期刊
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
卷 10, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fcell.2022.886053
关键词
ocular lens; transforming growth factor beta; epithelial to mesenchymal transition; fibrosis; cell adhesion
资金
- Natural Sciences and Engineering Research Council of Canada (NSERC)
Injury to the ocular lens disrupts cell-cell and cell-capsule/basement membrane interactions, leading to a series of interconnected signaling events. These events include cell-adhesion and growth factor-mediated signaling pathways that play a crucial role in the induction and progression of epithelial-mesenchymal transition (EMT) and fibrosis of lens epithelial cells. The lens provides a simple and ideal system to study injury-induced signaling pathways associated with EMT and fibrosis.
Injury to the ocular lens perturbs cell-cell and cell-capsule/basement membrane interactions leading to a myriad of interconnected signaling events. These events include cell-adhesion and growth factor-mediated signaling pathways that can ultimately result in the induction and progression of epithelial-mesenchymal transition (EMT) of lens epithelial cells and fibrosis. Since the lens is avascular, consisting of a single layer of epithelial cells on its anterior surface and encased in a matrix rich capsule, it is one of the most simple and desired systems to investigate injury-induced signaling pathways that contribute to EMT and fibrosis. In this review, we will discuss the role of key cell-adhesion and mechanotransduction related signaling pathways that regulate EMT and fibrosis in the lens.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据