期刊
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
卷 10, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fcell.2022.913458
关键词
chromatin; interaction; LAD; lamina-associated domain; nuclear envelope; polymer modeling; restraint
资金
- University of Oslo
- Research Council of Norway
- Norwegian Cancer Society
- South-East Health Norway
This article provides an overview of the characteristics and methods of chromatin-lamina interactions, as well as the research progress and biological insights inferred from modeling chromatin-lamina interactions in normal and disease states. Future directions for development are also discussed.
Associations of chromatin with the nuclear lamina, at the nuclear periphery, help shape the genome in 3 dimensions. The genomic landscape of lamina-associated domains (LADs) is well characterized, but much remains unknown on the physical and mechanistic properties of chromatin conformation at the nuclear lamina. Computational models of chromatin folding at, and interactions with, a surface representing the nuclear lamina are emerging in attempts to characterize these properties and predict chromatin behavior at the lamina in health and disease. Here, we highlight the heterogeneous nature of the nuclear lamina and LADs, outline the main 3-dimensional chromatin structural modeling methods, review applications of modeling chromatin-lamina interactions and discuss biological insights inferred from these models in normal and disease states. Lastly, we address perspectives on future developments in modeling chromatin interactions with the nuclear lamina.
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