4.7 Review

Role of the Mosaic Cisternal Maturation Machinery in Glycan Synthesis and Oncogenesis

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Cell Biology

Clathrin adaptors mediate two sequential pathways of intra-Golgi recycling

Jason C. Casler et al.

Summary: Through studying yeast, it was found that the AP-1 and Ent5 clathrin adaptors cooperate in the recycling of Golgi transmembrane proteins. Removal of these proteins leads to the diversion of Golgi proteins into an alternative recycling loop involving traffic to the plasma membrane and endocytosis.

JOURNAL OF CELL BIOLOGY (2021)

Article Biology

Src activates retrograde membrane traffic through phosphorylation of GBF1

Joanne Chia et al.

Summary: The Src tyrosine kinase promotes the relocation of GALNTs enzymes by phosphorylating GBF1, inducing tubular transport carriers formation. This mechanism of tyrosine phosphorylation-mediated regulation may be a conserved and widespread mechanism in GEF-Arf complexes.
Article Biology

Golgi membrane protein Erd1 Is essential for recycling a subset of Golgi glycosyltransferases

Richa Sardana et al.

Summary: This study uncovers the role of an integral membrane protein Erd1 in facilitating Golgi glycosyltransferase recycling in yeast, and loss of Erd1 function leads to mislocalization of Golgi enzymes. Evidence suggests that Erd1 is essential for productive recycling of early Golgi enzymes, and provides new insights on how the localization of Golgi glycosyltransferases is spatially and temporally regulated.
Article Biochemistry & Molecular Biology

Golgi maturation-dependent glycoenzyme recycling controls glycosphingolipid biosynthesis and cell growth via GOLPH3

Riccardo Rizzo et al.

Summary: Research shows that a group of sequentially-acting enzymes in the Golgi bind to the oncogenic protein GOLPH3, affecting glycosphingolipid synthesis and cell proliferation by regulating enzyme localization and degradation rate. These findings reveal a novel oncogenic mechanism of action for GOLPH3 in glycosphingolipid metabolism.

EMBO JOURNAL (2021)

Article Biochemistry & Molecular Biology

ST6Gal1 targets the ectodomain of ErbB2 in a site-specific manner and regulates gastric cancer cell sensitivity to trastuzumab

Henrique O. Duarte et al.

Summary: The resistance of ErbB2-positive gastric cancer cells to trastuzumab is actively modulated by ST6Gal1-mediated aberrant alpha 2,6-sialylation, which reshapes the glycomes and sensitizes the cells to trastuzumab-induced cytotoxicity.

ONCOGENE (2021)

Review Biochemistry & Molecular Biology

Courier service for phosphatidylinositol: PITPs deliver on demand

Tim G. Ashlin et al.

Summary: The article discusses the role of phosphatidylinositol transfer proteins (PITPs) in mobilising PI from the ER to provide substrate for resident kinases for phosphorylation. Recent studies have identified specific and overlapping functions for the three soluble PITPs (PITP alpha, PITP beta and PITPNC1) in phospholipase C signalling, neuronal function, membrane trafficking, viral replication, and cancer metastases.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2021)

Article Biochemistry & Molecular Biology

GRASP55 regulates intra-Golgi localization of glycosylation enzymes to control glycosphingolipid biosynthesis

Prathyush Pothukuchi et al.

Summary: The Golgi matrix protein GRASP55 plays a crucial role in regulating the compartmentalized localization of key enzymes involved in glycosphingolipid biosynthesis. Lack of GRASP55 or expression of mutant enzymes without GRASP55 binding sites can affect the synthesis of glycosphingolipids by altering metabolic flux.

EMBO JOURNAL (2021)

Article Cell Biology

GOLPH3 and GOLPH3L are broad-spectrum COPI adaptors for sorting into intra-Golgi transport vesicles

Lawrence G. Welch et al.

Summary: The fidelity of Golgi glycosylation is partly maintained by the compartmentalization of enzymes within the stack and binding of the COPI adaptor GOLPH3+3L to the cytoplasmic tails of Golgi enzymes. These proteins play important roles in diverse glycosylation pathways in the Golgi and their deletion leads to multiple defects in glycosylation.

JOURNAL OF CELL BIOLOGY (2021)

Article Cell Biology

A quantitative study of the Golgi retention of glycosyltransferases

Xiuping Sun et al.

Summary: The mechanism of Golgi localization of Golgi glycosyltransferases has been found to be primarily through retention rather than retrieval. The study also revealed the contributions of different regions of ST6GAL1 to Golgi retention, showing that the N-terminal cytosolic tail and transmembrane domain can act as Golgi export signals.

JOURNAL OF CELL SCIENCE (2021)

Article Multidisciplinary Sciences

Addiction to Golgi-resident PI4P synthesis in chromosome 1q21.3-amplified lung adenocarcinoma cells

Lei Shi et al.

Summary: The study reveals that amplification of chromosome 1q21.3 region leads to the encoding of phosphatidylinositol (PI)-4 kinase III8 (PI4KIII8), which is crucial for Golgi-resident PI-4-phosphate (PI4P) synthesis, cell survival, and effector protein secretion. Lung adenocarcinoma cells with 1q amplification develop tolerance to PI4KIII8 antagonist treatment by activating an miR-218-5p-dependent competing endogenous RNA network that up-regulates PI4KII alpha, maintaining cell viability and protein secretion.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

Review Cell Biology

Extensive GTPase crosstalk regulates Golgi trafficking and maturation

Laura L. Thomas et al.

CURRENT OPINION IN CELL BIOLOGY (2020)

Article Cell Biology

The function of GORASPs in Golgi apparatus organization in vivo

Rianne Grond et al.

JOURNAL OF CELL BIOLOGY (2020)

Article Cell Biology

Vesicular and uncoated Rab1-dependent cargo carriers facilitate ER to Golgi transport

Laura M. Westrate et al.

JOURNAL OF CELL SCIENCE (2020)

Article Multidisciplinary Sciences

Human Golgi phosphoprotein 3 is an effector of RAB1A and RAB1B

Viviana A. Cavieres et al.

PLOS ONE (2020)

Review Cell Biology

Global view of human protein glycosylation pathways and functions

Katrine T. Schjoldager et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)

Review Oncology

New era of research on cancer-associated glycosphingolipids

Koichi Furukawa et al.

CANCER SCIENCE (2019)

Article Multidisciplinary Sciences

The GalNAc-T Activation (GALA) Pathway: Drivers and markers

Joanne Chia et al.

PLOS ONE (2019)

Article Biochemistry & Molecular Biology

Yeast Dop1 is required for glycosyltransferase retrieval from the trans-Golgi network

Shen-Bao Zhao et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2019)

Review Biochemistry & Molecular Biology

Translation of genome to glycome: role of the Golgi apparatus

Prathyush Pothukuchi et al.

FEBS LETTERS (2019)

Article Biochemistry & Molecular Biology

An Atlas of Human Glycosylation Pathways Enables Display of the Human Glycome by Gene Engineered Cells

Yoshiki Narimatsu et al.

MOLECULAR CELL (2019)

Review Biochemistry & Molecular Biology

Emerging structural insights into glycosyltransferase-mediated synthesis of glycans

Kelley W. Moremen et al.

NATURE CHEMICAL BIOLOGY (2019)

Article Multidisciplinary Sciences

Expression analysis and implication of Rab1A in gastrointestinal relevant tumor

Menglin Xu et al.

SCIENTIFIC REPORTS (2019)

Article Multidisciplinary Sciences

GORAB scaffolds COPI at the trans-Golgi for efficient enzyme recycling and correct protein glycosylation

Tomasz M. Witkos et al.

NATURE COMMUNICATIONS (2019)

Article Multidisciplinary Sciences

A CRISPR Screen Identifies LAPTM4A and TM9SF Proteins as Glycolipid-Regulating Factors

Toshiyuki Yamaji et al.

ISCIENCE (2019)

Article Multidisciplinary Sciences

Recycling of Golgi glycosyltransferases requires direct binding to coatomer

Lin Liu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Article Biochemistry & Molecular Biology

Glycosphingolipid metabolic reprogramming drives neural differentiation

Domenico Russo et al.

EMBO JOURNAL (2018)

Review Biochemistry & Molecular Biology

Biological roles of glycans

Ajit Varki

GLYCOBIOLOGY (2017)

Article Anatomy & Morphology

GOLPH3 and oncogenesis: What is the molecular link?

Riccardo Rizzo et al.

TISSUE & CELL (2017)

Article Cell Biology

Regulation of Golgi Cisternal Progression by Ypt/Rab GTPases

Jane J. Kim et al.

DEVELOPMENTAL CELL (2016)

Review Biochemistry & Molecular Biology

Glycosphingolipid-Protein Interaction in Signal Transduction

Domenico Russo et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2016)

Review Neurosciences

The GOLPH3 pathway regulates Golgi shape and function and is activated by DNA damage

Matthew D. Buschman et al.

FRONTIERS IN NEUROSCIENCE (2015)

Review Oncology

Glycosylation in cancer: mechanisms and clinical implications

Salome S. Pinho et al.

NATURE REVIEWS CANCER (2015)

Article Oncology

Rab1A Is an mTORC1 Activator and a Colorectal Oncogene

Janice D. Thomas et al.

CANCER CELL (2014)

Article Biochemistry & Molecular Biology

DNA Damage Triggers Golgi Dispersal via DNA-PK and GOLPH3

Suzette E. Farber-Katz et al.

Review Pathology

Cellular Heterogeneity and Molecular Evolution in Cancer

Vanessa Almendro et al.

ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 8 (2013)

Article Biochemistry & Molecular Biology

Recruitment of arfaptins to the trans-Golgi network by PI(4)P and their involvement in cargo export

David Cruz-Garcia et al.

EMBO JOURNAL (2013)

Review Cell Biology

A three-stage model of Golgi structure and function

Kasey J. Day et al.

HISTOCHEMISTRY AND CELL BIOLOGY (2013)

Article Biochemistry & Molecular Biology

Functional roles of glycogene and N-glycan in multidrug resistance of human breast cancer cells

Hongye Ma et al.

IUBMB LIFE (2013)

Article Cell Biology

GOLPH3L antagonizes GOLPH3 to determine Golgi morphology

Michelle M. Ng et al.

MOLECULAR BIOLOGY OF THE CELL (2013)

Article Biochemistry & Molecular Biology

Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal

Jianjiong Gao et al.

SCIENCE SIGNALING (2013)

Article Multidisciplinary Sciences

Molecular recognition of a single sphingolipid species by a protein's transmembrane domain

F. -Xabier Contreras et al.

NATURE (2012)

Article Multidisciplinary Sciences

The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups

Christina Curtis et al.

NATURE (2012)

Review Biochemistry & Molecular Biology

Hallmarks of Cancer: The Next Generation

Douglas Hanahan et al.

Article Cell Biology

Golgi Glycosylation

Pamela Stanley

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2011)

Article Cell Biology

Membrane Organization and Lipid Rafts

Kai Simons et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2011)

Article Cell Biology

Regulation of O-glycosylation through Golgi-to-ER relocation of initiation enzymes

David J. Gill et al.

JOURNAL OF CELL BIOLOGY (2010)

Article Biochemistry & Molecular Biology

Circos: An information aesthetic for comparative genomics

Martin Krzywinski et al.

GENOME RESEARCH (2009)

Article Cell Biology

PtdIns4P recognition by Vps74/GOLPH3 links PtdIns 4-kinase signaling to retrograde Golgi trafficking

Christopher S. Wood et al.

JOURNAL OF CELL BIOLOGY (2009)

Article Multidisciplinary Sciences

GOLPH3 modulates mTOR signalling and rapamycin sensitivity in cancer

Kenneth L. Scott et al.

NATURE (2009)

Review Biotechnology & Applied Microbiology

Cell cycle kinases as therapeutic targets for cancer

Silvia Lapenna et al.

NATURE REVIEWS DRUG DISCOVERY (2009)

Article Multidisciplinary Sciences

Signal-mediated dynamic retention of glycosyltransferases in the Golgi

Linna Tu et al.

SCIENCE (2008)

Article Cell Biology

Rab1b interacts with GBF1 and modulates both ARR dynamics and COPI association

Pablo Monetta et al.

MOLECULAR BIOLOGY OF THE CELL (2007)

Article Multidisciplinary Sciences

Structure-based discovery of an inhibitor of Arf activation by Sec7 domains through targeting of protein-protein complexes

Julien Viaud et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Review Biochemistry & Molecular Biology

Lipid-transfer proteins in membrane trafficking at the Golgi complex

Maria Antonietta De Matteis et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2007)

Article Multidisciplinary Sciences

Differential localization of coatomer complex isoforms within the Golgi apparatus

Joerg Moelleken et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Article Multidisciplinary Sciences

Live imaging of yeast Golgi cisternal maturation

Kumi Matsuura-Tokita et al.

NATURE (2006)

Review Cell Biology

ARF proteins: roles in membrane traffic and beyond

C D'Souza-Schorey et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2006)

Article Multidisciplinary Sciences

The glycosphingolipid globotriaosylceramide in the metastatic transformation of colon cancer

O Kovbasnjuk et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Cell Biology

COPI recruitment is modulated by a Rab1b-dependent mechanism

C Alvarez et al.

MOLECULAR BIOLOGY OF THE CELL (2003)

Review Oncology

Dissemination and growth of cancer cells in metastatic sites

AF Chambers et al.

NATURE REVIEWS CANCER (2002)

Review Cell Biology

Turning on ARF: the Sec7 family of guanine-nucleotide-exchange factors

CL Jackson et al.

TRENDS IN CELL BIOLOGY (2000)

Article Multidisciplinary Sciences

The putative tumor suppressors EXT1 and EXT2 form a stable complex that accumulates in the Golgi apparatus and catalyzes the synthesis of heparan sulfate

C McCormick et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)