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RNautophagy/DNautophagy possesses selectivity for RNA/DNA substrates
Katsunori Hase et al.
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MITF drives endolysosomal biogenesis and potentiates Wnt signaling in melanoma cells
Diego Ploper et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
TDP-43 repression of nonconserved cryptic exons is compromised in ALS-FTD
Jonathan P. Ling et al.
SCIENCE (2015)
Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways
Elizabeth T. Cirulli et al.
SCIENCE (2015)
A FYVE zinc finger domain protein specifically links mRNA transport to endosome trafficking
Thomas Pohlmann et al.
ELIFE (2015)
C9ORF72 expression and cellular localization over mouse development
Rachel A. K. Atkinson et al.
ACTA NEUROPATHOLOGICA COMMUNICATIONS (2015)
ALS-associated mutant FUS inhibits macroautophagy which is restored by overexpression of Rab1
K. Y. Soo et al.
CELL DEATH DISCOVERY (2015)
MTOR-independent, autophagic enhancer trehalose prolongs motor neuron survival and ameliorates the autophagic flux defect in a mouse model of amyotrophic lateral sclerosis
Xiaojie Zhang et al.
AUTOPHAGY (2014)
The autophagic roles of Rab small GTPases and their upstream regulators A review
Zsuzsanna Szatmari et al.
AUTOPHAGY (2014)
Inhibition of autophagy, lysosome and VCP function impairs stress granule assembly
S. J. Seguin et al.
CELL DEATH AND DIFFERENTIATION (2014)
Novel roles for the MiTF/TFE family of transcription factors in organelle biogenesis, nutrient sensing, and energy homeostasis
Jose A. Martina et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2014)
C9ORF72, implicated in amytrophic lateral sclerosis and frontotemporal dementia, regulates endosomal trafficking
Manal A. Farg et al.
HUMAN MOLECULAR GENETICS (2014)
Spastic paraplegia proteins spastizin and spatacsin mediate autophagic lysosome reformation
Jaerak Chang et al.
JOURNAL OF CLINICAL INVESTIGATION (2014)
Autophagy dysregulation in cell culture and animals models of spinal muscular atrophy
Sara K. Custer et al.
MOLECULAR AND CELLULAR NEUROSCIENCE (2014)
C9orf72 nucleotide repeat structures initiate molecular cascades of disease
Aaron R. Haeusler et al.
NATURE (2014)
Autophagy induction enhances TDP43 turnover and survival in neuronal ALS models
Sami J. Barmada et al.
NATURE CHEMICAL BIOLOGY (2014)
Autophagy regulates amyotrophic lateral sclerosis-linked fused in sarcoma-positive stress granules in neurons
Hyun-Hee Ryu et al.
NEUROBIOLOGY OF AGING (2014)
Exome-wide Rare Variant Analysis Identifies TUBA4A Mutations Associated with Familial ALS
Bradley N. Smith et al.
NEURON (2014)
Resveratrol Improves Motoneuron Function and Extends Survival in SOD1G93A ALS Mice
Renzo Mancuso et al.
NEUROTHERAPEUTICS (2014)
Direct conversion of patient fibroblasts demonstrates non-cell autonomous toxicity of astrocytes to motor neurons in familial and sporadic ALS
Kathrin Meyer et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
C9orf72 repeat expansions cause neurodegeneration in Drosophila through arginine-rich proteins
Sarah Mizielinska et al.
SCIENCE (2014)
Progranulin in neurodegenerative disease
Terri L. Petkau et al.
TRENDS IN NEUROSCIENCES (2014)
Retromer: A Master Conductor of Endosome Sorting
Christopher Burd et al.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2014)
Autophagy supports genomic stability by degrading retrotransposon RNA
Huishan Guo et al.
NATURE COMMUNICATIONS (2014)
ER-mitochondria associations are regulated by the VAPB-PTPIP51 interaction and are disrupted by ALS/FTD-associated TDP-43
Radu Stoica et al.
NATURE COMMUNICATIONS (2014)
RNA-Processing Protein TDP-43 Regulates FOXO-Dependent Protein Quality Control in Stress Response
Tao Zhang et al.
PLOS GENETICS (2014)
A High-Content Screen Identifies Novel Compounds That Inhibit Stress-Induced TDP-43 Cellular Aggregation and Associated Cytotoxicity
Justin D. Boyd et al.
JOURNAL OF BIOMOLECULAR SCREENING (2014)
C9orf72 frontotemporal lobar degeneration is characterised by frequent neuronal sense and antisense RNA foci
Sarah Mizielinska et al.
ACTA NEUROPATHOLOGICA (2013)
Discovery of a novel type of autophagy targeting RNA
Yuuki Fujiwara et al.
AUTOPHAGY (2013)
Eukaryotic Stress Granules Are Cleared by Autophagy and Cdc48/VCP Function
J. Ross Buchan et al.
CELL (2013)
Dual Specificity Kinase DYRK3 Couples Stress Granule Condensation/Dissolution to mTORC1 Signaling
Frank Wippich et al.
CELL (2013)
A cellular model for sporadic ALS using patient-derived induced pluripotent stem cells
Matthew F. Burkhardt et al.
MOLECULAR AND CELLULAR NEUROSCIENCE (2013)
Tau pathology and neurodegeneration
Maria Grazia Spillantini et al.
LANCET NEUROLOGY (2013)
Amyotrophic lateral sclerosis-linked FUS/TLS alters stress granule assembly and dynamics
Desiree M. Baron et al.
MOLECULAR NEURODEGENERATION (2013)
Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS
Hong Joo Kim et al.
NATURE (2013)
The role of autophagy in neurodegenerative disease
Ralph A. Nixon
NATURE MEDICINE (2013)
A novel phosphorylation site mutation in profilin 1 revealed in a large screen of US, Nordic, and German amyotrophic lateral sclerosis/frontotemporal dementia cohorts
Caroline Ingre et al.
NEUROBIOLOGY OF AGING (2013)
PFN1 mutations are rare in Han Chinese populations with amyotrophic lateral sclerosis
YongPing Chen et al.
NEUROBIOLOGY OF AGING (2013)
Clinicopathologic variability of the GRN A9D mutation, including amyotrophic lateral sclerosis
Ashley Cannon et al.
NEUROLOGY (2013)
Converging Mechanisms in ALS and FTD: Disrupted RNA and Protein Homeostasis
Shuo-Chien Ling et al.
NEURON (2013)
Survival motor neuron protein reduction deregulates autophagy in spinal cord motoneurons in vitro
A. Garcera et al.
CELL DEATH & DISEASE (2013)
Clinico-pathological features in amyotrophic lateral sclerosis with expansions in C9ORF72
Johnathan Cooper-Knock et al.
BRAIN (2012)
Insights into RNA Biology from an Atlas of Mammalian mRNA-Binding Proteins
Alfredo Castello et al.
CELL (2012)
RGG motif proteins Modulators of mRNA functional states
Purusharth Rajyaguru et al.
CELL CYCLE (2012)
A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB
Carmine Settembre et al.
EMBO JOURNAL (2012)
VAPB interacts with the mitochondrial protein PTPIP51 to regulate calcium homeostasis
Kurt J. De Vos et al.
HUMAN MOLECULAR GENETICS (2012)
TBK-1 Promotes Autophagy-Mediated Antimicrobial Defense by Controlling Autophagosome Maturation
Manohar Pilli et al.
IMMUNITY (2012)
Transient Sequestration of TORC1 into Stress Granules during Heat Stress
Terunao Takahara et al.
MOLECULAR CELL (2012)
The TOR Complex 1 Is a Direct Target of Rho1 GTPase
Gonghong Yan et al.
MOLECULAR CELL (2012)
Frequency of the C9orf72 hexanucleotide repeat expansion in patients with amyotrophic lateral sclerosis and frontotemporal dementia: a cross-sectional study
Elisa Majounie et al.
LANCET NEUROLOGY (2012)
Modulation of glutamine metabolism by the PI(3)K-PKB-FOXO network regulates autophagy
Kristan E. van der Vos et al.
NATURE CELL BIOLOGY (2012)
SMN1 gene duplications are associated with sporadic ALS
H. M. Blauw et al.
NEUROLOGY (2012)
SQSTM1 mutations in frontotemporal lobar degeneration and amyotrophic lateral sclerosis
Elisa Rubino et al.
NEUROLOGY (2012)
Microglial Activation Correlates with Disease Progression and Upper Motor Neuron Clinical Symptoms in Amyotrophic Lateral Sclerosis
Johannes Brettschneider et al.
PLOS ONE (2012)
Astrocyte dysfunction triggers neurodegeneration in a lysosomal storage disorder
Chiara Di Malta et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Autophagy activators rescue and alleviate pathogenesis of a mouse model with proteinopathies of the TAR DNA-binding protein 43
I-Fang Wang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Phosphatidylinositol-3,5-Bisphosphate: No Longer the Poor PIP2
Cheuk Y. Ho et al.
TRAFFIC (2012)
C9orf72 hexanucleotide repeat associated with amyotrophic lateral sclerosis and frontotemporal dementia forms RNA G-quadruplexes
Pietro Fratta et al.
SCIENTIFIC REPORTS (2012)
p62 positive, TDP-43 negative, neuronal cytoplasmic and intranuclear inclusions in the cerebellum and hippocampus define the pathology of C9orf72-linked FTLD and MND/ALS
Safa Al-Sarraj et al.
ACTA NEUROPATHOLOGICA (2011)
Clinical and neuropathologic heterogeneity of c9FTD/ALS associated with hexanucleotide repeat expansion in C9ORF72
Melissa E. Murray et al.
ACTA NEUROPATHOLOGICA (2011)
SQSTM1 Mutations in Familial and Sporadic Amyotrophic Lateral Sclerosis
Faisal Fecto et al.
ARCHIVES OF NEUROLOGY (2011)
Seeing is believing The impact of electron microscopy on autophagy research
Eeva-Liisa Eskelinen et al.
AUTOPHAGY (2011)
Rapamycin treatment augments motor neuron degeneration in SOD1G93A mouse model of amyotrophic lateral sclerosis
Xiaojie Zhang et al.
AUTOPHAGY (2011)
Distinct pathogenic processes between Fig4-deficient motor and sensory neurons
Istvan Katona et al.
EUROPEAN JOURNAL OF NEUROSCIENCE (2011)
Downregulation of VAPB expression in motor neurons derived from induced pluripotent stem cells of ALS8 patients
Miguel Mitne-Neto et al.
HUMAN MOLECULAR GENETICS (2011)
Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways
Michela Palmieri et al.
HUMAN MOLECULAR GENETICS (2011)
Identification of Neuronal RNA Targets of TDP-43-containing Ribonucleoprotein Complexes
Chantelle F. Sephton et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Regulation of Autophagy by Neuropathological Protein TDP-43
Jayarama Krishnan Bose et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
DENN Domain Proteins: Regulators of Rab GTPases
Andrea L. Marat et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Making Connections: Pathology and Genetics Link Amyotrophic Lateral Sclerosis with Frontotemporal Lobe Dementia
Faisal Fecto et al.
JOURNAL OF MOLECULAR NEUROSCIENCE (2011)
TDP-43 Is Directed to Stress Granules by Sorbitol, a Novel Physiological Osmotic and Oxidative Stressor
Colleen M. Dewey et al.
MOLECULAR AND CELLULAR BIOLOGY (2011)
Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia
Han-Xiang Deng et al.
NATURE (2011)
Astrocytes from familial and sporadic ALS patients are toxic to motor neurons
Amanda M. Haidet-Phillips et al.
NATURE BIOTECHNOLOGY (2011)
Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43
Magdalini Polymenidou et al.
NATURE NEUROSCIENCE (2011)
Expanded GGGGCC Hexanucleotide Repeat in Noncoding Region of C9ORF72 Causes Chromosome 9p-Linked FTD and ALS
Mariely DeJesus-Hernandez et al.
NEURON (2011)
A Hexanucleotide Repeat Expansion in C9ORF72 Is the Cause of Chromosome 9p21-Linked ALS-FTD
Alan E. Renton et al.
NEURON (2011)
rnaset2 mutant zebrafish model familial cystic leukoencephalopathy and reveal a role for RNase T2 in degrading ribosomal RNA
Noemie Haud et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Phosphorylation of the Autophagy Receptor Optineurin Restricts Salmonella Growth
Philipp Wild et al.
SCIENCE (2011)
Sigma Nonopioid Intracellular Receptor 1 Mutations Cause Frontotemporal Lobar Degeneration-Motor Neuron Disease
Agnes A. Luty et al.
ANNALS OF NEUROLOGY (2010)
SPATACSIN mutations cause autosomal recessive juvenile amyotrophic lateral sclerosis
Antonio Orlacchio et al.
BRAIN (2010)
Ubiquilin functions in autophagy and is degraded by chaperone-mediated autophagy
Cara Rothenberg et al.
HUMAN MOLECULAR GENETICS (2010)
Mutations of optineurin in amyotrophic lateral sclerosis
Hirofumi Maruyama et al.
NATURE (2010)
Vesicle associated membrane protein B (VAPB) is decreased in ALS spinal cord
Georgia Anagnostou et al.
NEUROBIOLOGY OF AGING (2010)
Genetic contribution of FUS to frontotemporal lobar degeneration
T. Van Langenhove et al.
NEUROLOGY (2010)
Exome Sequencing Reveals VCP Mutations as a Cause of Familial ALS
Jane O. Johnson et al.
NEURON (2010)
Mutations in CHMP2B in Lower Motor Neuron Predominant Amyotrophic Lateral Sclerosis (ALS)
Laura E. Cox et al.
PLOS ONE (2010)
Loss of ALS2/Alsin Exacerbates Motor wDysfunction in a SOD1H46R-Expressing Mouse ALS Model by Disturbing Endolysosomal Trafficking
Shinji Hadano et al.
PLOS ONE (2010)
The proteome of lysosomes
Bernd A. Schroeder et al.
PROTEOMICS (2010)
Deleterious Variants of FIG4. a Phosphoinositide Phosphatase, in Patients with ALS
Clement Y. Chow et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2009)
ESCRTs and human disease
Suraj Saksena et al.
BIOCHEMICAL SOCIETY TRANSACTIONS (2009)
The Many Pathways of RNA Degradation
Jonathan Houseley et al.
CELL (2009)
Defective autophagy in neurons and astrocytes from mice deficient in PI(3,5)P2
Cole J. Ferguson et al.
HUMAN MOLECULAR GENETICS (2009)
VCP Mutations Causing Frontotemporal Lobar Degeneration Disrupt Localization of TDP-43 and Induce Cell Death
Michael A. Gitcho et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Rapamycin Rescues TDP-43 Mislocalization and the Associated Low Molecular Mass Neurofilament Instability
Antonella Caccamo et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Rab GTPases as coordinators of vesicle traffic
Harald Stenmark
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2009)
A Gene Network Regulating Lysosomal Biogenesis and Function
Marco Sardiello et al.
SCIENCE (2009)
Mutations in FUS, an RNA Processing Protein, Cause Familial Amyotrophic Lateral Sclerosis Type 6
Caroline Vance et al.
SCIENCE (2009)
Coordinate activation of autophagy and the proteasome pathway by FoxO transcription factor
Jinghui Zhao et al.
AUTOPHAGY (2008)
Motor neuron disease occurring in a mutant dynactin mouse model is characterized by defects in vesicular trafficking
Fiona M. Laird et al.
JOURNAL OF NEUROSCIENCE (2008)
The Atg16L complex specifies the site of LC3 lipidation for membrane biogenesis in autophagy
Naonobu Fujita et al.
MOLECULAR BIOLOGY OF THE CELL (2008)
Lithium delays progression of amyotrophic lateral sclerosis
Francesco Fornai et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis
Jemeen Sreedharan et al.
SCIENCE (2008)
FoxO3 controls autophagy in skeletal muscle in vivo
Cristina Mammucari et al.
CELL METABOLISM (2007)
TDP-43 proteinopathy in frontotemporal lobar degeneration and amyotrophic lateral sclerosis - Protein misfolding diseases without amyloidosis
Manuela Neumann et al.
ARCHIVES OF NEUROLOGY (2007)
A reassessment of the neuropathology of frontotemporal dementia linked to chromosome 3
Ida Elisabeth Holm et al.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2007)
p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy
Serhiy Pankiv et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Progranulin mutations and amyotrophic lateral sclerosis or amyotrophic lateral sclerosis-frontotemporal dementia phenotypes
J. C. Schymick et al.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2007)
ALS phenotypes with mutations in CHMP2B (charged multivesicular body protein 2B)
N. Parkinson et al.
NEUROLOGY (2006)
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Matt Baker et al.
NATURE (2006)
Null mutations in progranulin cause ubiquitin-positive frontotemporal dementia linked to chromosome 17q21
Marc Cruts et al.
NATURE (2006)
Mutations in the endosomal ESCRTIII-complex subunit CHMP2B in frontotemporal dementia
G Skibinski et al.
NATURE GENETICS (2005)
A mutation in the vesicle-trafficking protein VAPB causes late-onset spinal muscular atrophy and amyotrophic lateral sclerosis
AL Nishimura et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2004)
ALS2, a novel guanine nucleotide exchange factor for the small GTPase Rab5, is implicated in endosomal dynamics
A Otomo et al.
HUMAN MOLECULAR GENETICS (2003)
The gene encoding alsin, a protein with three guanine-nucleotide exchange factor domains, is mutated in a form of recessive amyotrophic lateral sclerosis
Y Yang et al.
NATURE GENETICS (2001)
A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2
S Hadano et al.
NATURE GENETICS (2001)
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