4.7 Article

Strategy for Scanning Peptide-Coding Circular RNAs in Colorectal Cancer Based on Bioinformatics Analysis and Experimental Assays

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

Review Biochemistry & Molecular Biology

Comprehensive landscape and future perspectives of circular RNAs in colorectal cancer

Fei Long et al.

Summary: Colorectal cancer involves abnormal expression of circRNAs, which act as oncogenes or tumor suppressors in regulating tumorigenesis, metastasis, and chemoradiation resistance. CircRNAs also serve as potential diagnostic and therapeutic targets in CRC.

MOLECULAR CANCER (2021)

Article Cell Biology

Circular RNA-encoded oncogenic E-cadherin variant promotes glioblastoma tumorigenicity through activation of EGFR-STAT3 signalling

Xinya Gao et al.

Summary: The activation of EGFR signalling in GBM is driven by a newly discovered secretory E-cadherin protein variant called C-E-Cad encoded by circular RNA. This mechanism promotes tumorigenicity in glioma stem cells and provides a promising approach for treating EGFR-driven GBM by enhancing the efficacy of anti-EGFR strategies.

NATURE CELL BIOLOGY (2021)

Article Biochemistry & Molecular Biology

A novel protein encoded by circMAPK1 inhibits progression of gastric cancer by suppressing activation of MAPK signaling

Tianlu Jiang et al.

Summary: The study identified that circMAPK1 is downregulated in gastric cancer tissues, and its lower expression predicts poor survival. CircMAPK1 exerts a tumor suppressive effect through the encoded protein MAPK1-109aa, inhibiting the proliferation and invasion of gastric cancer cells.

MOLECULAR CANCER (2021)

Article Biotechnology & Applied Microbiology

Exosomal miR-208b related with oxaliplatin resistance promotes Treg expansion in colorectal cancer

Tao Ning et al.

Summary: Our study demonstrates that miR-208b may serve as a non-invasive marker for predicting the sensitivity of CRC patients to FOLFOX chemotherapy. Colon cancer cell-secreted miR-208b promotes Treg expansion by targeting PDCD4, leading to tumor growth and oxaliplatin resistance.

MOLECULAR THERAPY (2021)

Article Chemistry, Multidisciplinary

HNRNPL Circularizes ARHGAP35 to Produce an Oncogenic Protein

Yan Li et al.

Summary: This study identified a novel oncogenic circRNA called circARHGAP35 originating from the tumor suppressor gene ARHGAP35, which has antithetical expression and functions with linear ARHGAP35. CircARHGAP35 encodes a truncated protein without the Rho GAP domain, promoting cancer cell progression by interacting with TFII-I protein in the nucleus. HNRNPL facilitates the formation of circARHGAP35, which is associated with poor survival in cancer patients.

ADVANCED SCIENCE (2021)

Article Biotechnology & Applied Microbiology

A novel protein encoded by circular SMO RNA is essential for Hedgehog signaling activation and glioblastoma tumorigenicity

Xujia Wu et al.

Summary: This study identifies SMO-193a.a. encoded by circ-SMO as a critical component for Hedgehog signaling activation in glioblastoma, playing a key role in tumorigenesis. The positive feedback loop involving Shh/Gli1/FUS/SMO-193a.a. sustains Hedgehog signaling in glioblastoma, with higher expression of SMO-193a.a. predicting worse overall survival in patients, highlighting its potential prognostic value.

GENOME BIOLOGY (2021)

Article Medicine, Research & Experimental

CXCL12-mediated HOXB5 overexpression facilitates Colorectal Cancer metastasis through transactivating CXCR4 and ITGB3

Weibo Feng et al.

Summary: HOXB5 gene plays a crucial role in promoting colorectal cancer metastasis by transactivating metastatic related genes CXCR4 and ITGB3. Additionally, a positive feedback loop of CXCL12-HOXB5-CXCR4 has been identified to have an important role in colorectal cancer metastasis.

THERANOSTICS (2021)

Article Oncology

Colorectal cancer statistics, 2020

Rebecca L. Siegel et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2020)

Article Biochemistry & Molecular Biology

CircPTK2 (hsa_circ_0005273) as a novel therapeutic target for metastatic colorectal cancer

Hongbao Yang et al.

MOLECULAR CANCER (2020)

Article Biotechnology & Applied Microbiology

circCAMSAP1 Promotes Tumor Growth in Colorectal Cancer via the miR-328-5p/E2F1 Axis

Chi Zhou et al.

MOLECULAR THERAPY (2020)

Article Medicine, Research & Experimental

Circ_cse1l Inhibits Colorectal Cancer Proliferation by Binding to eIF4A3

Bin Xu et al.

MEDICAL SCIENCE MONITOR (2020)

Review Oncology

Circular RNAs: A New Piece in the Colorectal Cancer Puzzle

Pinelopi I. Artemaki et al.

CANCERS (2020)

Article Biochemistry & Molecular Biology

The Translational Landscape of the Human Heart

Sebastiaan van Heesch et al.

Article Multidisciplinary Sciences

A universal approach to investigate circRNA protein coding function

Dingding Mo et al.

SCIENTIFIC REPORTS (2019)

Article Biotechnology & Applied Microbiology

Translation of the circular RNA circ-catenin promotes liver cancer cell growth through activation of the Wnt pathway

Wei-Cheng Liang et al.

GENOME BIOLOGY (2019)

Article Oncology

Novel Role of FBXW7 Circular RNA in Repressing Glioma Tumorigenesis

Yibing Yang et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2018)

Article Oncology

Novel Role of FBXW7 Circular RNA in Repressing Glioma Tumorigenesis

Yibing Yang et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2018)

Article Biochemistry & Molecular Biology

A novel protein encoded by the circular form of the SHPRH gene suppresses glioma tumorigenesis

Maolei Zhang et al.

ONCOGENE (2018)

Article Cell Biology

CircHIPK3 promotes colorectal cancer growth and metastasis by sponging miR-7

Kaixuan Zeng et al.

CELL DEATH & DISEASE (2018)

Article Biochemistry & Molecular Biology

Translation of CircRNAs

Nagarjuna Reddy Pamudurti et al.

MOLECULAR CELL (2017)

Article Biochemistry & Molecular Biology

Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis

Ivano Legnini et al.

MOLECULAR CELL (2017)

Article Cell Biology

Extensive translation of circular RNAs driven by N6-methyladenosine

Yun Yang et al.

CELL RESEARCH (2017)

Article Multidisciplinary Sciences

Rolling Circle Translation of Circular RNA in Living Human Cells

Naoko Abe et al.

SCIENTIFIC REPORTS (2015)