaccination: A Vaccine-Induced Reaction?

Tommaso D'Angelo et al.

Summary: Vaccination is crucial in combating COVID-19, but can rarely lead to myocarditis. We present a case of a male patient who developed myopericarditis after receiving the vaccine.

CANADIAN JOURNAL OF CARDIOLOGY (2021)

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Article Cardiac & Cardiovascular Systems

Myocarditis With COVID-19 mRNA Vaccines

Biykem Bozkurt et al.

Summary: Myocarditis is a rare complication of COVID-19 mRNA vaccines, predominantly affecting young adult and adolescent males, with most patients showing improvement in symptoms. Possible mechanisms include molecular mimicry between viral proteins and self-antigens, dysregulated immune pathways, immune response to mRNA, and dysregulated cytokine expression.

CIRCULATION (2021)

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Letter Cardiac & Cardiovascular Systems

Myocarditis After BNT162b2 and mRNA-1273 Vaccination

Kathryn F. Larson et al.

CIRCULATION (2021)

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Letter Cardiac & Cardiovascular Systems

Myocarditis Temporally Associated With COVID-19 Vaccination

Carolyn M. Rosner et al.

CIRCULATION (2021)

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Editorial Material Medicine, General & Internal

A spectrum of cardiac manifestations post Pfizer-BioNTech COVID-19 vaccination

E. Lee et al.

QJM-AN INTERNATIONAL JOURNAL OF MEDICINE (2021)

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Editorial Material Immunology

The Novel Platform of mRNA COVID-19 Vaccines and Myocarditis: Clues into the Potential Mechanism

George Lazaros et al.

VACCINE (2021)

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Article Immunology

Myocarditis following COVID-19 mRNA vaccination

Saif Abu Mouch et al.

Summary: This study reported six cases of myocarditis occurring shortly after BNT162b2 vaccination, all in young males with mild clinical course. All patients responded to the vaccine, and myocarditis post-BNT162b2 vaccination may be considered an adverse reaction.

VACCINE (2021)

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Article Public, Environmental & Occupational Health

Use of COVID-19 Vaccines After Reports of Adverse Events Among Adult Recipients of Janssen (Johnson & Johnson) and mRNA COVID-19 Vaccines (Pfizer-BioNTech and Moderna): Update from the Advisory Committee on Immunization Practices — United States, July 2021

Hannah G. Rosenblum et al.

MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT (2021)

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Article Cardiac & Cardiovascular Systems

Myocarditis Following Immunization With mRNA COVID-19 Vaccines in Members of the US Military

Jay Montgomery et al.

Summary: This study investigated cases of myocarditis occurring in male patients within the US Military Health System after receiving mRNA COVID-19 vaccines between January and April 2021. A total of 23 male patients presented with acute chest pain within 4 days post-vaccination, with elevated troponin levels and findings consistent with myocarditis on imaging. The number of cases observed was higher than expected after a second dose of the vaccine among male military members.

JAMA CARDIOLOGY (2021)

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Article Cardiac & Cardiovascular Systems

Patients With Acute Myocarditis Following mRNA COVID-19 Vaccination

Han W. Kim et al.

Summary: This study described 7 patients with acute myocarditis, 4 of whom had received mRNA COVID-19 vaccination. All patients presented with severe chest pain, biomarker evidence of myocardial injury, and were hospitalized. Cardiac magnetic resonance imaging findings were typical for myocarditis. Further investigation is needed to determine associations of COVID-19 vaccination and myocarditis.

JAMA CARDIOLOGY (2021)

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Review Primary Health Care

Acute Myocardial Injury Following COVID-19 Vaccination: A Case Report and Review of Current Evidence from Vaccine Adverse Events Reporting System Database

Anasua Deb et al.

Summary: Adverse events related to COVID-19 vaccination, such as myocarditis, should be closely monitored by physicians. As COVID-19 vaccine administration expands, vigilance is needed for the possibility of new adverse events, especially cases with acute immune responses post-vaccination.

JOURNAL OF PRIMARY CARE AND COMMUNITY HEALTH (2021)

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Article Infectious Diseases

Acute myocarditis following administration of BNT162b2 vaccine

Mhd Baraa Habib et al.

Summary: The widespread use of vaccines has been associated with rare but serious complications in adults, leading to global concern. This case study highlights a young male patient who developed acute myocarditis three days after receiving the second dose of the BNT162b2 vaccine.

IDCASES (2021)

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Letter Endocrinology & Metabolism

Myocardial infarction after COVID-19 vaccination-casual or causal?

Subhankar Chatterjee et al.

DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS (2021)

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Review Anesthesiology

Viral Myocarditis-Incidence, Diagnosis and Management

Megan Olejniczak et al.

JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA (2020)

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Letter Immunology

Potential antigenic cross-reactivity between SARS-CoV-2 and human tissue with a possible link to an increase in autoimmune diseases

Aristo Vojdani et al.

CLINICAL IMMUNOLOGY (2020)

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Article Medicine, General & Internal

A Case Series of Smallpox Vaccination-Associated Myopericarditis: Effects on Safety and Readiness of the Active Duty Soldier

Simon A. Sarkisian et al.

MILITARY MEDICINE (2019)

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Article Critical Care Medicine

Acute fulminant myocarditis following influenza vaccination requiring extracorporeal membrane oxygenation

Youn-Jung Kim et al.

ACUTE AND CRITICAL CARE (2019)

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Review Pharmacology & Pharmacy

Recurrence of pericarditis after influenza vaccination: a case report and review of the literature

Riccardo Mei et al.

BMC PHARMACOLOGY & TOXICOLOGY (2018)

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Article Cardiac & Cardiovascular Systems

A case of biopsy-proven eosinophilic myocarditis related to tetanus toxoid immunization

Hiroyuki Yamamoto et al.

CARDIOVASCULAR PATHOLOGY (2018)

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Article Allergy

Post-vaccination myositis and myocarditis in a previously healthy male

Matthew P. Cheng et al.

ALLERGY ASTHMA AND CLINICAL IMMUNOLOGY (2016)

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Review Immunology

Safety monitoring in the Vaccine Adverse Event Reporting System (VAERS)

Tom T. Shimabukuro et al.

VACCINE (2015)

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Article Multidisciplinary Sciences

A Prospective Study of the Incidence of Myocarditis/Pericarditis and New Onset Cardiac Symptoms following Smallpox and Influenza Vaccination

Renata J. M. Engler et al.

PLOS ONE (2015)

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Letter Emergency Medicine

SMALLPOX VACCINATION-ASSOCIATED MYOPERICARDITIS IS MORE COMMON WITH THE NEWEST SMALLPOX VACCINE

David I. Bruner et al.

JOURNAL OF EMERGENCY MEDICINE (2014)

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Article Emergency Medicine

Takotsubo cardiomyopathy after anti-influenza vaccination: catecholaminergic effects of immune system

Kuljit Singh et al.

AMERICAN JOURNAL OF EMERGENCY MEDICINE (2013)

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Letter Cardiac & Cardiovascular Systems

Tako-Tsubo cardiomyopathy after influenza vaccination

Francesco Santoro et al.

INTERNATIONAL JOURNAL OF CARDIOLOGY (2013)

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Article Medicine, General & Internal

Myopericarditis and Pericarditis in the Deployed Military Member: A Retrospective Series

Andrew H. Lin et al.

MILITARY MEDICINE (2013)

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Article Emergency Medicine

CHEST PAIN, ST ELEVATION, AND POSITIVE CARDIAC ENZYMES IN AN AUSTERE ENVIRONMENT: DIFFERENTIATING SMALLPOX VACCINATION-MEDIATED MYOCARDITIS AND ACUTE CORONARY SYNDROME IN OPERATION IRAQI FREEDOM

Charles L. Taylor et al.

JOURNAL OF EMERGENCY MEDICINE (2012)

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Article Genetics & Heredity

Integrated analysis of genetic and proteomic data identifies biomarkers associated with adverse events following smallpox vaccination

D. M. Reif et al.

GENES AND IMMUNITY (2009)

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Article Immunology

Follow-up of cardiovascular adverse events after smallpox vaccination among civilians in the United States, 2003

Mercedes M. Sniadack et al.

CLINICAL INFECTIOUS DISEASES (2008)

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Article Cardiac & Cardiovascular Systems

Comparison of clinical presentation of acute myocarditis following smallpox vaccination to acute coronary syndromes in patients <40 years of age

RE Eckart et al.

AMERICAN JOURNAL OF CARDIOLOGY (2005)

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Article Clinical Neurology

Guillain-Barre syndrome coexisting with pericarditis or nephrotic syndrome after influenza vaccination

CD Kao et al.

CLINICAL NEUROLOGY AND NEUROSURGERY (2004)

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Review Cardiac & Cardiovascular Systems

Incidence and follow-up of inflammatory cardiac complications after smallpox vaccination

RE Eckart et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2004)

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Review Cardiac & Cardiovascular Systems

Smallpox vaccination and myopericarditis: A clinical review

DC Cassimatis et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2004)

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Article Medicine, General & Internal

Eosinophilic-lymphocytic myocarditis after smallpox vaccination

JG Murphy et al.

LANCET (2003)

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Article Immunology

Myocarditis after smallpox vaccination: A case report

G Saurina et al.

CLINICAL INFECTIOUS DISEASES (2003)

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Article Medicine, General & Internal

Myopericarditis following smallpox vaccination among vaccinia-naive US military personnel

JS Halsell et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2003)

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Letter Immunology

Cardiac dysrhythmia following smallpox vaccination

TJ Whitman et al.

CLINICAL INFECTIOUS DISEASES (2003)

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Article Critical Care Medicine

Acute myopericarditis after diphtheria, tetanus, and polio vaccination

F Boccara et al.

CHEST (2001)

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Article Critical Care Medicine

Symptomatic pericarditis after influenza vaccination - Report of two cases

A de Meester et al.

CHEST (2000)

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Cardiac Adverse Events after Vaccination-A Systematic Review

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