期刊
APPLIED MATERIALS TODAY
卷 26, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.apmt.2021.101310
关键词
Chitooligosaccharides; Europium; pH sensitivity; Inflammation; Vascularization; Wound healing
资金
- National Natural Science Foundation of China [31872758]
- National Key R&D Program of China [2018YFC0311103]
- Natural Science Foundation of Guangdong Province, China [2021A1515011093]
This study proposes a method using a complex of chitooligosaccharides and europium ions to monitor wound healing, modulate inflammation, and promote vascularization in pressure ulcer injuries. The complex not only monitors wound healing through fluorescence changes, but also demonstrates anti-inflammatory activity and promotes vascularization. The simple construction enables visual monitoring and multi-stage adaptive wound repair.
Ischaemia and inflammation can hinder the wound healing process in pressure ulcer (PU) injuries. Direct monitoring of the healing status and multi-stage adaptive repair have not been realised in the PU treatment. This study proposes a method to monitor the status of wound healing, while being able to modulate the inflammation and promote vascularization for effective healing of PU injuries, using a complex of chitooligosaccharides (COS) and europium ions (Eu3+). The COS-Eu complex was prepared via one-pot coordination, and its morphology, structure, physicochemical, and fluorescence properties were studied. The results indicate that the COS-Eu complex not only monitors wound healing through fluorescence changes, but also modulates inflammation and promotes vascularization, which were verified both in vitro and in vivo. Noticeably, the COS-Eu complex could shift M1 macrophages to M2 macrophages, demonstrating anti-inflammatory activity. Furthermore, it played a synergistic role with Eu to promote vascularization and tissue regeneration. This simple construction of COS-Eu complex enabled visual monitoring and multi-stage adaptive wound repair, providing a comprehensive solution for PU injury with integrated treatment and monitoring throughout the healing process. (C) 2021 Elsevier Ltd. All rights reserved.
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