期刊
PHOTOACOUSTICS
卷 25, 期 -, 页码 -出版社
ELSEVIER GMBH
DOI: 10.1016/j.pacs.2021.100323
关键词
Photoacoustic imaging; Fluorescence imaging; Endoscopy; Multimode fibre; Multi-modal imaging
类别
资金
- Academy of Medical Sciences/the Wellcome Trust/the Government Department of Business, Energy and Industrial Strategy/the British Heart Foundation/Diabetes UK Springboard Award [SBF006/1136]
- Wellcome Trust, United Kingdom [203148/Z/16/Z, WT101957]
- Engineering and Physical Sciences Research Council, United Kingdom [NS/A000027/1, NS/A000049/1]
- Wellcome Trust [203148/Z/16/Z] Funding Source: Wellcome Trust
Multimode fibres (MMFs) are gaining attention in optical endoscopy due to their potential for miniaturization, improved spatial resolution, and cost-effectiveness. Researchers have developed a video-rate dual-modal photoacoustic (PA) and fluorescence microscopy probe using a high-speed digital micromirror device (DMD) for forward-viewing endomicroscopy. The probe achieved high-speed imaging with adjustable PA imaging speed and spatial resolution, and demonstrated the capability of dual-modal imaging.
Multimode fibres (MMFs) are becoming increasingly attractive in optical endoscopy as they promise to enable unparallelled miniaturisation, spatial resolution and cost. However, high-speed imaging with wavefront shaping has been challenging. Here, we report the development of a video-rate dual-modal photoacoustic (PA) and fluorescence microscopy probe with a high-speed digital micromirror device (DMD) towards forward-viewing endomicroscopy. Optimal DMD patterns were obtained using a real-valued intensity transmission matrix algorithm to raster-scan a 1.5 mu m-diameter focused beam at the distal fibre tip for imaging. The PA imaging speed and spatial resolution were varied from similar to 2 to 57 frames per second and from 1.7 to 3 mu m, respectively. Further, high-fidelity PA images of carbon fibres and mouse red blood cells were acquired at unprecedented speed. The capability of dual-modal imaging was demonstrated with phantoms. We anticipate that with further miniaturisation of the ultrasound detector, this probe could be integrated into medical needles to guide minimally invasive procedures.
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