期刊
GUT MICROBES
卷 14, 期 1, 页码 -出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/19490976.2022.2055943
关键词
Enterotoxigenic Escherichia coli; gut microbiota; pathogenesis; enterotoxin; colonization resistance
资金
- National Natural Science Foundation of China [31930106, 31829004, 31722054]
- National Ten-thousand Talents Program of China [23070201]
- Henan Province Public Benefit Research Foundation [201300111200-05]
- 2115 Talent Development Program of China Agricultural University [1041-00109019]
- Henan Wofengde Biological Technology Co., Ltd. [201905410411435]
- 111 Project [B16044]
This review focuses on recent discoveries about the etiology, pathogenesis, and clinical manifestation of enterotoxigenic Escherichia coli (ETEC), as well as the colonization resistances mediated by gut microbiota and preventative strategies against ETEC.
Enterotoxigenic Escherichia coli (ETEC) is a major cause of diarrhea in children and travelers in developing countries. ETEC is characterized by the ability to produce major virulence factors including colonization factors (CFs) and enterotoxins, that bind to specific receptors on epithelial cells and induce diarrhea. The gut microbiota is a stable and sophisticated ecosystem that performs a range of beneficial functions for the host, including protection against pathogen colonization. Understanding the pathogenic mechanisms of ETEC and the interaction between the gut microbiota and ETEC represents not only a research need but also an opportunity and challenge to develop precautions for ETEC infection. Herein, this review focuses on recent discoveries about ETEC etiology, pathogenesis and clinical manifestation, and discusses the colonization resistances mediated by gut microbiota, as well as preventative strategies against ETEC with an aim to provide novel insights that can reduce the adverse effect on human health.
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