4.7 Article

In Vitro Study of Degradation and Cytocompatibility of Ceramics/PLA Composite Coating on Pure Zinc for Orthopedic Application

出版社

FRONTIERS MEDIA SA
DOI: 10.3389/fbioe.2022.856986

关键词

zinc; biodegradation behavior; cytocompatibility; PLA film; pH

资金

  1. National Natural Science Foundation of China [81272022]
  2. Innovation Foundation of Zengcheng, Guangzhou, China [185]

向作者/读者索取更多资源

A composite coating consisting of CaHPO4 conversion coating and polylactic acid (PLA) was constructed on pure zinc. The presence of the coating reduced the pH value and enhanced corrosion resistance, while also improving the cytocompatibility of pure zinc.
Zinc and its alloys are considered to be next-generation materials for fabricating absorbable biomedical devices. However, cytotoxicity has been reported to be associated with rapid degradation. To address these issues, a composite coating (PLA/Li-OCP) consisting of CaHPO4 conversion coating (Ca-P) and polylactic acid (PLA) decorated with Li-octacalcium phosphate particles was constructed on pure zinc. The immersion tests showed that the presence of Ca-P coating and PLA/Li-OCP coating on pure zinc could reduce the pH value. Compared with Ca-P coating, the introduction of the PLA/Li-OCP film on the Ca-P-coated samples could enhance the corrosion resistance, and there was one order of magnitude decrease in the corrosion current density. The cytocompatibility assay suggested that the PLA/Li-OCP coating favored the cell viability and upregulated the expression of related osteogenic-genes including RUNX2, OCN, and BMP. Therefore, the presence of the PLA/Li-OCP coating on pure zinc could effectively improve the degradation rate and cytocompatibility of pure zinc.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据