期刊
PHARMACEUTICS
卷 14, 期 4, 页码 -出版社
MDPI
DOI: 10.3390/pharmaceutics14040834
关键词
fixed-dose combination (FDC); bilayer; multilayer tablets; gastric retention of oral dosage forms; hot-melt extrusion; three-dimensional (3D) printing; history of innovative forms
资金
- Ministry of Science and Higher Education [DWD/4/56/2020]
This article introduces the development of innovative forms of combination drugs and the application of various formulation technologies, including bilayer system, multilayer tablet, active film coating, hot-melt extrusion, and 3D printing. It also discusses the technological issues and challenges in the development of combination drugs, and summarizes the range of dosage forms made using these technologies over the past 30 years.
The development of innovative forms of combination drugs is closely related to the invention of the multilayer tablet press, polymers for pharmaceutical applications, the hot-melt extrusion process, and 3D printing in the pharmaceutical industry. However, combining multiple drugs within the same dosage form can bring many physicochemical and pharmacodynamic interactions. More and more new forms of fixed-dose combinations (FDCs) have been developed due to work to overcome the incompatibility of active substances or to obtain different drug release profiles in the same dosage form. This review provides discussions of the application of various innovation formulation technologies of FDC drugs such as bilayer system, multilayer tablet, active film coating, hot-melt extrusion, and 3D printing, taking into account the characteristics of the key ingredients in the FDC formulation and presenting technological problems and challenges related to the development of combination drugs. Moreover, the article summarizes the range of dosage forms that have been made using these technologies over the past 30 years.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据