期刊
PHARMACEUTICS
卷 14, 期 6, 页码 -出版社
MDPI
DOI: 10.3390/pharmaceutics14061169
关键词
bioactive glass; tissue engineering; drug delivery; ceria
资金
- Executive Agency for Higher Education, Research, Development and Innovation Funding (UEFISCDI) [PN-III-P2-2.1-PED-2019-0598, 258 PED/2020]
A cerium-containing MBG-derived biomaterial scaffold was synthesized and characterized using various techniques. The results showed that the scaffold had good cytocompatibility and potential applications in bone tissue engineering.
Finding innovative solutions to improve the lives of people affected by trauma, bone disease, or aging continues to be a challenge worldwide. Tissue engineering is the most rapidly growing area in the domain of biomaterials. Cerium-containing MBG-derived biomaterials scaffolds were synthesized using polymethyl methacrylate (PMMA) as a sacrificial template. The obtained scaffolds were characterized by X-ray powder diffraction (XRPD), infrared spectroscopy (FTIR), and scanning electron microscopy (SEM). The Ce4+/Ce3+ ratio in the scaffolds was estimated. In vitro testing revealed good cytocompatibility of the investigated scaffolds in mouse fibroblast cell line (NCTC clone L929). The results obtained regarding bioactivity, antibacterial activity, and controlled drug delivery functions recommend these scaffolds as potential candidates for bone tissue engineering applications.
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