Severe acute hepatitis in children: investigate SARS-CoV-2 superantigens

Review Immunology

SARS-CoV-2 infections in children: Understanding diverse outcomes

Petter Brodin

Summary: SARS-CoV-2 infections in children usually result in mild or asymptomatic infections, and the reasons behind this are not fully understood. Possible explanations include more efficient local tissue responses, better thymic function, and crossreactive immunity. Post-infectious hyperinflammatory syndromes are rare in children and young people, but very rarely seen in adults. This article offers an additional explanation to mild infections, viral dynamics, and the higher incidence of rare multisystem inflammatory syndromes in children and young people from a life history and energy allocation perspective.

IMMUNITY (2022)

添加到收藏夹

Article Medicine, Research & Experimental

Multisystem inflammatory syndrome in children is driven by zonulin-dependent loss of gut mucosal barrier

Lael M. Yonker et al.

Summary: In children with MIS-C, prolonged presence of SARS-CoV-2 in the GI tract led to the release of zonulin, a biomarker of intestinal permeability, and subsequent trafficking of SARS-CoV-2 antigens into the bloodstream, resulting in hyperinflammation. Treatment with larazotide, a zonulin antagonist, reduced plasma SARS-CoV-2 spike antigen levels and inflammatory markers in a patient with MIS-C, leading to clinical improvement beyond current available treatments. These mechanistic insights provide potential targets for diagnosing, treating, and preventing MIS-C in children.

JOURNAL OF CLINICAL INVESTIGATION (2021)

添加到收藏夹

Article Medicine, Research & Experimental

HLA class I-associated expansion of TRBV11-2 T cells in multisystem inflammatory syndrome in children

Rebecca A. Porritt et al.

Summary: Our study found a significant expansion of TCR beta variable gene 11-2 (TRBV11-2) in MIS-C patients, with extensive junctional diversity observed in the expanded TRBV11-2 clones. This expansion was correlated with the severity of MIS-C and serum cytokine levels, suggesting a novel mechanism of T cell expansion independent of CDR3. Additionally, in silico modeling indicated a potential interaction between the V beta chain encoded by TRBV11-2 and the superantigen-like motif of SARS-CoV-2 spike glycoprotein, possibly mediating T cell expansion and activation in MIS-C patients.

JOURNAL OF CLINICAL INVESTIGATION (2021)

添加到收藏夹

Article Gastroenterology & Hepatology

Acute Hepatitis Is a Prominent Presentation of the Multisystem Inflammatory Syndrome in Children: A Single-Center Report

Amanda Cantor et al.

HEPATOLOGY (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Superantigenic character of an insert unique to SARS-CoV-2 spike supported by skewed TCR repertoire in patients with hyperinflammation

Mary Hongying Cheng et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

添加到收藏夹

Article Immunology

Increased sensitivity to staphylococcal enterotoxin B following adenoviral infection

TO Yarovinsky et al.

INFECTION AND IMMUNITY (2005)

添加到收藏夹

Severe acute hepatitis in children: investigate SARS-CoV-2 superantigens

相关参考文献

SARS-CoV-2 infections in children: Understanding diverse outcomes

Multisystem inflammatory syndrome in children is driven by zonulin-dependent loss of gut mucosal barrier

HLA class I-associated expansion of TRBV11-2 T cells in multisystem inflammatory syndrome in children

Acute Hepatitis Is a Prominent Presentation of the Multisystem Inflammatory Syndrome in Children: A Single-Center Report

Superantigenic character of an insert unique to SARS-CoV-2 spike supported by skewed TCR repertoire in patients with hyperinflammation

Increased sensitivity to staphylococcal enterotoxin B following adenoviral infection

导出引文

分享论文