期刊
VACCINES
卷 10, 期 4, 页码 -出版社
MDPI
DOI: 10.3390/vaccines10040506
关键词
SARS-CoV-2; COVID-19; vaccination; antibodies; BNT162b2; mRNA-1273; ChAdOx1 nCoV-2019; Ad26.COV2
资金
- European Social Fund
The characteristics of changes in anti-SARS-CoV-2 IgG within one year of vaccination in healthcare workers were investigated. It was found that booster doses significantly increased the levels of IgG antibodies and could have a real impact on restricting the further transmission of the virus.
Background: The presented research made it possible to obtain the characteristics of changes in anti-SARS-CoV-2 IgG within one year of vaccination in healthcare workers. Materials and Methods: The research group consisted of 18,610 participants represented by medical and administration staff. IgG antibody concentrations were determined by ELISA. Results: At 5-8 months after full vaccination, the levels of anti-SARS-CoV-2 IgG with equal vaccines were similar. The exception was JNJ-78436735, for which IgG levels were significantly lower. In the 9th month after vaccination, an increase in the anti-SARS-CoV-2 IgG level, suggesting asymptomatic infection, was observed in a large group of participants. Significantly higher levels of anti-SARS-CoV-2 IgG antibodies were observed after the booster dose compared to the second dose. The increase in antibodies was observed already around the 5th day after the injection of the booster dose, and was maximized at approximately the 14th day. Conclusion: The cut-off date for protection against the disease seems to be the period 8-9 months from the vaccination for mRNA vaccines and 5-6 months for vector vaccines. The introduction of a booster dose was the right decision, which could have a real impact on restricting the further transmission of the virus.
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