4.7 Review

miR-874: An Important Regulator in Human Diseases

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Article Oncology

Long noncoding RNA DANCR confers cytarabine resistance in acute myeloid leukemia by activating autophagy via the miR-874-3P/ATG16L1 axis

Hao Zhang et al.

Summary: This study identifies DANCR as a positive regulator of Ara-C resistance in human AML cells, suggesting that this lncRNA may serve as a potential target for overcoming Ara-C resistance in AML chemotherapy by promoting MIR-874-3P/ATG16L1 axis-regulated autophagy.

MOLECULAR ONCOLOGY (2021)

Article Oncology

LncRNA MCF2L-AS1 aggravates proliferation, invasion and glycolysis of colorectal cancer cells via the crosstalk with miR-874-3p/FOXM1 signaling axis

Zhandong Zhang et al.

Summary: The study revealed that MCF2L-AS1 plays a crucial role in CRC by modulating the miR-874-3p/FOXM1 axis to promote tumorigenesis and glycolysis progression.

CARCINOGENESIS (2021)

Article Biotechnology & Applied Microbiology

Inhibition of lncRNA DCST1-AS1 suppresses proliferation, migration and invasion of cervical cancer cells by increasing miR-874-3p expression

Junli Liu et al.

Summary: DCST1-AS1 is highly expressed in cervical cancer tissues and cells, and its inhibition can suppress the proliferation, invasion, and migration of cervical cancer cells by increasing miR-874-3p expression.

JOURNAL OF GENE MEDICINE (2021)

Article Biotechnology & Applied Microbiology

Long non-coding RNA MCF2L-AS1 promotes the aggressiveness of colorectal cancer by sponging miR-874-3p and thereby up-regulating CCNE1

Fa-Kun Huang et al.

Summary: Our study identified a novel CRC-related lncRNA, MCF2L-AS1, which is highly expressed in CRC and may serve as a potential diagnostic and prognostic biomarker for CRC patients. The newly identified MCF2L-AS1/miR-874-3p/CCNE1 axis plays a role in modulating the initiation and progression of CRC by promoting proliferation, migration, invasion, and inhibiting apoptosis in CRC cells.

JOURNAL OF GENE MEDICINE (2021)

Article Neurosciences

MiR-874 Inhibits Cell Proliferation, Migration, and Invasion of Glioma Cells and Correlates with Prognosis of Glioma Patients

Yongjuan Li et al.

Summary: Previous studies have shown abnormal expression of miR-874 in various tumors, but its role in glioma was unknown. This study found that miR-874 was significantly downregulated in glioma tissues and cell lines, and its decreased expression was associated with tumor size, KPS, and WHO grade. Functional assays revealed that upregulation of miR-874 inhibited proliferation, migration, and invasion of glioma cells in vitro, suggesting its potential as a prognostic biomarker and therapeutic target for glioma.

NEUROMOLECULAR MEDICINE (2021)

Article Cell Biology

Ectopic expression of microRNA-874 represses epithelial mesenchymal transition through the NF-κB pathway via CCNE1 in cholangiocarcinoma

Xin Pan et al.

Summary: This study found that miR-874 negatively regulates CCNE1 in CC, inhibiting the NF-κB pathway and suppressing EMT. Overexpression of miR-874 may have favorable outcomes for the treatment of CC.

CELLULAR SIGNALLING (2021)

Article Neurosciences

Long non-coding RNA MIAT impairs neurological function in ischemic stroke via up-regulating microRNA-874-3p-targeted IL1B

Shuai Zhang et al.

Summary: This study demonstrates that MIAT upregulates miR-874-3p and targets IL1B in IS, leading to impaired neurological function. Inhibiting MIAT or IL1B, or increasing miR-874-3p levels, can improve behavioral activities and neurological function in mice, reduce brain damage, and inflammation.

BRAIN RESEARCH BULLETIN (2021)

Article Pharmacology & Pharmacy

MiR-874-3p plays a protective role in intervertebral disc degeneration by suppressing MMP2 and MMP3

Qingxin Song et al.

Summary: The study found that the expression level of miR-874-3p was significantly decreased in IDD patients, and it could target and repress MMP2 and MMP3 expression, potentially providing a diagnostic marker and treatment candidate for IDD, as well as direction for future investigations on cancer and inflammation.

EUROPEAN JOURNAL OF PHARMACOLOGY (2021)

Article Cell Biology

Circular RNA circANAPC2 mediates the impairment of endochondral ossification by miR-874-3p/SMAD3 signalling pathway in idiopathic short stature

Xijuan Liu et al.

Summary: The study reveals that circANAPC2 plays a role in ISS by affecting the proliferation and cell cycle of chondrocytes through regulation of miR-874-3p and Smad3 expression, leading to suppression of chondrocyte growth and ossification processes.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)

Article Biotechnology & Applied Microbiology

Inhibition of hsa_circ_0003489 shifts balance from autophagy to apoptosis and sensitizes multiple myeloma cells to bortezomib via miR-874-3p/HDAC1 axis

Fa-Qing Tian et al.

Summary: Silencing hsa_circ_0003489 significantly inhibits MM cell viability, proliferation, and autophagy while promoting apoptosis. It enhances the cytotoxic effects of BTZ in MM cells and reverses its promotion of autophagy.

JOURNAL OF GENE MEDICINE (2021)

Article Oncology

The direct miR-874-3p-target FAM84A promotes tumor development in papillary thyroid cancer

Yu Ding et al.

Summary: With the advancement in diagnostic technology, the importance of exploring molecular targets for improving the treatment and prognosis of papillary thyroid carcinoma (PTC) is evident. Studies have shown the involvement of FAM84A in the development of various tumors, making it a potential diagnostic and therapeutic target for PTC.

MOLECULAR ONCOLOGY (2021)

Article Medicine, Research & Experimental

MicroRNA-874-3p promotes testosterone-induced granulosa cell apoptosis by suppressing HDAC1-mediated p53 deacetylation

Youhua Wei et al.

Summary: MiR-874-3p is upregulated in PCOS and promotes testosterone-induced GC apoptosis by suppressing HDAC1-mediated p53 deacetylation, indicating a potential pathogenic mechanism in PCOS and GC apoptosis.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2021)

Article Medicine, General & Internal

Circ_0007142 downregulates miR-874-3p-mediated GDPD5 on colorectal cancer cells

Yueqing Wang et al.

Summary: The study revealed that Circ_0007142 regulates the growth, apoptosis, and ferroptosis of CRC cells by modulating miR-874-3p and GDPD5. This suggests that Circ_0007142 may serve as a valuable marker for ferroptosis in CRC therapy.

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION (2021)

Article Dentistry, Oral Surgery & Medicine

MiR-874-3p inhibits osteogenic differentiation of human periodontal ligament fibroblasts through regulating Wnt/β-catenin pathway

Shengzhang Song et al.

Summary: This study revealed that miR-874-3p inhibits osteogenic differentiation of hPDLF by regulating the Wnt/β-catenin pathway.

JOURNAL OF DENTAL SCIENCES (2021)

Article Biochemistry & Molecular Biology

Overexpression of miR-874-3p alleviates LPS-induced apoptosis and inflammation in alveolar epithelial cell by targeting EGR3/NF-κB

Huirun Yang et al.

Summary: The study evaluated the role of miR-874-3p in pediatric pneumonia, showing that it negatively regulates EGR3 expression to promote cell viability, inhibit apoptosis, and inflammation in LPS-treated cells. The findings suggest that miR-874-3p could potentially serve as a therapeutic target for pneumonia by suppressing the NF-kappa B pathway.

ACTA BIOCHIMICA POLONICA (2021)

Article Genetics & Heredity

Circ_0040039 May Aggravate Intervertebral Disk Degeneration by Regulating the MiR-874-3p-ESR1 Pathway

Yongjin Li et al.

Summary: This study identified functional molecules related to intervertebral disk degeneration (IDD) using bioinformatics tools, and revealed that circular RNA circ_0040039 may aggravate IDD by regulating miR-874-3p and ESR1 expression in nucleus pulposus cells (NPCs). The signaling pathway discovered in this study could potentially provide novel therapeutic strategies and targets for the diagnosis and treatment of IDD-related diseases.

FRONTIERS IN GENETICS (2021)

Article Cell Biology

Analysis of microRNA regulating cell cycle-related tumor suppressor genes in endometrial cancer patients

Lukasz Witek et al.

Summary: Endometrial cancer, the most common malignancy of the female genital system in developed countries, is affected by the differential expression of five miRNAs that regulate tumor suppressor genes related to the cell cycle. Among these miRNAs, mir-874-3p shows promise for playing a key role in endometrial adenocarcinoma proliferation.

HUMAN CELL (2021)

Article Biochemistry & Molecular Biology

Up-regulated lnc-lung cancer associated transcript 1 enhances cell migration and invasion in breast cancer progression

Ya-Lun Li et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2020)

Article Biotechnology & Applied Microbiology

miR-874-3p inhibits cell migration through targeting RGS4 in osteosarcoma

Wei-Gang Liu et al.

JOURNAL OF GENE MEDICINE (2020)

Article Biotechnology & Applied Microbiology

Circ_0005576 Promotes Malignant Progression Through miR-874/CDK8 Axis in Colorectal Cancer

Chen Yu et al.

ONCOTARGETS AND THERAPY (2020)

Article Cell Biology

Tanshinone I inhibits the growth and metastasis of osteosarcoma via suppressing JAK/STAT3 signalling pathway

Weiguo Wang et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2019)

Article Medicine, Research & Experimental

Upregulation of miR-874-3p decreases cerebral ischemia/reperfusion injury by directly targeting BMF and BCL2L13

Dongxiao Jiang et al.

BIOMEDICINE & PHARMACOTHERAPY (2019)

Article Medicine, Research & Experimental

LncRNA H19 functions as an Aquaporin 1 competitive endogenous RNA to regulate microRNA-874 expression in LPS sepsis

Yu Fang et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

Article Allergy

MicroRNA

Thomas X. Lu et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2018)

Article Biochemistry & Molecular Biology

Upregulation of miR-874-3p and miR-874-5p inhibits epithelial ovarian cancer malignancy via SIK2

Bairong Xia et al.

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY (2018)

Article Biochemistry & Molecular Biology

MicroRNA-874 targeting SUFU involves in osteoblast proliferation and differentiation in osteoporosis rats through the Hedgehog signaling pathway

Jian-Chun Lin et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2018)

Article Oncology

miR-874 regulates multiple-drug resistance in gastric cancer by targeting ATG16L1

Haijin Huang et al.

INTERNATIONAL JOURNAL OF ONCOLOGY (2018)

Article Biochemistry & Molecular Biology

MicroRNA-874-mediated inhibition of the major G1/S phase cyclin, CCNE1, is lost in osteosarcomas

Tanushree Ghosh et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2017)

Article Medicine, Research & Experimental

Elevated levels of granzyme B correlated with miR-874-3p downregulation in patients with acute myocardial infarction

Youyou Yan et al.

BIOMARKERS IN MEDICINE (2017)

Review Oncology

Targeting autophagy in cancer

Jean M. Mulcahy Levy et al.

NATURE REVIEWS CANCER (2017)

Correction Medicine, Research & Experimental

MicroRNA dysregulation in cancer: diagnostics, monitoring and therapeutics. A comprehensive review (vol 4, pg 143, 2012)

Marilena V. Iorio et al.

EMBO MOLECULAR MEDICINE (2017)

Article Biochemistry & Molecular Biology

MicroRNA 874-3p Exerts Skeletal Anabolic Effects Epigenetically during Weaning by Suppressing Hdac1 Expression

Priyanka Kushwaha et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2016)

Article Gastroenterology & Hepatology

miR-874 Inhibits cell proliferation, migration and invasion through targeting aquaporin-3 in gastric cancer

Baofei Jiang et al.

JOURNAL OF GASTROENTEROLOGY (2014)

Article Biochemistry & Molecular Biology

Suppression of tumor cell invasiveness and in vivo tumor growth by microRNA-874 in non-small cell lung cancer

Divya Kesanakurti et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2013)

Review Genetics & Heredity

Adult-specific functions of animal microRNAs

Kailiang Sun et al.

NATURE REVIEWS GENETICS (2013)

Article Cell Biology

miR-874 regulates myocardial necrosis by targeting caspase-8

K. Wang et al.

CELL DEATH & DISEASE (2013)

Review Pharmacology & Pharmacy

Targeting the Wnt/ββ-catenin signaling pathway in human cancers

Hisayuki Yao et al.

EXPERT OPINION ON THERAPEUTIC TARGETS (2011)

Review Oncology

HDAC family: What are the cancer relevant targets?

Olaf Witt et al.

CANCER LETTERS (2009)