3D printing of customized key biomaterials genomics for bone regeneration

The rapid development of regenerative medicine has brought new opportunities for disease treatment. However, the clinically adopted approaches are full of technical and translational barriers. At present, the selection and screening efficiency of key material factors in regenerative medicine, such as material category, structure, and performance, is relatively low. The screening process costs a large quantity of materials, manpower, time, and money. The key material factors of bone regeneration include the materials' composition, structure, surface morphology, additives, and so on. They resemble genes in organisms that determine the biological function of cells. The design and screening of biomaterials genomics are crucial for bone tissue engineering scaffolds to achieve osteoinduction and osteoconduction. In this study, we provided a bone regeneration test chip fabricated by digital light projection for high-throughput screening of the biomaterials genomics for bone regeneration. The bone test chip contains various test units that form two channels: one for screening the osteoconduction biofunctions and the other for screening the osteoinduction. It effectively realizes the high-throughput screening of specific biological functions in regenerative medicine.(c) 2021 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license ( http://creativecommons.org/licenses/by-nc-nd/4.0/ )

Automated summary

The rapid development of regenerative medicine has provided new opportunities for disease treatment, but faces technical and translational barriers in clinically adopted approaches. The selection and screening efficiency of key material factors are relatively low, and the design and screening of biomaterials genomics are crucial for achieving osteoinduction and osteoconduction. The bone regeneration test chip fabricated by digital light projection enables high-throughput screening of specific biological functions in regenerative medicine.