期刊
PHARMACEUTICS
卷 14, 期 4, 页码 -出版社
MDPI
DOI: 10.3390/pharmaceutics14040797
关键词
drug nanocrystals; active targeting; drug delivery; cancer
资金
- Shanghai Sailing Program [20YF1404500]
- Scientific Research Foundation of Huashan Hospital, Fudan University [2019QD012]
- Shanghai Education Commission Major Project [2017-01-07-00-07-E00052]
- National Natural Science Foundation of China [81773657, 81903547]
Drug nanocrystals can enhance the solubility and bioavailability of poorly water-soluble drugs, and active tumor-targeted drug delivery systems can improve the efficacy and safety of chemotherapy.
Drug nanocrystals, which are comprised of active pharmaceutical ingredients and only a small amount of essential stabilizers, have the ability to improve the solubility, dissolution and bioavailability of poorly water-soluble drugs; in turn, drug nanocrystal technology can be utilized to develop novel formulations of chemotherapeutic drugs. Compared with passive targeting strategy, active tumor-targeted drug delivery, typically enabled by specific targeting ligands or molecules modified onto the surface of nanomedicines, circumvents the weak and heterogeneous enhanced permeability and retention (EPR) effect in human tumors and overcomes the disadvantages of nonspecific drug distribution, high administration dosage and undesired side effects, thereby contributing to improving the efficacy and safety of conventional nanomedicines for chemotherapy. Continuous efforts have been made in the development of active tumor-targeted drug nanocrystals delivery systems in recent years, most of which are encouraging and also enlightening for further investigation and clinical translation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据