期刊
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
卷 10, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fcell.2022.852752
关键词
microglia; microRNA; DNA methylation; zebrafish; rodents; fetal alcohol syndrome; autism spectrum disorders; Rett syndrome
Neuroinflammation is linked to epigenetic dysregulation and may contribute to neurodevelopmental disorders. Understanding the role of epigenetics in microglia is crucial for studying neuroinflammation, and research using both mammals and zebrafish is valuable.
Neuroinflammation is a cause of neurodevelopmental disorders such as autism spectrum disorders, fetal alcohol syndrome, and cerebral palsy. Converging lines of evidence from basic and clinical sciences suggest that dysregulation of the epigenetic landscape, including DNA methylation and miRNA expression, is associated with neuroinflammation. Genetic and environmental factors can affect the interaction between epigenetics and neuroinflammation, which may cause neurodevelopmental disorders. In this minireview, we focus on neuroinflammation that might be mediated by epigenetic dysregulation in microglia, and compare studies using mammals and zebrafish.
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