Novel Insights in the Regulatory Mechanisms of Ferroptosis in Hepatocellular Carcinoma

Ferroptosis is a newly defined programmed cell death, which by its mechanism differs from other programmed cell death processes such as apoptosis, necrosis, and autophagy. It has a unique morphology and biological properties that antioxidants and iron-chelating agents can regulate. Ferroptosis has the characteristics of iron ion deposition and dependence on lipid peroxidation. It can affect the progression of many cancers, including liver cancer, by inducing an intracellular iron-dependent accumulation of reactive oxygen species, providing new possibilities for cancer treatment. At present, great progress has been made in exploring the molecular mechanism of ferroptosis. In this review, we summarize the characteristics, mechanisms, and regulatory factors of ferroptosis in detail, discuss the progress of ferroptosis research in liver cancer, and provide directions and new ideas for the treatment of hepatocellular carcinoma.

Automated summary

Ferroptosis is a newly defined programmed cell death process that differs from other types of programmed cell death. It can be regulated by antioxidants and iron-chelating agents, and it affects cancer progression by influencing iron ion deposition and lipid peroxidation. Significant progress has been made in understanding the molecular mechanism of ferroptosis.