期刊
PHARMACEUTICS
卷 14, 期 3, 页码 -出版社
MDPI
DOI: 10.3390/pharmaceutics14030560
关键词
nanogels; gold nanorod; cisplatin; doxorubicin; chemo- and photothermal therapy
资金
- National Council of Science and Technology of Mexico (CONACyT) [2016-CB-285419]
Dual-function nanogels synthesized via surfactant-free emulsion polymerization can act as smart carriers for synergistic chemo- and photothermal therapy. Galacto-functionalized nanogels exhibit efficient drug release ability in in vitro experiments. Additionally, the presence of gold nanorods leads to enhanced drug release under laser irradiation.
Dual-function nanogels (particle size from 98 to 224 nm) synthesized via surfactant-free emulsion polymerization (SFEP) were tested as smart carriers toward synergistic chemo- and photothermal therapy. Cisplatin (CDDP) or doxorubicin (DOX) and gold nanorods (GNRDs) were loaded into galacto-functionalized PNVCL-based nanogels, where the encapsulation efficiency for CDDP and DOX was around 64 and 52%, respectively. PNVCL-based nanogels were proven to be an efficient delivery vehicle under conditions that mimic the tumor site in vitro. The release of CDDP or DOX was slower at pH 7.4 and 37 degrees C than at tumor conditions of pH 6 and 40 degrees C. On the other hand, in the systems with GNRDs at pH 7.4 and 37 degrees C, the sample was irradiated with a 785 nm laser for 10 min every hour, obtaining that the release profiles were even higher than in the conditions that simulated a cancer tissue (without irradiation). Thus, the present study demonstrates the synergistic effect of chemo- and photothermal therapy as a promising dual function in the potential future use of PNVCL nanogels loaded with GNRDs and CDDP/DOX to achieve an enhanced chemo/phototherapy in vivo.
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