☆ 4.7 Article

The Pyroptosis-Related Long Noncoding RNA Signature Predicts Prognosis and Indicates Immunotherapeutic Efficiency in Hepatocellular Carcinoma

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2022)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Gastroenterology & Hepatology

A prognostic model for hepatocellular carcinoma patients based on signature ferroptosis-related genes

Sizhe Wan et al.

Summary: An prognostic model based on ferroptosis-related genes was successfully established using RNA-seq and clinical data of HCC patients. The model incorporates risk score, TNM stage, and cirrhosis to predict the survival of HCC patients. The difference in overall survival between risk groups was found to be closely related to immune-related pathways, suggesting that an immune-suppressive tumor microenvironment may influence the prognosis of HCC patients.

HEPATOLOGY INTERNATIONAL (2022)

添加到收藏夹

Article Surgery

A Somatic Mutation-Derived LncRNA Signature of Genomic Instability Predicts Prognosis for Patients With Liver Cancer

Cheng Guo et al.

Summary: This study identified seven genomic instability-related lncRNAs to define a prognostic signature for HCC patients, showing significant differences in survival between high- and low-risk groups. The GILncSig was validated as an independent risk factor for HCC patients and could predict survival rate in the 1st, 3rd, and 5th years. The signature also showed potential in guiding clinical treatment decisions based on immune cell infiltration levels.

FRONTIERS IN SURGERY (2021)

添加到收藏夹

Article Cell Biology

Construction of a genome instability-derived lncRNA-based risk scoring system for the prognosis of hepatocellular carcinoma

Dan-Ping Huang et al.

Aging-US (2021)

添加到收藏夹

Article Oncology

Identification and characterization of a 25-lncRNA prognostic signature for early recurrence in hepatocellular carcinoma

Yi Fu et al.

Summary: Our study established a 25-lncRNA prognostic signature for predicting early recurrence in HCC patients, which may guide postoperative treatment and recurrence surveillance. The combination of this signature with AFP, TNM, and vascular invasion can significantly improve the predictive performance for early recurrence in HCC. Moreover, gene set enrichment analysis revealed potential pathways associated with high-risk group, while differences in tumor infiltrating lymphocytes levels and immune therapy responses were observed between low- and high-risk groups.

BMC CANCER (2021)

添加到收藏夹

Article Medicine, Research & Experimental

A novel immune classification reveals distinct immune escape mechanism and genomic alterations: implications for immunotherapy in hepatocellular carcinoma

Zaoqu Liu et al.

Summary: The study identified three distinct tumor immunological microenvironment (TIME) phenotypes in hepatocellular carcinoma, each with different clinical outcomes, immune escape mechanisms, and genomic alterations. These findings may offer strategies to improve the efficacy of immunotherapy. Time index (TI) was proposed as a novel prognostic and immunotherapeutic signature to guide personalized immunotherapy and clinical management of HCC.

JOURNAL OF TRANSLATIONAL MEDICINE (2021)

添加到收藏夹

Article Oncology

Long non-coding RNA ZFPM2-AS1 promotes colorectal cancer progression by sponging miR-137 to regulate TRIM24

Meihua Xiao et al.

Summary: In colorectal cancer (CRC), ZFPM2-AS1 may act as an oncogene by regulating the miR-137/TRIM24 axis, and its upregulation is significantly associated with tumor size, histological differentiation, lymph node metastasis, and TNM stage.

MOLECULAR MEDICINE REPORTS (2021)

添加到收藏夹

Review Cell Biology

Gene regulation by long non-coding RNAs and its biological functions

Luisa Statello et al.

Summary: Recent studies have shed new light on the biogenesis and functions of long non-coding RNAs (lncRNAs), showcasing their diverse roles in gene regulation and signaling pathways, particularly in the contexts of neuronal disorders, immune responses, and cancer. The discovery of unique biogenesis pathways and subcellular localizations of lncRNAs has opened up potential therapeutic avenues for targeting lncRNAs in various biological and pathophysiological conditions.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2021)

添加到收藏夹

Article Cell Biology

TTN/OBSCN 'Double-Hit' predicts favourable prognosis, 'immune-hot' subtype and potentially better immunotherapeutic efficacy in colorectal cancer

Zaoqu Liu et al.

Summary: A recent study revealed that CRC patients with TTN/OBSCN 'Double-Hit' phenotype had significantly better prognosis, an 'immune-hot' subtype, and potentially better immunotherapeutic efficacy.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Cross-talk of four types of RNA modification writers defines tumor microenvironment and pharmacogenomic landscape in colorectal cancer

Huifang Chen et al.

Summary: Our study provides a comprehensive analysis of four RNA modifications in CRC and reveals the potential functions of these writers in TME, transcriptional and post-transcriptional events. The study also identifies the therapeutic implications of targeting these writers in cancer therapy, highlighting their potential clinical utility in targeted therapy and immunotherapy.

MOLECULAR CANCER (2021)

添加到收藏夹

Article Oncology

LINC01224 accelerates malignant transformation via MiR-193a-5p/CDK8 axis in gastric cancer

Hui Sun et al.

Summary: The study confirmed the impact of LINC01224 on the biological behavior of gastric cancer by mediating miR-193a-5p to regulate CDK8.

CANCER MEDICINE (2021)

添加到收藏夹

Article Oncology

The Identification and Validation of Two Heterogenous Subtypes and a Risk Signature Based on Ferroptosis in Hepatocellular Carcinoma

Zaoqu Liu et al.

Summary: Two heterogeneous ferroptosis subtypes with distinct metabolic and immune characteristics were identified in hepatocellular carcinoma. These subtypes showed differential sensitivity to immunotherapy and sorafenib. Additionally, a reliable risk signature for prognosis and immunotherapy assessment was developed.

FRONTIERS IN ONCOLOGY (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

GW4064 enhances the chemosensitivity of colorectal cancer to oxaliplatin by inducing pyroptosis

Jing Guo et al.

Summary: Long-term oxaliplatin therapy may lead to drug resistance and severe adverse events, limiting its clinical use. A combination of GW4064 and oxaliplatin showed synergistic effects in colon cancer cells, inhibiting cell growth and inducing cell death to slow tumor growth.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

An angiogenesis-related long noncoding RNA signature correlates with prognosis in patients with hepatocellular carcinoma

Dengliang Lei et al.

Summary: A 5-lncRNA signature was constructed to accurately predict the prognosis of HCC patients and showed good performance in evaluations. The signature can be used for diagnostic purposes with the inclusion of relevant clinical information when constructing the nomogram.

BIOSCIENCE REPORTS (2021)

添加到收藏夹

Article Cell Biology

A novel defined pyroptosis-related gene signature for predicting the prognosis of ovarian cancer

Ying Ye et al.

Summary: This study identified pyroptosis-related genes in ovarian cancer (OC) that may play important roles in tumor immunity and can be used to predict the prognosis of OCs. By dividing OC cases into subtypes based on the expression of these genes, different risk groups were identified with significant differences in survival possibilities. Additionally, immune-related genes were found to be enriched in high-risk groups, indicating a decreased immune status in these patients.

CELL DEATH DISCOVERY (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Identification of m6A methyltransferase-related lncRNA signature for predicting immunotherapy and prognosis in patients with hepatocellular carcinoma

Lili Li et al.

Summary: This study identified potential prognostic m6A methyltransferase-related lncRNAs for hepatocellular carcinoma (HCC) by analyzing gene expression data and different molecular markers. The research revealed that these lncRNAs were not only involved in immune-related biological processes and pathways, but also correlated with tumor microenvironment and expression of immune checkpoints.

BIOSCIENCE REPORTS (2021)

添加到收藏夹

Article Oncology

A novel signature constructed by ferroptosis-associated genes (FAGs) for the prediction of prognosis in bladder urothelial carcinoma (BLCA) and associated with immune infiltration

Jiao-chen Luan et al.

Summary: This study identified prognostic ferroptosis-associated genes in bladder urothelial carcinoma and established a novel gene signature that accurately predicts patient prognosis. The research also found significant differences in immune cell infiltration and immune-related pathways between two risk groups, providing new insights for bladder cancer treatment.

CANCER CELL INTERNATIONAL (2021)

添加到收藏夹

Review Immunology

NLRP3 inflammasome activation and cell death

Yi Huang et al.

Summary: The NLRP3 inflammasome is a cytosolic multiprotein complex that responds to microbial infection, endogenous danger signals, and environmental stimuli. Its activation can induce pyroptosis and release of inflammatory cytokines, contributing to innate immune defense. However, aberrant activation of the NLRP3 inflammasome is associated with inflammatory diseases, and there is a close relationship between cell death pathways and NLRP3 inflammasome activation.

CELLULAR & MOLECULAR IMMUNOLOGY (2021)

添加到收藏夹

Article Cell Biology

Caspase-3-mediated GSDME induced Pyroptosis in breast cancer cells through the ROS/JNK signalling pathway

Ziwen Zhang et al.

Summary: The study investigated the potential link between DOX-induced cell death and pyroptosis in two human breast cancer cell lines (MDA-MB-231 and T47D), confirming that DOX treatment reduced cell viability and induced pyroptosis morphology. Protein expression analyses highlighted GSDME as a key regulator in DOX-induced pyroptosis and emphasized the role of Caspase-3 activation. Furthermore, DOX treatments induced intracellular accumulation of ROS, JNK phosphorylation, and Caspase-3 activation.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)

添加到收藏夹

Review Oncology

Pyroptosis at the forefront of anticancer immunity

Reid Loveless et al.

Summary: Pyroptosis, a lytic and inflammatory programmed cell death pathway, has shown potential in addressing tumor resistance to apoptosis and the immunosuppressive tumor microenvironment by inducing a robust inflammatory response and marked tumor regression. Gasdermin proteins mediate pyroptosis and facilitate immune cell activation and infiltration, but aberrant pyroptosis may also contribute to tumor progression by upregulating gasdermin proteins in certain cancers. Harnessing pyroptosis as a tool in anticancer strategies shows promise in novel interventions.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2021)

添加到收藏夹

Article Oncology

Natural product triptolide induces GSDME-mediated pyroptosis in head and neck cancer through suppressing mitochondrial hexokinase-ΙΙ

Jing Cai et al.

Summary: The study reveals that triptolide eliminates head and neck cancer cells through inducing GSDME-mediated pyroptosis, and this effect is achieved by inhibiting HK-II and promoting caspase 3 activation. Combination with the SLC7A11 inhibitor erastin shows a strong synergistic effect in suppressing tumor survival in vitro and in a nude mice model. This research provides new insights into the use of TPL in cancer therapy.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

An NIR-Fluorophore-Based Theranostic for Selective Initiation of Tumor Pyroptosis-Induced Immunotherapy

Kewei Wang et al.

Summary: The near-infrared dye CyNH2 can selectively induce pyroptosis in cancer cells through NQO1 response, leading to systemic activation of antitumor immunity.

SMALL (2021)

添加到收藏夹

Article Oncology

Prognostic Signature of Hepatocellular Carcinoma and Analysis of Immune Infiltration Based on m6A-Related lncRNAs

Ting Guo et al.

Summary: By analyzing m6A-related lncRNAs, a signature was established to predict the prognosis of HCC patients, effectively distinguishing high-risk and low-risk groups, with differences observed in tumor immune infiltrating cells, immune checkpoint gene expression, and chemotherapy sensitivity.

FRONTIERS IN ONCOLOGY (2021)

添加到收藏夹

Article Oncology

Construction of an Immune-Related Six-lncRNA Signature to Predict the Outcomes, Immune Cell Infiltration, and Immunotherapy Response in Patients With Hepatocellular Carcinoma

Pengcheng Zhou et al.

Summary: This study identified a novel immune-related six-lncRNA signature that can stratify HCC patients into high-risk and low-risk groups with significantly different survival rates. The signature was confirmed to be an independent prognostic factor and was involved in immune-related biological processes and pathways, as well as immune cell infiltration. Moreover, it was associated with the expression of critical immune genes and could predict the clinical response to immunotherapy.

FRONTIERS IN ONCOLOGY (2021)

添加到收藏夹

Article Medicine, General & Internal

Increased morbidity and mortality of hepatocellular carcinoma patients in lower cost of living areas

Tomoki Sempokuya et al.

Summary: This study revealed racial and socioeconomic disparities among HCC patients in the United States, with lower COLI patients presenting with more advanced disease and higher COLI associated with improved median survival. Future research should further explore and address these differences.

WORLD JOURNAL OF CLINICAL CASES (2021)

添加到收藏夹

Article Cell Biology

The Pyroptosis-Related Signature Predicts Prognosis and Indicates Immune Microenvironment Infiltration in Gastric Cancer

Wei Shao et al.

Summary: This study classified gastric cancer patients based on pyroptosis-related regulators and developed a prognostic model called PS-score, which can predict patients' prognosis and overall survival time. Patients with a low PS-score have more inflammatory cell infiltration and better response to PD1/PD-L1 blockade immunotherapy.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

添加到收藏夹

Article Cell Biology

Long Non-coding RNA TMEM220-AS1 Suppressed Hepatocellular Carcinoma by Regulating the miR-484/MAGI1 Axis as a Competing Endogenous RNA

Cong Cao et al.

Summary: The study found that TMEM220-AS1 is significantly downregulated in HCC, promoting proliferation and metastasis of HCC cells through the miR-484/MAGI1 axis, demonstrating an important biological function.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

添加到收藏夹

Review Oncology

Pyroptosis, metabolism, and tumor immune microenvironment

Tiantian Du et al.

Summary: GSDM proteins play crucial roles in pyroptosis, and the impact of inflammatory characteristics induced by pyroptosis on the host depends on the context, timing, and response degree. Targeting pyroptosis may uncover potential therapeutic avenues in various metabolic diseases and the tumor microenvironment.

CLINICAL AND TRANSLATIONAL MEDICINE (2021)

添加到收藏夹

Review Medicine, Research & Experimental

Pyroptosis: A new frontier in cancer

Yuan Fang et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

Mechanism and regulation of pyroptosis-mediated in cancer cell death

Jianwei Ruan et al.

CHEMICO-BIOLOGICAL INTERACTIONS (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells

Zhiwei Zhou et al.

SCIENCE (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Gasdermin E suppresses tumour growth by activating anti-tumour immunity

Zhibin Zhang et al.

NATURE (2020)

添加到收藏夹

Article Cell Biology

LncRNA ADAMTS9-AS2 inhibits gastric cancer (GC) development and sensitizes chemoresistant GC cells to cisplatin by regulating miR-233-3p/NLRP3 axis

Niansheng Ren et al.

AGING-US (2020)

添加到收藏夹

Article Immunology

Identification of immune-related lncRNAs in periodontitis reveals regulation network of gene-lncRNA-pathway-immunocyte

Xiaoqi Zhang et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2020)

添加到收藏夹

Review Oncology

Ferroptosis, necroptosis, and pyroptosis in anticancer immunity

Rong Tang et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2020)

添加到收藏夹

Article Oncology

Long noncoding RNA ZFPM2-AS1 acts as a miRNA sponge and promotes cell invasion through regulation of miR-139/GDF10 in hepatocellular carcinoma

Hui He et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2020)

添加到收藏夹

Article Medicine, Research & Experimental

Immune-Related lncRNA to Construct Novel Signature and Predict the Immune Landscape of Human Hepatocellular Carcinoma

Weifeng Hong et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Four Immune-Related Long Non-coding RNAs for Prognosis Prediction in Patients With Hepatocellular Carcinoma

Muqi Li et al.

FRONTIERS IN MOLECULAR BIOSCIENCES (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

The functions of N6-methyladenosine modification in lncRNAs

Rong-Zhang He et al.

GENES & DISEASES (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

m6A RNA methylation-mediated HNF3γ reduction renders hepatocellular carcinoma dedifferentiation and sorafenib resistance

Tengfei Zhou et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

Adjuvant therapies after curative treatments for hepatocellular carcinoma: Current status and prospects

Xiao-Dong Zhu et al.

GENES & DISEASES (2020)

添加到收藏夹

Letter Biochemistry & Molecular Biology

GSDME enhances Cisplatin sensitivity to regress non-small cell lung carcinoma by mediating pyroptosis to trigger antitumor immunocyte infiltration

Zhouyangfan Peng et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

添加到收藏夹

Article Oncology

Long Noncoding RNA LUCAT1 Promotes Multiple Myeloma Cell Growth by Regulating the TGF-β Signaling Pathway

Zhaoyu Liu et al.

TECHNOLOGY IN CANCER RESEARCH & TREATMENT (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Chemotherapeutic paclitaxel and cisplatin differentially induce pyroptosis in A549 lung cancer cells via caspase-3/GSDME activation

Cheng-cheng Zhang et al.

APOPTOSIS (2019)

添加到收藏夹

Review Genetics & Heredity

Eukaryotic 5-methylcytosine (m5C) RNA Methyltransferases: Mechanisms, Cellular Functions, and Links to Disease

Katherine E. Bohnsack et al.

GENES (2019)

添加到收藏夹

Review Gastroenterology & Hepatology

A global view of hepatocellular carcinoma: trends, risk, prevention and management

Ju Dong Yang et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2019)

添加到收藏夹

Review Cell Biology

Reading, writing and erasing mRNA methylation

Sara Zaccara et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2019)

添加到收藏夹

Review Cell Biology

The role of pyroptosis in cancer: pro-cancer or pro-host?

Xiaojing Xia et al.

CELL DEATH & DISEASE (2019)

添加到收藏夹

Article Oncology

Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-Years for 29 Cancer Groups, 1990 to 2017 A Systematic Analysis for the Global Burden of Disease Study

Christina Fitzmaurice et al.

JAMA ONCOLOGY (2019)

添加到收藏夹

Article Cell Biology

Long non-coding RNA LUCAT1 promotes tumourigenesis by inhibiting ANXA2 phosphorylation in hepatocellular carcinoma

Yun Lou et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2019)

添加到收藏夹

Review Cell Biology

Reading, writing and erasing mRNA methylation

Sara Zaccara et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2019)

添加到收藏夹

Review Oncology

Diverging inflammasome signals in tumorigenesis and potential targeting

Rajendra Karki et al.

NATURE REVIEWS CANCER (2019)

添加到收藏夹

Article Chemistry, Analytical

Identification of YTH Domain-Containing Proteins as the Readers for N1-Methyladenosine in RNA

Xiaoxia Dai et al.

ANALYTICAL CHEMISTRY (2018)

添加到收藏夹

Article Immunology

The Immune Landscape of Cancer

Vesteinn Thorsson et al.

IMMUNITY (2018)

添加到收藏夹

Article Oncology

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Freddie Bray et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2018)

添加到收藏夹

Article Biochemistry & Molecular Biology

Signatures of T cell dysfunction and exclusion predict cancer immunotherapy response

Peng Jiang et al.

NATURE MEDICINE (2018)

添加到收藏夹

Article Multidisciplinary Sciences

The m1A landscape on cytosolic and mitochondrial mRNA at single-base resolution

Modi Safra et al.

NATURE (2017)

添加到收藏夹

Review Biochemistry & Molecular Biology

Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death

Jianjin Shi et al.

TRENDS IN BIOCHEMICAL SCIENCES (2017)

添加到收藏夹

Article Biology

Simultaneous enumeration of cancer and immune cell types from bulk tumor gene expression data

Julien Racle et al.

ELIFE (2017)

添加到收藏夹

Article Biotechnology & Applied Microbiology

xCell: digitally portraying the tissue cellular heterogeneity landscape

Dvir Aran et al.

GENOME BIOLOGY (2017)

添加到收藏夹

Article Cell Biology

5-methylcytosine promotes mRNA export-NSUN2 as the methyltransferase and ALYREF as an m5C reader

Xin Yang et al.

CELL RESEARCH (2017)

添加到收藏夹

Article Biochemistry & Molecular Biology

Molecular and Genetic Properties of Tumors Associated with Local Immune Cytolytic Activity

Michael S. Rooney et al.

CELL (2015)

添加到收藏夹

Review Biochemistry & Molecular Biology

Posttranscriptional Gene Regulation by Long Noncoding RNA

Je-Hyun Yoon et al.

JOURNAL OF MOLECULAR BIOLOGY (2013)

添加到收藏夹

Article Oncology

Global Cancer Statistics

Ahmedin Jemal et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2011)

添加到收藏夹

Article Multidisciplinary Sciences

Non-canonical inflammasome activation targets caspase-11

Nobuhiko Kayagaki et al.

NATURE (2011)

添加到收藏夹

Article Biochemistry & Molecular Biology

Functional demarcation of active and silent chromatin domains in human HOX loci by Noncoding RNAs

John L. Rinn et al.

CELL (2007)

添加到收藏夹

Review Cell Biology

Non-coding-RNA regulators of RNA polymerase II transcription

James A. Goodrich et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2006)

添加到收藏夹

Article Gastroenterology & Hepatology

PTK2 and EIF3S3 genes may be amplification targets at 8q23-q24 and are associated with large hepatocellular carcinomas

H Okamoto et al.

HEPATOLOGY (2003)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.