4.7 Review

The Role of m6A on Female Reproduction and Fertility: From Gonad Development to Ovarian Aging

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Rheumatology

METTL3-mediated m6A modification of ATG7 regulates autophagy-GATA4 axis to promote cellular senescence and osteoarthritis progression

Xiang Chen et al.

Summary: This study revealed the significant increase of senescent FLSs with OA progression, impacting autophagy and SASP expression. METTL3 negatively regulated autophagy-related genes, promoting FLS senescence. Inhibiting METTL3 could attenuate FLS senescence, offering a potential therapeutic strategy for OA.

ANNALS OF THE RHEUMATIC DISEASES (2022)

Article Obstetrics & Gynecology

N6-methyladenosine Demethylase FTO Induces the Dysfunctions of Ovarian Granulosa Cells by Upregulating Flotillin 2

Li Zhou et al.

Summary: The study revealed the mechanism of FTO in polycystic ovarian syndrome, showing that it promotes cell proliferation, reduces apoptosis, and induces insulin resistance in GCs by regulating FLOT2.

REPRODUCTIVE SCIENCES (2022)

Article Multidisciplinary Sciences

WTAP-mediated m6A modification of lncRNA NORAD promotes intervertebral disc degeneration

Gaocai Li et al.

Summary: Intervertebral disc degeneration (IVDD) is the main cause of low back pain, and Nucleus pulposus cell senescence plays an important role in its progression. The researchers found that the m6A modification of lncRNA NORAD, mediated by WTAP, is involved in IVDD. They also discovered that NORAD m6A modification is regulated by various factors, and its deficiency leads to increased cellular senescence.

NATURE COMMUNICATIONS (2022)

Article Oncology

m6A hypomethylation of DNMT3B regulated by ALKBH5 promotes intervertebral disc degeneration via E4F1 deficiency

Gaocai Li et al.

Summary: This study reveals the important role of N6-methyladenosine (m6A) in intervertebral disc degeneration (IVD) by modulating nucleus pulposus cell (NPC) senescence. The findings highlight the critical involvement of ALKBH5 and DNMT3B in NPC senescence and IVD degeneration, suggesting the therapeutic potential of targeting the m6A/DNMT3B/E4F1 axis for treating IVD degeneration.

CLINICAL AND TRANSLATIONAL MEDICINE (2022)

Article Biochemistry & Molecular Biology

Melatonin antagonizes ovarian aging via YTHDF2-MAPK-NF-κB pathway

Ruigong Zhu et al.

Summary: Cellular senescence is closely associated with age-related diseases, and ovarian aging serves as the pathophysiological foundation of reproductive system diseases. By investigating the protective role of melatonin in human ovarian surface epithelial cells, it was found that melatonin can antagonize oncogene-induced senescence by inhibiting the ROS-YTHDF2-MAPK-NF-kappa B pathway. These findings provide insights into potential strategies for preventing and treating ovarian aging.

GENES & DISEASES (2022)

Article Obstetrics & Gynecology

Decreased expression of m6A demethylase FTO in ovarian aging

Xiaoyan Sun et al.

Summary: This study revealed that the expression of FTO decreased while the content of m(6)A increased with aging in human follicular fluid, granulosa cells, and mouse ovary. Further investigation is required to understand the underlying mechanisms.

ARCHIVES OF GYNECOLOGY AND OBSTETRICS (2021)

Review Biochemistry & Molecular Biology

Multifaceted regulation of translation by the epitranscriptomic modification N6-methyadenosine

Xiao-Min Liu et al.

Summary: m(6)A, an emerging epitranscriptomic code, plays a crucial role in mediating translatomic stability by recruiting translation machinery proteins and serving as a physical barrier, thereby adding an additional layer of complexity to the regulation of translation.

CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY (2021)

Review Biochemistry & Molecular Biology

m6A RNA methylation: from mechanisms to therapeutic potential

P. Cody He et al.

Summary: m(6)A, the most prevalent mRNA modification, regulates gene expression by influencing mRNA metabolism in various physiological and pathophysiological processes. It plays a multifaceted role in mRNA decay, translation, and transcription, highlighting its crucial importance in post-transcriptional gene expression regulation.

EMBO JOURNAL (2021)

Review Oncology

The role of IGF2BP2, an m6A reader gene, in human metabolic diseases and cancers

Jinyan Wang et al.

Summary: IGF2BP2 is an RNA-binding protein that regulates cellular metabolism and cancer development by post-transcriptional regulation. It is also an independent prognostic factor for multiple cancer types.

CANCER CELL INTERNATIONAL (2021)

Article Public, Environmental & Occupational Health

Clinical Outcomes in High-Risk Pregnancies Due to Advanced Maternal Age

Rosaly Correa-de-Araujo et al.

Summary: Advanced maternal age (AMA) refers to women aged 35 and above, who are at increased risk of pregnancy complications that can negatively impact both maternal and perinatal outcomes. Close monitoring and management, understanding the relationship between age and preexisting conditions, and raising awareness about potential complications are crucial in the care of pregnant women of AMA.

JOURNAL OF WOMENS HEALTH (2021)

Article Cell Biology

METTL3-mediated mRNA N6-methyladenosine is required for oocyte and follicle development in mice

Haiyuan Mu et al.

Summary: m(6)A modification plays essential roles in follicle development and oocyte growth, regulating oocyte meiosis by enhancing RNA stability.

CELL DEATH & DISEASE (2021)

Review Biochemistry & Molecular Biology

Epigenetic regulations in mammalian spermatogenesis: RNA-m6A modification and beyond

Yiqian Gui et al.

Summary: The m(6)A modification plays a critical role in spermatogenesis, affecting different stages of male germ cell development. It is involved in RNA metabolism, impacted by environmental exposure, and capable of being inherited across generations.

CELLULAR AND MOLECULAR LIFE SCIENCES (2021)

Article Medicine, Research & Experimental

ALKBH5-mediated m6A mRNA methylation governs human embryonic stem cell cardiac commitment

Zhenbo Han et al.

Summary: This study reveals a previously unidentified role of m6A demethylase ALKBH5 in determining the cardiac lineage commitment of human embryonic stem cells, by regulating the components of H3K4 modifying enzyme complexes and enhancing the transcription of GATA4. Loss of function of ALKBH5 alters the expression of KDM5B and RBBP5 through impairing the stability of their mRNAs, which promotes the transcription of GATA4 by enhancing histone H3 Lys4 trimethylation at the promoter region.

MOLECULAR THERAPY-NUCLEIC ACIDS (2021)

Article Multidisciplinary Sciences

The cohesin stabilizer Sororin drives G2-M transition and spindle assembly in mammalian oocytes

Changyin Zhou et al.

Summary: Sororin functions as a regulator of meiotic G(2)-M transition and spindle assembly in mammalian oocytes, with its interactions with Cyclin B2 playing a crucial role in driving M phase entry and bipolar spindle formation in meiosis.

SCIENCE ADVANCES (2021)

Review Cell Biology

m6A Methylation Regulates Osteoblastic Differentiation and Bone Remodeling

Mei Huang et al.

Summary: Osteoporosis is a common bone disease in the elderly, characterized by decreased bone mass due to bone metabolism imbalance. The m6A modification, through epigenetic regulation, affects the biological processes of bone-related cells and related signaling pathways.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Review Developmental Biology

Epigenetic regulation of mRNA N-6-methyladenosine modifications in mammalian gametogenesis

Fang Fang et al.

Summary: N-6-methyladenosine (m(6)A) is a prevalent epigenetic modification in mRNA that influences various biological processes by regulating post-transcriptional gene expression in eukaryotes. Both m(6)A modification and related enzymes play roles in normal gametogenesis and embryonic development in many species. Loss of m(6)A can compromise fertility and early embryonic development.

MOLECULAR HUMAN REPRODUCTION (2021)

Article Cell Biology

m6A-independent genome-wide METTL3 and METTL14 redistribution drives the senescence-associated secretory phenotype

Pingyu Liu et al.

Summary: Research shows that METTL3 and METTL14 promote the senescence-associated secretory phenotype in an m(6)A-independent manner. METTL14 is redistributed to enhancers, while METTL3 is localized to pre-existing NF-kappa B sites in the promoters of SASP genes during senescence. Both are essential for SASP, but it is not regulated by m(6)A mRNA modification.

NATURE CELL BIOLOGY (2021)

Article Cell Biology

Novel circGFRα1 Promotes Self-Renewal of Female Germline Stem Cells Mediated by m6A Writer METTL14

Xiaoyong Li et al.

Summary: A highly expressed N-6-methyladenosine modified circRNA, circGFR alpha 1, was identified in mouse ovaries and specifically expressed during FGSC development. Knockdown of circGFR alpha 1 significantly reduced FGSC self-renewal, while its overexpression enhanced self-renewal. circGFR alpha 1 acts as a ceRNA, promoting FGSC self-renewal by sponging miR-449 and activating the GFR alpha 1 pathway.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Article Cell Biology

The m6A mRNA demethylase FTO in granulosa cells retards FOS-dependent ovarian aging

Zhong-xin Jiang et al.

Summary: The study demonstrates that m6A adenine regulates the function of GCs in female ovarian aging by modulating FTO demethylase, which in turn affects ovarian aging. FTO retards ovarian cell aging by regulating FOS expression.

CELL DEATH & DISEASE (2021)

Article Pharmacology & Pharmacy

Aging-Associated Differences in Epitranscriptomic m6A Regulation in Response to Acute Cardiac Ischemia/Reperfusion Injury in Female Mice

Xuan Su et al.

Summary: Elderly hearts show a different response to m6A RNA methylation compared to young hearts in acute myocardial ischemia/reperfusion injury, potentially due to differential expression levels of m6A RNA writers and erasers. Overexpression of Mettl3 in cardiomyocytes enhances m6A levels of Bax and PTEN under hypoxia/reperfusion stress, suggesting that Bax and PTEN are target genes of Mettl3 in response to ischemia/reperfusion injury.

FRONTIERS IN PHARMACOLOGY (2021)

Review Cell Biology

m6A Modification in Mammalian Nervous System Development, Functions, Disorders, and Injuries

Jun Yu et al.

Summary: In this review, recent progress on studies of m(6)A modification in the mammalian nervous system from neuronal development to basic and advanced brain functions are summarized. The detailed underlying mechanisms in each process mediated by m(6)A writers, erasers, and readers are highlighted. Additionally, the involvement of dysregulated m(6)A modification in neurological disorders and injuries is also discussed.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Review Biochemistry & Molecular Biology

Regulation of RNA N6-methyladenosine modification and its emerging roles in skeletal muscle development

Jiju Li et al.

Summary: N-6-methyladenosine (m(6)A) modification is a widely conserved chemical modification in cellular RNAs that plays a critical role in skeletal muscle development. Exploration of the functions and mechanisms of m(6)A modification and its regulators provides a deeper understanding of the regulatory mechanisms underlying skeletal muscle development.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2021)

Article Biotechnology & Applied Microbiology

N6-methyladenosine dynamics in neurodevelopment and aging, and its potential role in Alzheimer's disease

Andrew M. Shafik et al.

Summary: The study reveals that m(6)A modification exhibits temporal and spatial dynamics in neurodevelopment and aging, with tissue-specific methylation associated with mRNA expression and tissue-specific processes. Aging leads to an increase in m(6)A sites, with a negative effect on mRNA expression, and Alzheimer's disease-related genes show decreased m(6)A methylation correlated with reduced protein levels.

GENOME BIOLOGY (2021)

Letter Oncology

Characterization of m6A in mouse ovary and testis

Xiaofeng Sun et al.

CLINICAL AND TRANSLATIONAL MEDICINE (2020)

Article Biochemistry & Molecular Biology

METTL3 counteracts premature aging via m6A-dependent stabilization of MIS12 mRNA

Zeming Wu et al.

NUCLEIC ACIDS RESEARCH (2020)

Article Cell Biology

YTHDF2 Regulates Maternal Transcriptome Degradation and Embryo Development in Goat

Mingtian Deng et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

Article Environmental Sciences

Constant light exposure causes oocyte meiotic defects and quality deterioration in mice

Huiting Zhang et al.

ENVIRONMENTAL POLLUTION (2020)

Review Obstetrics & Gynecology

Demographic and evolutionary trends in ovarian function and aging

Triin Laisk et al.

HUMAN REPRODUCTION UPDATE (2019)

Article Chemistry, Multidisciplinary

RNA-Binding Protein IGF2BP2/IMP2 is a Critical Maternal Activator in Early Zygotic Genome Activation

Hong-Bin Liu et al.

ADVANCED SCIENCE (2019)

Article Agriculture, Dairy & Animal Science

Profiling of RNA N6-methyladenosine methylation during follicle selection in chicken ovary

Yu Fan et al.

POULTRY SCIENCE (2019)

Review Oncology

The interplay between m6A RNA methylation and noncoding RNA in cancer

Shuai Ma et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2019)

Article Chemistry, Multidisciplinary

Proteasome-Independent Protein Knockdown by Small-Molecule Inhibitor for the Undruggable Lung Adenocarcinoma

Wei Zhou et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2019)

Review Cell Biology

Can ovarian aging be delayed by pharmacological strategies?

Jinjin Zhang et al.

AGING-US (2019)

Review Obstetrics & Gynecology

Regulation of chromosome segregation in oocytes and the cellular basis for female meiotic errors

Jessica Greaney et al.

HUMAN REPRODUCTION UPDATE (2018)

Article Biochemistry & Molecular Biology

R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m6A/MYC/CEBPA Signaling

Rui Su et al.

Article Endocrinology & Metabolism

Epigallocatechin gallate targets FTO and inhibits adipogenesis in an mRNA m6A-YTHDF2-dependent manner

Ruifan Wu et al.

INTERNATIONAL JOURNAL OF OBESITY (2018)

Article Cell Biology

Increased N6-methyladenosine causes infertility is associated with FTO expression

Chenyue Ding et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2018)

Review Cell Biology

Reading m6A in the Transcriptome: m6A-Binding Proteins

Deepak P. Patil et al.

TRENDS IN CELL BIOLOGY (2018)

Article Biotechnology & Applied Microbiology

Ythdf2-mediated m6A mRNA clearance modulates neural development in mice

Miaomiao Li et al.

GENOME BIOLOGY (2018)

Article Chemistry, Multidisciplinary

RNA Chemical Proteomics Reveals the N6-Methyladenosine (m6A)-Regulated Protein-RNA Interactome

A. Emilia Arguello et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2017)

Article Multidisciplinary Sciences

m6A-dependent maternal mRNA clearance facilitates zebrafish maternal-to-zygotic transition

Boxuan Simen Zhao et al.

NATURE (2017)

Article Multidisciplinary Sciences

m6A modulates haematopoietic stem and progenitor cell specification

Chunxia Zhang et al.

NATURE (2017)

Review Genetics & Heredity

The interplay of epigenetic marks during stem cell differentiation and development

Yaser Atlasi et al.

NATURE REVIEWS GENETICS (2017)

Article Multidisciplinary Sciences

The m6A pathway facilitates sex determination in Drosophila

Lijuan Kan et al.

NATURE COMMUNICATIONS (2017)

Article Biochemistry & Molecular Biology

Nuclear m6A Reader YTHDC1 Regulates mRNA Splicing

Wen Xiao et al.

MOLECULAR CELL (2016)

Article Biochemistry & Molecular Biology

N6-methyladenosine Modulates Messenger RNA Translation Efficiency

Xiao Wang et al.

Article Cell & Tissue Engineering

m6A RNA Methylation Is Regulated by MicroRNAs and Promotes Reprogramming to Pluripotency

Tong Chen et al.

CELL STEM CELL (2015)

Article Biochemistry & Molecular Biology

Meclofenamic acid selectively inhibits FTO demethylation of m(6)A over ALKBH5

Yue Huang et al.

NUCLEIC ACIDS RESEARCH (2015)

Article Biochemistry & Molecular Biology

Synthesis of a FTO Inhibitor with Anticonvulsant Activity

Guanqun Zheng et al.

ACS CHEMICAL NEUROSCIENCE (2014)

Article Multidisciplinary Sciences

N6-methyladenosine-dependent regulation of messenger RNA stability

Xiao Wang et al.

NATURE (2014)

Article Biochemistry & Molecular Biology

A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation

Jianzhao Liu et al.

NATURE CHEMICAL BIOLOGY (2014)

Article Biochemistry & Molecular Biology

Structural basis for selective binding of m6A RNA by the YTHDC1 YTH domain

Chao Xu et al.

NATURE CHEMICAL BIOLOGY (2014)

Review Genetics & Heredity

Gene expression regulation mediated through reversible m6A RNA methylation

Ye Fu et al.

NATURE REVIEWS GENETICS (2014)

Review Cell Biology

The dynamic epitranscriptome: N6-methyladenosine and gene expression control

Kate D. Meyer et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2014)

Article Biochemistry & Molecular Biology

ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility

Guanqun Zheng et al.

MOLECULAR CELL (2013)

Article Chemistry, Multidisciplinary

Development of Cell-Active N6-Methyladenosine RNA Demethylase FTO Inhibitor

Baoen Chen et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2012)

Article Multidisciplinary Sciences

Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq

Dan Dominissini et al.

NATURE (2012)

Article Biochemistry & Molecular Biology

N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO

Guifang Jia et al.

NATURE CHEMICAL BIOLOGY (2011)

Review Obstetrics & Gynecology

Meiosis errors in over 20,000 oocytes studied in the practice of preimplantation aneuploidy testing

Anver Kuliev et al.

REPRODUCTIVE BIOMEDICINE ONLINE (2011)

Review Genetics & Heredity

To ERR (meiotically) is human: The genesis of human aneuploidy

T Hassold et al.

NATURE REVIEWS GENETICS (2001)