期刊
PHARMACEUTICS
卷 14, 期 3, 页码 -出版社
MDPI
DOI: 10.3390/pharmaceutics14030514
关键词
immune thrombocytopenia (ITP); pregnancy; thrombopoietin receptor agonists (TPO-RAs); romiplostim
This study examined the effects of romiplostim, a form of thrombopoietin receptor agonist, on pregnant mice. The results showed that romiplostim increased platelet and megakaryocyte counts in pregnant mice and fetuses at doses above 10 mu g/kg. However, the clinically used dose for ITP patients did not have any adverse effects on pregnant mice.
Thrombopoietin receptor agonists (TPO-RAs) are an effective treatment for refractory immune thrombocytopenia (ITP). However, the use of TPO-RAs is limited for ITP in pregnant women due to concerns about fetal toxicity. In this study, we examined the effects of romiplostim, one of the TPO-RAs, on pregnant mice. The mice were injected subcutaneously with romiplostim (1, 5, 10, 30, and 100 mu g/kg) on gestational days (GD) 1, 8, and 15. We evaluated maternal and fetal platelet and megakaryocyte counts (MK), fetal weight at birth, placental morphology, and miscarriage rates. Romiplostim increased platelet and MK counts in pregnant mice at all doses and in fetuses at doses above 10 mu g/kg. Fetal weight at birth was slightly reduced at a dose of 100 mu g/kg, but there were no significant differences in placental weight, spiral artery wall thickness, placental growth factor signal changes, or the rate of resorption at that dosage. The dose of romiplostim used clinically for ITP patients (1-10 mu g/kg) did not show any adverse effects on pregnant mice. Although the results of the present study are encouraging, until there are more conclusive data, the use of romiplostim should be evaluated individually in severe, life-threatening cases, and all relevant ethical aspects should be considered.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据