☆ 4.5 Editorial Material

Adapting to vaccination

NATURE ECOLOGY & EVOLUTION (2022)

Antigenic escape selects for the evolution of higher pathogen transmission and virulence

Akira Sasaki et al.

Summary: The study explores the impact of antigenic drift and escape on virulence evolution in pathogens, showing that non-equilibrium dynamics favor the persistence of more virulent pathogens. The research predicts antigenic shifts, increased variation, and differences in virulence among related pathogens, with implications for epidemic behavior and control strategies. The findings emphasize the importance of considering the evolutionary consequences of non-equilibrium dynamics.

NATURE ECOLOGY & EVOLUTION (2022)

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Article Ecology

Effects of epistasis and recombination between vaccine-escape and virulence alleles on the dynamics of pathogen adaptation

David McLeod et al.

Summary: This study investigates the joint evolution mechanism of pathogen adaptation to vaccine-induced immune response and pathogen virulence, with a focus on the protective effects of vaccines. The research reveals that vaccines that block infection, reduce transmission, and/or increase clearance generate positive epistasis between vaccine-escape and virulence alleles, while vaccines that reduce mortality generate negative epistasis. High rates of recombination can also affect these predictions.

NATURE ECOLOGY & EVOLUTION (2022)

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Article Medicine, General & Internal