期刊
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
卷 10, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fcell.2022.901652
关键词
organoids model; brain; pluripotenct stem cells; electrical stimulation; CNS; bioelectricity; retina
资金
- Luminesce Alliance-Innovation for Children's Health [PPM1 K5116/RD274]
- NSW Government
- CSIC from Spanish National Research Council (CSIC) [LINKA20342]
- Australian Government
This article discusses recent findings in the field of bioelectricity related to the central nervous system, explores the possible mechanisms of bioelectric regulation of CNS development and function, and explores the potential of utilizing electrical stimulation as a novel technique for engineering next-generation organoid models.
Pluripotent stem cell-derived organoid models of the central nervous system represent one of the most exciting areas in in vitro tissue engineering. Classically, organoids of the brain, retina and spinal cord have been generated via recapitulation of in vivo developmental cues, including biochemical and biomechanical. However, a lesser studied cue, bioelectricity, has been shown to regulate central nervous system development and function. In particular, electrical stimulation of neural cells has generated some important phenotypes relating to development and differentiation. Emerging techniques in bioengineering and biomaterials utilise electrical stimulation using conductive polymers. However, state-of-the-art pluripotent stem cell technology has not yet merged with this exciting area of bioelectricity. Here, we discuss recent findings in the field of bioelectricity relating to the central nervous system, possible mechanisms, and how electrical stimulation may be utilised as a novel technique to engineer next-generation organoids.
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