4.8 Article

PD-1 Blunts the Function of Ovarian Tumor-Infiltrating Dendritic Cells by Inactivating NF-κB

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CANCER RESEARCH
卷 76, 期 2, 页码 239-250

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AMER ASSOC CANCER RESEARCH
DOI: 10.1158/0008-5472.CAN-15-0748

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  1. Minnesota Ovarian Cancer Alliance
  2. Fred C. and Katherine B. Andersen Foundation
  3. Marsha Rivkin Center for Ovarian Cancer Research
  4. Mayo Clinic Ovarian Cancer SPORE [P50-CA136393]
  5. Mayo Clinic Cancer Center Support Grant [P30-CA015083-25]

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The PD-1:PD-L1 immune signaling axis mediates suppression of T-cell-dependent tumor immunity. PD-1 expression was recently found to be upregulated on tumor-infiltrating murine (CD11c(+)CD11b(+)CD8(-)CD209a(+)) and human (CD1c(+)CD19(-)) myeloid dendritic cells (TIDC), an innate immune cell type also implicated in immune escape. However, there is little knowledge concerning how PD-1 regulates innate immune cells. In this study, we examined the role of PD-1 in TIDCs derived from mice bearing ovarian tumors. Similar to lymphocytes, TIDC expression of PD-1 was associated with expression of the adapter protein SHP-2, which signals to NF-kappa B; however, in contrast to its role in lymphocytes, we found that expression of PD-1 in TIDC tonically paralyzed NF-kappa B activation. Further mechanistic investigations showed that PD-1 blocked NF-kappa B-dependent cytokine release in a SHP-2-dependent manner. Conversely, inhibition of NF-kappa B-mediated antigen presentation by PD-1 occurred independently of SHP-2. Collectively, our findings revealed that PD-1 acts in a distinct manner in innate immune cells compared with adaptive immune cells, prompting further investigations of the signaling pathways controlled by this central mediator of immune escape in cancer. (C) 2015 AACR.

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