Expression of Retinal G Protein-Coupled Receptor, a Member of the Opsin Family, in Human Skin Cells and Its Mediation of the Cellular Functions of Keratinocytes

Article Dermatology

Opsin 5 is a key regulator of ultraviolet radiation-induced melanogenesis in human epidermal melanocytes

Y. Lan et al.

Summary: This study reveals that OPN5 acts as a key sensor in melanocytes, mediating UVR-induced melanogenesis through Ca2+-dependent signaling pathways. The activation of OPN5 is essential for the increase in cellular melanin induced by UVR.

BRITISH JOURNAL OF DERMATOLOGY (2021)

添加到收藏夹

Article Dermatology

TGFβ2 Upregulates Tyrosinase Activity through Opsin-3 in Human Skin Melanocytes In Vitro

Yu Wang et al.

Summary: The study suggests that TGF beta 2 regulates melanogenesis in human melanocytes through OPN3 and downstream signaling pathways, independently of the TGF beta 2 receptor. Inhibition of OPN3 affects TYR activity and expression of TRP-1 and TRP-2 in melanocytes, indicating its role in melanin synthesis.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2021)

添加到收藏夹

Article Pathology

Human RGR Gene and Associated Features of Age-Related Macular Degeneration in Models of Retina-Choriocapillaris Atrophy

Xuan Bao et al.

Summary: Age-related macular degeneration is a progressive eye disease that is the leading cause of blindness in elderly individuals. The disease is characterized by the formation of extracellular deposits known as drusen between the retinal pigment epithelium and Bruch membrane. Research suggests that abnormal RGR proteins, such as RGR-d, may play a pathogenic role in the degeneration of the choriocapillaris, retinal pigment epithelium, and photoreceptors, leading to potential vision loss.

AMERICAN JOURNAL OF PATHOLOGY (2021)

添加到收藏夹

Article Biology

Evolutionary Constraint on Visual and Nonvisual Mammalian Opsins

Brian A. Upton et al.

Summary: Through analyzing genomic data from over 400 mammalian species from 22 orders, this study identified unique patterns of evolution for each mammalian opsins, highlighting the varying degrees of sequence conservation and lineage-specific gene loss. The findings demonstrate extreme conservation for OPN5 and rhodopsin across all mammalian lineages, while showing moderate conservation for cone opsins, nonvisual opsins, and high sequence diversity for photoisomerase and the well-studied atypical opsin, OPN4, within mammals. These conservation patterns are maintained in human populations, indicating the importance of key amino acid residues for retinal-based chromophores in all mammalian opsins. Further discussions on the functions of each atypical opsins provide insight into the observed patterns of evolutionary constraint in circadian or metabolic physiology.

JOURNAL OF BIOLOGICAL RHYTHMS (2021)

添加到收藏夹

Review Cell Biology

Opsins outside the eye and the skin: a more complex scenario than originally thought for a classical light sensor

Maria Nathalia Moraes et al.

Summary: Opsins have been found in organs and cells beyond light-exposed tissues, indicating functions beyond light-sensing including thermal detection. Recent studies, particularly in mammals, focus on understanding the role of opsins in peripheral tissues.

CELL AND TISSUE RESEARCH (2021)

添加到收藏夹

Article Dermatology

Opsin 3 is a key regulator of ultraviolet A-induced photoageing in human dermal fibroblast cells

Y. Lan et al.

BRITISH JOURNAL OF DERMATOLOGY (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Opsin3 Downregulation Induces Apoptosis of Human Epidermal Melanocytes via Mitochondrial Pathway

Yu Wang et al.

PHOTOCHEMISTRY AND PHOTOBIOLOGY (2020)

添加到收藏夹

Article Cell Biology

OPN4 belongs to the photosensitive system of the human skin

Junya Kusumoto et al.

GENES TO CELLS (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Melanopsin mediates UVA-dependent modulation of proliferation, pigmentation, apoptosis, and molecular clock in normal and malignant melanocytes

Leonardo Vinicius Monteiro de Assis et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2020)

添加到收藏夹

Article Neurosciences

Light-Driven Regeneration of Cone Visual Pigments through a Mechanism Involving RGR Opsin in Muller Glial Cells

Ala Morshedian et al.

NEURON (2019)

添加到收藏夹

Article Multidisciplinary Sciences

Human nonvisual opsin 3 regulates pigmentation of epidermal melanocytes through functional interaction with melanocortin 1 receptor

Rana N. Ozdeslik et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

添加到收藏夹

Article Pathology

Analyses of molecular and histopathologic features and expression of PRAME by immunohistochemistry in mucosal melanomas

Aimi Toyama et al.

MODERN PATHOLOGY (2019)

添加到收藏夹

Article Cell Biology

Melanopsin and rhodopsin mediate UVA-induced immediate pigment darkening: Unravelling the photosensitive system of the skin

Leonardo Vinicius Monteiro de Assis et al.

EUROPEAN JOURNAL OF CELL BIOLOGY (2018)

添加到收藏夹

Article Dermatology

Melanocytes Sense Blue Light and Regulate Pigmentation through Opsin-3

Claire Regazzetti et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2018)

添加到收藏夹

Article Multidisciplinary Sciences

External light activates hair follicle stem cells through eyes via an ipRGC-SCN-sympathetic neural pathway

Sabrina Mai-Yi Fan et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

添加到收藏夹

Review Endocrinology & Metabolism

How UV Light Touches the Brain and Endocrine System Through Skin, and Why

Andrzej T. Slominski et al.

ENDOCRINOLOGY (2018)

添加到收藏夹

Article Gastroenterology & Hepatology

Blue light-emitting diodes induce autophagy in colon cancer cells by Opsin 3

Toshiaki Yoshimoto et al.

ANNALS OF GASTROENTEROLOGICAL SURGERY (2018)

添加到收藏夹

Article Biochemistry & Molecular Biology

Opsin Expression in Human Epidermal Skin

Kirk Haltaufderhyde et al.

PHOTOCHEMISTRY AND PHOTOBIOLOGY (2015)

添加到收藏夹

Review Chemistry, Multidisciplinary

Chemistry of the Retinoid (Visual) Cycle

Philip D. Kiser et al.

CHEMICAL REVIEWS (2014)

添加到收藏夹

Article Multidisciplinary Sciences

Violet Light Down-Regulates the Expression of Specific Differentiation Markers through Rhodopsin in Normal Human Epidermal Keratinocytes

Hyoung-June Kim et al.

PLOS ONE (2013)

添加到收藏夹

Article Oncology

Opsin3 sensitizes hepatocellular carcinoma cells to 5-fluorouracil treatment by regulating the apoptotic pathway

Jianhua Jiao et al.

CANCER LETTERS (2012)

添加到收藏夹

Article Biochemistry & Molecular Biology

UVA Phototransduction Drives Early Melanin Synthesis in Human Melanocytes

Nadine L. Wicks et al.

CURRENT BIOLOGY (2011)

添加到收藏夹

Review Biochemistry & Molecular Biology

Phototransduction Motifs and Variations

King-Wai Yau et al.

CELL (2009)

添加到收藏夹

Article Dermatology

Expressions of rod and cone photoreceptor-like proteins in human epidermis

Moe Tsutsumi et al.

EXPERIMENTAL DERMATOLOGY (2009)

添加到收藏夹

Review Biochemistry & Molecular Biology

The opsins of the vertebrate retina: insights from structural, biochemical, and evolutionary studies

B. Nickle et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2007)

添加到收藏夹

Article Multidisciplinary Sciences

A rhodopsin exhibiting binding ability to agonist all-trans-retinal

H Tsukamoto et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

添加到收藏夹

Review Biotechnology & Applied Microbiology

The opsins

A Terakita

GENOME BIOLOGY (2005)

添加到收藏夹

Article Biochemistry & Molecular Biology

Evaluation of the role of the retinal G protein-coupled receptor (RGR) in the vertebrate retina in vivo

T Maeda et al.

JOURNAL OF NEUROCHEMISTRY (2003)

添加到收藏夹

Article Multidisciplinary Sciences

Role of the conserved NPxxY(x)5,6F motif in the rhodopsin ground state and during activation

O Fritze et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

添加到收藏夹

Letter Genetics & Heredity

A photic visual cycle of rhodopsin regeneration is dependent on Rgr

P Chen et al.

NATURE GENETICS (2001)

添加到收藏夹

Expression of Retinal G Protein-Coupled Receptor, a Member of the Opsin Family, in Human Skin Cells and Its Mediation of the Cellular Functions of Keratinocytes

相关参考文献

导出引文

分享论文