期刊
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
卷 10, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fcell.2022.882211
关键词
inflammaging; cardiovascular disease; aging; inflammation; senescence
资金
- Swiss National Science Foundation [310030_197510]
- Swiss Heart Foundation
- Alfred and Annemarie von Sick Grants for Translational and Clinical Research Cardiology and Oncology
- Foundation for Cardiovascular Research- Zurich Heart House
- Sheikh Khalifa's Foundation Ass. Professorship at the Faculty of Medicine. University of Zurich
- Swiss National Science Foundation (SNF) [310030_197510] Funding Source: Swiss National Science Foundation (SNF)
The improvements in healthcare services and quality of life are leading to a longer life expectancy, resulting in a larger population of elderly individuals who are more susceptible to age-related cardiovascular diseases. Inflammation has been recognized as a key factor in the pathogenesis of cardiovascular diseases, suggesting that inflamm-aging could potentially be a driver of age-related cardiovascular afflictions and a viable therapeutic target.
The improvements in healthcare services and quality of life result in a longer life expectancy and a higher number of aged individuals, who are inevitably affected by age-associated cardiovascular (CV) diseases. This challenging demographic shift calls for a greater effort to unravel the molecular mechanisms underlying age-related CV diseases to identify new therapeutic targets to cope with the ongoing aging pandemic. Essential for protection against external pathogens and intrinsic degenerative processes, the inflammatory response becomes dysregulated with aging, leading to a persistent state of low-grade inflammation known as inflamm-aging. Of interest, inflammation has been recently recognized as a key factor in the pathogenesis of CV diseases, suggesting inflamm-aging as a possible driver of age-related CV afflictions and a plausible therapeutic target in this context. This review discusses the molecular pathways underlying inflamm-aging and their involvement in CV disease. Moreover, the potential of several anti-inflammatory approaches in this context is also reviewed.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据