期刊
DIABETES & METABOLISM JOURNAL
卷 46, 期 2, 页码 198-221出版社
KOREAN DIABETES ASSOC
DOI: 10.4093/dmj.2021.0347
关键词
Diabetes mellitus; type 2; Diabetic neuropathies; Diet; high-fat; Models; animal; genetic; Peripheral nerves; Rats; Streptozotocin
资金
- NHMRC, Australia [1126929]
- NHRMC Fellowship (NHMRC, Australia) [1091006]
- UNSW Sydney
- National Health and Medical Research Council of Australia [1091006, 1126929] Funding Source: NHMRC
This review examines the phenotyping of DPN in rat models of T2DM against the 'Neurodiab' criteria and discusses how DPN phenotypes differ between models, diabetes duration, and sex. Despite the introduction of Neurodiab guidelines, the use of diet and chemically induced T2DM models has surpassed that of transgenic models in recent years, with no substantial increase in the number of studies assessing all key DPN endpoints. The recommendation is to adhere to Neurodiab guidelines for creating better animal models of DPN to accelerate translation and drug development.
Diabetic peripheral neuropathy (DPN) affects over half of type 2 diabetes mellitus (T2DM) patients, with an urgent need for effective pharmacotherapies. While many rat and mouse models of T2DM exist, the phenotyping of DPN has been challenging with inconsistencies across laboratories. To better characterize DPN in rodents, a consensus guideline was published in 2014 to accelerate the translation of preclinical findings. Here we review DPN phenotyping in rat models of T2DM against the 'Neurodiab' criteria to identify uptake of the guidelines and discuss how DPN phenotypes differ between models and according to diabetes duration and sex. A search of PubMed, Scopus and Web of Science databases identified 125 studies, categorised as either diet and/ or chemically induced models or transgenic/spontaneous models of T2DM. The use of diet and chemically induced T2DM models has exceeded that of transgenic models in recent years, and the introduction of the Neurodiab guidelines has not appreciably increased the number of studies assessing all key DPN endpoints. Combined high-fat diet and low dose streptozotocin rat models are the most frequently used and well characterised. Overall, we recommend adherence to Neurodiab guidelines for creating better animal models of DPN to accelerate translation and drug development.
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