☆ 4.7 Review

Extracellular Vesicles: The Landscape in the Progression, Diagnosis, and Treatment of Triple-Negative Breast Cancer

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2022)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Review Oncology

Treatment landscape of triple-negative breast cancer - expanded options, evolving needs

Giampaolo Bianchini et al.

Summary: Recent advances in omics technologies have improved our understanding of the heterogeneity and microenvironment of triple-negative breast cancers (TNBCs), supporting a view of this breast cancer subtype as an ecosystem that encompasses both intrinsic and extrinsic features of cancer cells. The authors of this Review describe the current and upcoming therapeutic landscape of TNBC and discuss how an integrated view of the TNBC ecosystem can provide improved opportunities for tailoring treatment.

NATURE REVIEWS CLINICAL ONCOLOGY (2022)

添加到收藏夹

Article Oncology

The potential role of cofilin-1 in promoting triple negative breast cancer (TNBC) metastasis via the extracellular vesicles (EVs)

Jane Howard et al.

Summary: Triple negative breast cancer (TNBC) is an aggressive cancer associated with poor survival outcomes, with increased levels of cofilin-1 protein linked to poor prognosis in patients. Additionally, cofilin-1 may play a key role in promoting tumor cell migration.

TRANSLATIONAL ONCOLOGY (2022)

添加到收藏夹

Article Cell Biology

Molecular subtyping and genomic profiling expand precision medicine in refractory metastatic triple-negative breast cancer: the FUTURE trial

Yi-Zhou Jiang et al.

Summary: The FUTURE trial demonstrated the clinical benefit of subtyping-based targeted therapy for refractory metastatic TNBC, with immunotherapy showing the highest objective response rate among the treatment arms. Somatic mutations of TOP2A and CD8 immunohistochemical score may have the potential to predict immunotherapy response in the immunomodulatory subtype of TNBC.

CELL RESEARCH (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Exosomes as mediators of immune regulation and immunotherapy in cancer

Fernanda G. Kugeratski et al.

Summary: Exosomes play crucial roles in cancer by either promoting tumor development or inhibiting tumor immune suppression. They deliver signals that affect immune regulation of lymphoid and myeloid cell populations in tumors.

FEBS JOURNAL (2021)

添加到收藏夹

Article Immunology

PD-1 restraint of regulatory T cell suppressive activity is critical for immune tolerance

Catherine L. Tan et al.

Summary: Studies have shown that PD-1-deficient T reg cells exhibit enhanced immunosuppressive function through reduced signaling through the PI3K-AKT pathway. This finding demonstrates that cell-intrinsic PD-1 restraint of T reg cells is a significant mechanism by which PD-1 inhibitory signals regulate T cell tolerance and autoimmunity.

JOURNAL OF EXPERIMENTAL MEDICINE (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Targeting thioredoxin reductase by deoxyelephantopin from Elephantopus scaber triggers cancer cell apoptosis

Dongzhu Duan et al.

Summary: DET targets TrxR and inhibits its activity, leading to cancer cell apoptosis through oxidative stress. Down-regulation of TrxR1 by shRNA increases cell sensitivity to DET. Targeting of TrxR1 by DET reveals a novel mechanism of action and enhances the potential of DET as a chemotherapeutic agent for cancers.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Prune-1 drives polarization of tumor-associated macrophages (TAMs) within the lung metastatic niche in triple-negative breast cancer

Veronica Ferrucci et al.

Summary: The study suggests that overexpression of Prune-1 in TNBC patients is positively correlated with lung metastasis and infiltrating M2-TAMs. Prune-1 promotes lung metastasis in metastatic TNBC through TGF-beta enhancement, IL-17F secretion, and modulation of extracellular vesicle protein content. Additionally, inactivating gene variants in TNBC patients are found to be involved in immune response, cell adhesion, apoptotic pathways, and DNA repair.

ISCIENCE (2021)

添加到收藏夹

Review Oncology

Exosome-based liquid biopsies in cancer: opportunities and challenges

W. Yu et al.

Summary: Liquid biopsy in cancer research has seen significant progress, with efforts focused on utilizing circulating tumor cells, circulating tumor DNA, and extracellular vesicles like exosomes. Exosomes, as part of the intercellular communication system, carry tumor-derived materials and can serve as stable biomarkers for early detection and monitoring of cancer.

ANNALS OF ONCOLOGY (2021)

添加到收藏夹

Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

添加到收藏夹

Article Cell Biology

The exosomes derived from CAR-T cell efficiently target mesothelin and reduce triple-negative breast cancer growth

Pengxiang Yang et al.

Summary: Exosomes derived from CAR-T cells targeting MSLN showed potential in inhibiting the growth of MSLN-positive triple-negative breast cancer cells, with characteristics similar to parental T cells. The expression of effector molecules may contribute to tumor killing, and in vivo studies demonstrated a highly effective tumor inhibition rate with no obvious side effects. The use of CAR-T cell exosomes has promising therapeutic potential against MSLN-expressing TNBC.

CELLULAR IMMUNOLOGY (2021)

添加到收藏夹

Article Biochemical Research Methods

Enrichment of circulating tumor-derived extracellular vesicles from human plasma

Kathryn E. Yoh et al.

Summary: This study developed an automated method to enrich tumor-derived EVs from plasma using CellSearch technology, demonstrating its efficacy and reliability in detecting specific proteins like PD-L1. Detecting EpCAM+EVs in patients with non-small cell lung carcinoma and triple negative breast cancer suggests that these are tumor-derived EVs.

JOURNAL OF IMMUNOLOGICAL METHODS (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

CircHIF1A regulated by FUS accelerates triple-negative breast cancer progression by modulating NFIB expression and translocation

Tong Chen et al.

Summary: The study found that the novel circRNA circHIF1A was significantly overexpressed in TNBC, associated with metastasis, poor prognosis, and the TNBC subtype. CircHIF1A modulated the expression of NFIB and FUS via a positive feedback loop, leading to activation of the AKT/STAT3 signaling pathway. CircHIF1A may serve as a potential biomarker for breast cancer diagnosis and a therapeutic target for TNBC treatment.

ONCOGENE (2021)

添加到收藏夹

Article Cell Biology

Serum exosomal lncRNA XIST is a potential non-invasive biomarker to diagnose recurrence of triple-negative breast cancer

Fengming Lan et al.

Summary: Serum exosomal XIST levels are significantly increased in recurrent TNBC patients, serving as a potential biomarker for assessing disease load changes and predicting patient prognosis.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)

添加到收藏夹

Article Cell Biology

Proteomic dissection of large extracellular vesicle surfaceome unravels interactive surface platform

Alin Rai et al.

Summary: The surface proteome of extracellular vesicles plays a crucial role in mediating interactions with their environment and serves as a potential source of disease biomarkers and therapeutic targets. This study reveals the surface protein composition of large EVs and highlights the diversity and heterogeneity between different EV subtypes, providing important insights into their functions and molecular complexity.

JOURNAL OF EXTRACELLULAR VESICLES (2021)

添加到收藏夹

Article Cell Biology

Tumor-derived exosomal circPSMA1 facilitates the tumorigenesis, metastasis, and migration in triple-negative breast cancer (TNBC) through miR-637/Akt1/β-catenin (cyclin D1) axis

Su-jin Yang et al.

Summary: This study reveals that circPSMA1 functions as a tumor promoter in triple-negative breast cancer (TNBC) by acting as a miRNA sponge to absorb miR-637 and regulate Akt1-beta-catenin (cyclin D1) axis. Exosomes from TNBC cells carrying high levels of circPSMA1 can transmit migration and proliferation capacity to recipient cells. High expression of Akt1 and low expression of miR-637 are highly correlated with poor prognosis in TNBC patients with lymph node metastasis.

CELL DEATH & DISEASE (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Exosome/Liposome-like Nanoparticles: New Carriers for CRISPR Genome Editing in Plants

Mousa A. Alghuthaymi et al.

Summary: The rapid developments in plant genome editing using CRISPR/Cas systems have led to a need for more detailed exploration of delivery methods. In addition to traditional plasmids and viral vectors, non-viral vectors are also being used, offering advantages such as lower immune response, flexibility in design, and strong targeting capabilities.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

添加到收藏夹

Article Pharmacology & Pharmacy

Cannabidiol loaded extracellular vesicles sensitize triple-negative breast cancer to doxorubicin in both in-vitro and in vivo models

Nilkumar Patel et al.

Summary: CBD encapsulated EVs demonstrated good stability and high encapsulation efficiency, sensitizing MDA-MB-231 cells to doxorubicin in in-vitro studies. The combination of CBD EVs and doxorubicin showed promising results in reducing tumor burden and affecting protein expression related to inflammation, metastasis, and apoptosis, suggesting potential clinical significance in triple-negative breast cancer treatment.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Activated T cell-derived exosomal PD-1 attenuates PD-L1-induced immune dysfunction in triple-negative breast cancer

Yufan Qiu et al.

Summary: The study reveals that PD-1 can be secreted in an exosomal form by activated T cells and interact remotely with PD-L1. This interaction can attenuate the suppression of tumor-specific cytotoxic T cell activity by PD-L1, restoring tumor surveillance.

ONCOGENE (2021)

添加到收藏夹

Article Cell Biology

Exosomal annexin A6 induces gemcitabine resistance by inhibiting ubiquitination and degradation of EGFR in triple-negative breast cancer

Ting Li et al.

Summary: Exosomes derived from resistant cancer cells induce gemcitabine resistance in triple-negative breast cancer cells through upregulating ANXA6 expression, which is associated with the inhibition of EGFR ubiquitination and degradation. Exosomal ANXA6 levels in the serum of patients with TNBC may serve as a predictive factor for response to gemcitabine-based chemotherapy.

CELL DEATH & DISEASE (2021)

添加到收藏夹

Review Cell Biology

Tumor-derived exosomal components: the multifaceted roles and mechanisms in breast cancer metastasis

Yufang Tan et al.

Summary: Exosomes play a crucial role in breast cancer metastasis by altering invasive behavior and organ-specific metastasis of recipient cells. Understanding the significance of tumor-derived exosomal components in breast cancer metastasis is essential for developing novel interventions.

CELL DEATH & DISEASE (2021)

添加到收藏夹

Article Oncology

Tumor Extracellular Vesicles Regulate Macrophage-Driven Metastasis through CCL5

Daniel C. Rabe et al.

Summary: TNBC is a subtype of breast cancer lacking ER, PR, and HER2 receptors. Tumors are infiltrated by TAMs promoting tumorigenesis. Study shows how tumors recruit macrophages through EVs, altering macrophage phenotype and driving metastasis. EVs could serve as biomarkers and play a role in modulating tumor immune response.

CANCERS (2021)

添加到收藏夹

Review Cell Biology

Extracellular vesicles in the development of organ-specific metastasis

Fumihiko Urabe et al.

Summary: Distant organ metastasis, orchestrated by complex biological interactions, is a fundamental feature of malignant tumors. Extracellular vesicles (EVs) play a critical role in mediating tumor-host cell interactions, controlling organ-specific infiltration, adaptation, and colonization at the secondary site.

JOURNAL OF EXTRACELLULAR VESICLES (2021)

添加到收藏夹

Review Biotechnology & Applied Microbiology

Mechanism of cargo sorting into small extracellular vesicles

Yiwen Chen et al.

Summary: Extracellular vesicles are membranous structures released by cells to transport biomolecules and signaling molecules between cells, with small sEVs and larger EVs being the two main types categorized by size. These vesicles are no longer considered waste products, but rather regulators of intercellular communication with specific cargos sorted into them through different mechanisms.

BIOENGINEERED (2021)

添加到收藏夹

Article Biochemical Research Methods

Proteomic Landscape of Exosomes Reveals the Functional Contributions of CD151 in Triple-Negative Breast Cancer

Sipeng Li et al.

Summary: This study revealed the proteomic landscape of TNBC-derived exosomes and discovered that CD151 levels in TNBC-derived exosomes were significantly higher than those in exosomes from healthy subjects. CD151 may be a potential therapeutic target for TNBC.

MOLECULAR & CELLULAR PROTEOMICS (2021)

添加到收藏夹

Article Medicine, Research & Experimental

Phosphatidylserine-exposing tumor-derived microparticles exacerbate coagulation and cancer cell transendothelial migration in triple-negative breast cancer

Cong Zhang et al.

Summary: The study found that neoadjuvant chemotherapy significantly increased the expression of PS+ BCMPs in patient plasma, which was associated with a rapid increase in procoagulant activity. Treatment with lactadherin reduced the adhesion of BCMPs and their procoagulant activity. Injection of BCMPs in mice induced a hypercoagulable state, reducing fibrinogen levels and promoting thrombus formation.

THERANOSTICS (2021)

添加到收藏夹

Article Cell & Tissue Engineering

Delivery of miR-381-3p Mimic by Mesenchymal Stem Cell-Derived Exosomes Inhibits Triple Negative Breast Cancer Aggressiveness; an In Vitro Study

Samaneh Shojaei et al.

Summary: This study demonstrated that ADMSC-exosomes efficiently delivered miR-381 mimic to MDA-MB-231 cells, leading to significant inhibition of proliferation, migration, and invasion capabilities of triple-negative breast cancer cells, while promoting apoptosis. This suggests that ADMSC-exosomes have the potential to be effective nanocarriers for RNA-based therapies.

STEM CELL REVIEWS AND REPORTS (2021)

添加到收藏夹

Review Cell Biology

Extracellular vesicle-associated organotropic metastasis

Zhenzhen Mo et al.

Summary: Metastasis, the dissemination of primary tumor cells, is a major cause of cancer-related deaths. Metastatic organotropism, the specific distribution pattern of distant metastasis, is influenced by various factors. Extracellular vesicles (EVs) play a crucial role in organ-specific metastasis, carrying bioactive cargo that can modulate the pre-metastatic niche and influencing diagnostic and prognostic values. Counteracting EV functions could be a novel therapeutic strategy to target metastasis. More research is needed to understand the mechanisms of EVs in organ-specific metastasis for clinical translation.

CELL PROLIFERATION (2021)

添加到收藏夹

Article Cell & Tissue Engineering

Mesenchymal Stem Cell Derived Exosomes: a Nano Platform for Therapeutics and Drug Delivery in Combating COVID-19

Pinky et al.

Summary: The global pandemic caused by the novel coronavirus strain is a major concern, with efforts being made to find effective treatments. Mesenchymal Stem Cells-derived exosomes are considered a promising therapeutic agent with potential applications in combating the current pandemic.

STEM CELL REVIEWS AND REPORTS (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

ITGB4-mediated metabolic reprogramming of cancer-associated fibroblasts

Jin Sol Sung et al.

ONCOGENE (2020)

添加到收藏夹

Review Cell Biology

Single peptides and combination modalities for triple negative breast cancer

Atefeh Razazan et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2020)

添加到收藏夹

Article Oncology

Differentially expressed microRNAs in exosomes of patients with breast cancer revealed by next-generation sequencing

Heming Wu et al.

ONCOLOGY REPORTS (2020)

添加到收藏夹

Article Oncology

The stromal loss of miR-4516 promotes the FOSL1-dependent proliferation and malignancy of triple negative breast cancer

Ji Eun Kim et al.

CANCER LETTERS (2020)

添加到收藏夹

Article Oncology

Integrin β4-Targeted Cancer Immunotherapies Inhibit Tumor Growth and Decrease Metastasis

Shasha Ruan et al.

CANCER RESEARCH (2020)

添加到收藏夹

Article Oncology

Deubiquitinase Activity Profiling Identifies UCHL1 as a Candidate Oncoprotein That Promotes TGF beta-Induced Breast Cancer Metastasis

Sijia Liu et al.

CLINICAL CANCER RESEARCH (2020)

添加到收藏夹

Article Chemistry, Multidisciplinary

Exosome-mediated siRNA delivery to suppress postoperative breast cancer metastasis

Liuwan Zhao et al.

JOURNAL OF CONTROLLED RELEASE (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Identification of miRNAs Enriched in Extracellular Vesicles Derived from Serum Samples of Breast Cancer Patients

Patricia M. M. Ozawa et al.

BIOMOLECULES (2020)

添加到收藏夹

Review Cell Biology

The Role of Extracellular Vesicles in the Hallmarks of Cancer and Drug Resistance

Cristina P. R. Xavier et al.

CELLS (2020)

添加到收藏夹

Review Pharmacology & Pharmacy

Long noncoding RNA loss in immune suppression in cancer

Qingsong Hu et al.

PHARMACOLOGY & THERAPEUTICS (2020)

添加到收藏夹

Review Oncology

Engineering CAR-T Cells for Next-Generation Cancer Therapy

Mihe Hong et al.

CANCER CELL (2020)

添加到收藏夹

Article Chemistry, Multidisciplinary

Three-Dimensional Human Liver-Chip Emulating Premetastatic Niche Formation by Breast Cancer-Derived Extracellular Vesicles

Junyoung Kim et al.

ACS NANO (2020)

添加到收藏夹

Article Medicine, Research & Experimental

Mechanical strain induces phenotypic changes in breast cancer cells and promotes immunosuppression in the tumor microenvironment

Yong Wang et al.

LABORATORY INVESTIGATION (2020)

添加到收藏夹

Article Oncology

Circulating extracellular vesicles from patients with breast cancer enhance migration and invasion via a Src-dependent pathway in MDA-MB-231 breast cancer cells

Javier Ramirez-Ricardo et al.

MOLECULAR MEDICINE REPORTS (2020)

添加到收藏夹

Review Oncology

Diverse molecular functions of aspartate β-hydroxylase in cancer

Wenqian Zheng et al.

ONCOLOGY REPORTS (2020)

添加到收藏夹

Article Oncology

Targeting IL-3R alpha on tumor-derived endothelial cells blunts metastatic spread of triple-negative breast cancer via extracellular vesicle reprogramming

Tatiana Lopatina et al.

ONCOGENESIS (2020)

添加到收藏夹

Article Cell Biology

LncRNA HAND2-AS1 suppressed the growth of triple negative breast cancer via reducing secretion of MSCs derived exosomal miR-106a-5p

Li Xing et al.

Aging-US (2020)

添加到收藏夹

Article Oncology

Immunosuppressive profiles in liquid biopsy at diagnosis predict response to neoadjuvant chemotherapy in triple-negative breast cancer

Carmen Salvador-Coloma et al.

EUROPEAN JOURNAL OF CANCER (2020)

添加到收藏夹

Article Chemistry, Multidisciplinary

Engineering macrophage-derived exosomes for targeted chemotherapy of triple-negative breast cancer

Sha Li et al.

NANOSCALE (2020)

添加到收藏夹

Article Cell Biology

Heterogeneity of the nucleic acid repertoire of plasma extracellular vesicles demonstrated using high-sensitivity fluorescence-activated sorting

Kirill Kondratov et al.

JOURNAL OF EXTRACELLULAR VESICLES (2020)

添加到收藏夹

Correction Oncology

Serum exosomal-annexin A2 is associated with African-American triple-negative breast cancer and promotes angiogenesis (vol 22, pg 11, 2020)

Pankaj Chaudhary et al.

BREAST CANCER RESEARCH (2020)

添加到收藏夹

Article Cell Biology

Resisting resistance: Homing in on better immunotherapy responses

Patrick M. Brunner

Science Translational Medicine (2019)

添加到收藏夹

Review Immunology

PD-1 Tumor Suppressor Signaling in T Cell Lymphomas

Tim Wartewig et al.

TRENDS IN IMMUNOLOGY (2019)

添加到收藏夹

Review Pharmacology & Pharmacy

Exosomes and their role in tumorigenesis and anticancer drug resistance

Neta Milman et al.

DRUG RESISTANCE UPDATES (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

Triple-negative breast cancer-derived microvesicles transfer microRNA221 to the recipient cells and thereby promote epithelial-to-mesenchymal transition

Kaushik Das et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

Cisplatin-resistant MDA-MB-231 Cell-derived Exosomes Increase the Resistance of Recipient Cells in an Exosomal miR-423-5p-dependent Manner

Bing Wang et al.

CURRENT DRUG METABOLISM (2019)

添加到收藏夹

Article Biology

Distinct mechanisms of microRNA sorting into cancer cell-derived extracellular vesicle subtypes

Morayma M. Temoche-Diaz et al.

ELIFE (2019)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Functional exosome-mediated co-delivery of doxorubicin and hydrophobically modified microRNA 159 for triple-negative breast cancer therapy

Chunai Gong et al.

JOURNAL OF NANOBIOTECHNOLOGY (2019)

添加到收藏夹

Article Oncology

HPV DNA Associates With Breast Cancer Malignancy and It Is Transferred to Breast Cancer Stromal Cells by Extracellular Vesicles

Sabrina De Carolis et al.

FRONTIERS IN ONCOLOGY (2019)

添加到收藏夹

Article Oncology

Targeted exosome-encapsulated erastin induced ferroptosis in triple negative breast cancer cells

Mengyu Yu et al.

CANCER SCIENCE (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

ASPH-notch Axis guided Exosomal delivery of Prometastatic Secretome renders breast Cancer multi-organ metastasis

Qiushi Lin et al.

MOLECULAR CANCER (2019)

添加到收藏夹

Article Multidisciplinary Sciences

CAR exosomes derived from effector CAR-T cells have potent antitumour effects and low toxicity

Wenyan Fu et al.

NATURE COMMUNICATIONS (2019)

添加到收藏夹

Article Multidisciplinary Sciences

Cancer Testis Antigen Promotes Triple Negative Breast Cancer Metastasis and is Traceable in the Circulating Extracellular Vesicles

Anbarasu Kannan et al.

SCIENTIFIC REPORTS (2019)

添加到收藏夹

Review Oncology

The clinical role of the TME in solid cancer

Nicolas A. Giraldo et al.

BRITISH JOURNAL OF CANCER (2019)

添加到收藏夹

Review Pharmacology & Pharmacy

Extracellular vesicles as a novel source of biomarkers in liquid biopsies for monitoring cancer progression and drug resistance

M. Helena Vasconcelos et al.

DRUG RESISTANCE UPDATES (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

Evaluation of exosomal miR-9 and miR-155 targeting PTEN and DUSP14 in highly metastatic breast cancer and their effect on low metastatic cells

Vahid Kia et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2019)

添加到收藏夹

Review Obstetrics & Gynecology

Triple-negative breast cancer: current perspective on the evolving therapeutic landscape

Joe Mehanna et al.

INTERNATIONAL JOURNAL OF WOMENS HEALTH (2019)

添加到收藏夹

Review Oncology

Extracellular vesicles in cancer - implications for future improvements in cancer care

Rong Xu et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2018)

添加到收藏夹

Article Cell Biology

MiR-770 suppresses the chemo-resistance and metastasis of triple negative breast cancer via direct targeting of STMN1

Yaming Li et al.

CELL DEATH & DISEASE (2018)

添加到收藏夹

Review Oncology

Long non-coding RNAs: implications in targeted diagnoses, prognosis, and improved therapeutic strategies in human non-and triple-negative breast cancer

Ruben Rodriguez Bautista et al.

CLINICAL EPIGENETICS (2018)

添加到收藏夹

Article Medicine, General & Internal

Specific microRNA signatures in exosomes of triple-negative and HER2-positive breast cancer patients undergoing neoadjuvant therapy within the GeparSixto trial

Ines Stevic et al.

BMC MEDICINE (2018)

添加到收藏夹

Article Oncology

Extracellular vesicles from triple-negative breast cancer cells promote proliferation and drug resistance in non-tumorigenic breast cells

Patricia Midori Murobushi Ozawa et al.

BREAST CANCER RESEARCH AND TREATMENT (2018)

添加到收藏夹

Article Oncology

The Role of Arrestin Domain-Containing 3 in Regulating Endocytic Recycling and Extracellular Vesicle Sorting of Integrin β4 in Breast Cancer

Young Hwa Soung et al.

CANCERS (2018)

添加到收藏夹

Review Biotechnology & Applied Microbiology

MicroRNA therapeutics: towards a new era for the management of cancer and other diseases

Rajesha Rupaimoole et al.

NATURE REVIEWS DRUG DISCOVERY (2017)

添加到收藏夹

Article

Breast cancer cell-derived exosomes and macrophage polarization are associated with lymph node metastasis

Yin Ji Piao et al.

Oncotarget (2017)

添加到收藏夹

Article Pharmacology & Pharmacy

Phytoagent Deoxyelephantopin and Its Derivative Inhibit Triple Negative Breast Cancer Cell Activity through ROS- Mediated Exosomal Activity and Protein Functions

Jeng-Yuan Shiau et al.

FRONTIERS IN PHARMACOLOGY (2017)

添加到收藏夹

Article Oncology

Breast cancer-secreted miR-939 downregulates VE-cadherin and destroys the barrier function of endothelial monolayers

Martina Di Modica et al.

CANCER LETTERS (2017)

添加到收藏夹

Article Oncology

Extracellular Vesicles in Cancer: Cell-to-Cell Mediators of Metastasis

Annette Becker et al.

CANCER CELL (2016)

添加到收藏夹

Article Medicine, Research & Experimental

Human CAR T cells with cell-intrinsic PD-1 checkpoint blockade resist tumor-mediated inhibition

Leonid Cherkassky et al.

JOURNAL OF CLINICAL INVESTIGATION (2016)

添加到收藏夹

Article Multidisciplinary Sciences

Regulated delivery of molecular cargo to invasive tumour-derived microvesicles

James W. Clancy et al.

NATURE COMMUNICATIONS (2015)

添加到收藏夹

Article Oncology

Exosomes from triple-negative breast cancer cells can transfer phenotypic traits representing their cells of origin to secondary cells

Keith O'Brien et al.

EUROPEAN JOURNAL OF CANCER (2013)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.