4.3 Review

The role of mineralocorticoid receptor activation in kidney inflammation and fibrosis

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Urology & Nephrology

Nonepithelial mineralocorticoid receptor activation as a determinant of kidney disease

Toshifumi Nakamura et al.

Kidney International Supplements (2022)

Article Medicine, General & Internal

Testing for Primary Aldosteronism and Mineralocorticoid Receptor Antagonist Use Among US Veterans A Retrospective Cohort Study

Jordana B. Cohen et al.

Summary: The study found that testing rates for primary aldosteronism were low among U.S. Veterans, but those who were tested were more likely to receive evidence-based treatment and achieve better blood pressure control over time.

ANNALS OF INTERNAL MEDICINE (2021)

Article Endocrinology & Metabolism

Linking Kidney and Cardiovascular Complications in Diabetes-Impact on Prognostication and Treatment: The 2019 Edwin Bierman Award Lecture

Peter Rossing et al.

Summary: In diabetes, chronic kidney disease is characterized by increased albuminuria and decreased glomerular filtration rate, leading to higher risks of cardiovascular events, mortality, and end-stage kidney disease. Recent years have seen the emergence of promising treatments like sodium-glucose cotransporter 2 inhibitors and glucagon-like peptide 1 agonists, offering potential for personalized treatment approaches based on individual physiological pathways.

DIABETES (2021)

Article Urology & Nephrology

Deletion of Myeloid Interferon Regulatory Factor 4 (Irf4) in Mouse Model Protects against Kidney Fibrosis after Ischemic Injury by Decreased Macrophage Recruitment and Activation

Kensuke Sasaki et al.

Summary: Deletion of Irf4 from myeloid cells reduces renal fibrosis and activation of macrophages after severe AKI, primarily through inhibiting PI3 kinase/AKT pathway and monocyte recruitment. These findings provide new insights into the role of IRF4 in regulating kidney injury recovery.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2021)

Article Urology & Nephrology

Stabilization of hypoxia-inducible factor ameliorates glomerular injury sensitization after tubulointerstitial injury

Jun Zou et al.

Summary: The study found that stabilizing hypoxia-inducible factor-alpha (HIF-alpha) can ameliorate tubulointerstitial injury and reduce its impact on subsequent glomerular injury. Restoring HIFs may blunt the adverse crosstalk between tubular injury and glomerular injury.

KIDNEY INTERNATIONAL (2021)

Article Cardiac & Cardiovascular Systems

Dapagliflozin in HFrEF Patients Treated With Mineralocorticoid Receptor Antagonists An Analysis of DAPA-HF

Li Shen et al.

Summary: The study showed that the efficacy and safety of dapagliflozin were similar in patients with HFrEF taking or not taking an MRA, supporting the use of both drugs together.

JACC-HEART FAILURE (2021)

Article Peripheral Vascular Disease

Activation of Rac1-Mineralocorticoid Receptor Pathway Contributes to Renal Injury in Salt-Loaded db/db Mice

Daigoro Hirohama et al.

Summary: The study revealed that the activation of the Rac1-MR pathway contributes to the progression of DKD by causing hypertension and podocyte injury, highlighting MR antagonism and Rac1 inhibition as a novel strategy for DKD treatment.

HYPERTENSION (2021)

Review Chemistry, Medicinal

Role of mineralocorticoid receptor antagonists in kidney diseases

Vishal Patel et al.

Summary: Mineralocorticoid receptor antagonists, such as spironolactone and eplerenone, have shown therapeutic effects in treating hypertension and chronic kidney disease. New generation nonsteroidal MRAs like esaxerenone have lower risk of hyperkalemia and may provide optimal therapeutic benefits for patients with kidney diseases.

DRUG DEVELOPMENT RESEARCH (2021)

Article Multidisciplinary Sciences

Decoding myofibroblast origins in human kidney fibrosis

Christoph Kuppe et al.

Summary: Using single-cell RNA sequencing, researchers profiled the transcriptomes of healthy and fibrotic human kidneys, identifying distinct subpopulations of pericytes and fibroblasts as the main sources of scar-forming myofibroblasts during kidney fibrosis. This study shed light on the cellular origins and differentiation of myofibroblasts in human kidney fibrosis, identifying potential therapeutic targets such as NKD2.

NATURE (2021)

Article Peripheral Vascular Disease

Screening Rates for Primary Aldosteronism in Resistant Hypertension

Gilad Jaffe et al.

HYPERTENSION (2020)

Review Urology & Nephrology

Acute kidney injury and maladaptive tubular repair leading to renal fibrosis

Samuel M. -W. Yu et al.

CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION (2020)

Article Multidisciplinary Sciences

Cell profiling of mouse acute kidney injury reveals conserved cellular responses to injury

Yuhei Kirita et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Article Medicine, General & Internal

Effect of Finerenone on Chronic Kidney Disease Outcomes in Type 2 Diabetes

George L. Bakris et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Review Cardiac & Cardiovascular Systems

Targeting PAI-1 in Cardiovascular Disease: Structural Insights Into PAI-1 Functionality and Inhibition

Machteld Sillen et al.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2020)

Article Neurosciences

RAAS inhibitors directly reduce diabetes-induced renal fibrosis via growth factor inhibition

Sandor Koszegi et al.

JOURNAL OF PHYSIOLOGY-LONDON (2019)

Article Medicine, Research & Experimental

TGF-β promotes fibrosis after severe acute kidney injury by enhancing renal macrophage infiltration

Sungjin Chung et al.

JCI INSIGHT (2018)

Article Urology & Nephrology

Blocking TGF-β and β-Catenin Epithelial Crosstalk Exacerbates CKD

Stellor Nlandu-Khodo et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2017)

Article Urology & Nephrology

Tubulointerstitial fibrosis can sensitize the kidney to subsequent glomerular injury

Beom Jin Lim et al.

KIDNEY INTERNATIONAL (2017)

Article Multidisciplinary Sciences

PAI-1 is a critical regulator of FGF23 homeostasis

Mesut Eren et al.

SCIENCE ADVANCES (2017)

Article Medicine, General & Internal

The Spectrum of Subclinical Primary Aldosteronism and Incident Hypertension A Cohort Study

Jenifer M. Brown et al.

ANNALS OF INTERNAL MEDICINE (2017)

Review Cardiac & Cardiovascular Systems

2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure

Piotr Ponikowski et al.

EUROPEAN HEART JOURNAL (2016)

Letter Medicine, General & Internal

PATHWAY-2: spironolactone for resistant hypertension Reply

Bryan Williams et al.

LANCET (2016)

Review Urology & Nephrology

TGF-β: the master regulator of fibrosis

Xiao-ming Meng et al.

NATURE REVIEWS NEPHROLOGY (2016)

Review Medicine, Research & Experimental

Therapeutic targeting of aldosterone: a novel approach to the treatment of glomerular disease

Andrew S. Brem et al.

CLINICAL SCIENCE (2015)

Article Medicine, General & Internal

Effect of Finerenone on Albuminuria in Patients With Diabetic Nephropathy A Randomized Clinical Trial

George L. Bakris et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2015)

Article Urology & Nephrology

GM-CSF Promotes Macrophage Alternative Activation after Renal Ischemia/Reperfusion Injury

Sarah C. Huen et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2015)

Review Urology & Nephrology

Contribution of aldosterone to cardiovascular and renal inflammation and fibrosis

Nancy J. Brown

NATURE REVIEWS NEPHROLOGY (2013)

Review Urology & Nephrology

Renal interstitial fibrosis: mechanisms and evaluation

Alton B. Farris et al.

CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION (2012)

Article Urology & Nephrology

Aldosterone-Induced Fibrosis in the Kidney: Questions and Controversies

Andrew S. Brem et al.

AMERICAN JOURNAL OF KIDNEY DISEASES (2011)

Article Peripheral Vascular Disease

Aldosterone/NaCl-induced renal and cardiac fibrosis is modulated by TGF-β responsiveness of T cells

Barbara Schreier et al.

HYPERTENSION RESEARCH (2011)

Article Urology & Nephrology

Distinct Macrophage Phenotypes Contribute to Kidney Injury and Repair

Sik Lee et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2011)

Article Peripheral Vascular Disease

Mineralocorticoid Receptors, Salt-Sensitive Hypertension, and Metabolic Syndrome

Toshiro Fujita

HYPERTENSION (2010)

Article Medicine, Research & Experimental

Myeloid mineralocorticoid receptor controls macrophage polarization and cardiovascular hypertrophy and remodeling in mice

Michael G. Usher et al.

JOURNAL OF CLINICAL INVESTIGATION (2010)

Article Urology & Nephrology

Aldosterone Activates NF-kappa B in the Collecting Duct

Valerie Leroy et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2009)

Article Biochemistry & Molecular Biology

Modification of mineralocorticoid receptor function by Rac1 GTPase: implication in proteinuric kidney disease

Shigeru Shibata et al.

NATURE MEDICINE (2008)

Article Cardiac & Cardiovascular Systems

Aldosterone synthase inhibitor ameliorates angiotensin II - Induced organ damage

A Fiebeler et al.

CIRCULATION (2005)

Article Urology & Nephrology

Aldosterone/salt induces renal inflammation and fibrosis in hypertensive rats

ER Blasi et al.

KIDNEY INTERNATIONAL (2003)

Review Immunology

Transforming growth factor-beta in T-cell biology

L Gorelik et al.

NATURE REVIEWS IMMUNOLOGY (2002)

Article Endocrinology & Metabolism

Aldosterone: A mediator of myocardial necrosis and renal arteriopathy

R Rocha et al.

ENDOCRINOLOGY (2000)