4.7 Article

Development of Tea Seed Oil Nanostructured Lipid Carriers and In Vitro Studies on Their Applications in Inducing Human Hair Growth

期刊

PHARMACEUTICS
卷 14, 期 5, 页码 -

出版社

MDPI
DOI: 10.3390/pharmaceutics14050984

关键词

tea seed oil; nanostructured lipid carriers; human follicle dermal papilla; natural ingredient; spreadability; texture analysis; hair serum

资金

  1. Chaipattana Foundation
  2. National Nanotechnology Center (NANOTEC)
  3. Supapan Seraphin (Profession Authorship Center, NSTDA)
  4. Research Center of Pharmaceutical Nanotechnology, Chiang Mai University, Thailand

向作者/读者索取更多资源

This study developed nanostructured lipid carriers loaded with tea seed oil, which showed better nontoxicity and growth-stimulating effect on human follicle dermal papilla cells compared to the intact oil. The nanoformulations exhibited excellent stability and improved spreadability in a hair serum formulation, reducing the sticky and greasy feeling after use.
Synthetic drugs used to treat hair loss cause many side-effects. Natural tea seed oil possesses many activities that can suppress hair loss. However, it is oily and sticky in direct application. In this study, tea seed oil loaded nanostructured lipid carriers (NLC) using Tween 80 (NLC-T), Varisoft 442 (NLC-V), and a combination of both surfactants (NLC-C) was developed. The obtained nanoformulations showed spherical particles in the size range 130-430 nm. Particle size and size distribution of NLC-C and NLC-T after storage at 4, 25, and 40 degrees C for 90 days were unchanged, indicating their excellent stability. The pH of NLC-T, NLC-V, and NLC-C throughout 90 days remained at 3, 4, and 3.7, respectively. NLC-C showed significantly greater nontoxicity and growth-stimulating effect on human follicle dermal papilla (HFDP) cells than the intact oil. NLC-T and NLC-V could not stimulate cell growth and showed high cytotoxicity. NLC-C showed melting point at 52 +/- 0.02 degrees C and its entrapment efficiency was 96.26 +/- 2.26%. The prepared hair serum containing NLC-C showed better spreading throughout the formulation than that containing the intact oil. Using 5% NLC-C showed a 78.8% reduction in firmness of the hair serum while enhancing diffusion efficiency by reducing shear forces up to 81.4%. In conclusion, the developed NLC-C of tea seed oil is an effective alternative in stimulating hair growth. Hair serum containing NLC-C obviously reduces sticky, oily, and greasy feeling after use.

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