期刊
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
卷 10, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fbioe.2022.873369
关键词
gene editing; tumor; nano-drug delivery vectors; gene therapy; gene-editing technique
资金
- National Key Research and Development Program of China [2017YFA0208100]
- NSFC [81871478, 32171379, 81941008, 81422026]
- Jilin Scientific and Technological Development Program [20190201094JC, 20200301007RQ]
- Interdisciplinary Innovation Project of the First Hospital of Jilin University [JDYYJCHX001]
- Fundamental Research Funds for the Central Universities, JLU
Malignant tumors are a serious threat to human health with limited effectiveness of traditional anti-tumor treatments. Therefore, gene therapy and gene editing techniques have become research focuses. Nano-drug delivery carriers can improve the efficiency of gene editing and hold promise in improving malignant tumor treatment.
Malignant tumors pose a serious threat to human health and have high fatality rates. Conventional clinical anti-tumor treatment is mainly based on traditional surgery, chemotherapy, radiotherapy, and interventional therapy, and even though these treatment methods are constantly updated, a satisfactory efficacy is yet to be obtained. Therefore, research on novel cancer treatments is being actively pursued. We review the classification of gene therapies of malignant tumors and their advantages, as well as the development of gene editing techniques. We further reveal the nano-drug delivery carrier effect in improving the efficiency of gene editing. Finally, we summarize the progress in recent years of gene editing techniques based on nano-drug delivery carriers in the treatment of various malignant tumors, and analyze the prospects of the technique and its restricting factors.
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