4.7 Article

Associations between the C3orf20 rs12496846 Polymorphism and Both Postoperative Analgesia after Orthognathic and Abdominal Surgeries and C3orf20 Gene Expression in the Brain

期刊

PHARMACEUTICS
卷 14, 期 4, 页码 -

出版社

MDPI
DOI: 10.3390/pharmaceutics14040727

关键词

opioids; analgesics; single-nucleotide polymorphisms; orthognathic surgery; abdominal surgery

资金

  1. Japan Society for the Promotion of Science (JSPS) KAKENHI [22790518, 23390377, 24790544, 26293347, JP16H06276, 17H04324, 17K08970, 18K08829, 20K09259, 21H03028]
  2. Ministry of Health, Labour, and Welfare (MHLW) of Japan [H26-Kakushintekigan-ippan-060]
  3. Japan Agency for Medical Research and Development (AMED) [JP19ek0610011, JP19dk0307071]
  4. Smoking Research Foundation (Tokyo, Japan)
  5. Japan Research Foundation for Clinical Pharmacology (JRFCP)
  6. Japan Society for the Promotion of Science (JSPS) KAKENHI

向作者/读者索取更多资源

Considerable individual differences are observed in the sensitivity to opioid analgesics. A study found that carriers of the G allele of the rs12496846 SNP in the C3orf20 gene region were significantly associated with higher postoperative analgesic requirements, and this SNP was also associated with the mRNA expression level of the C3orf20 gene.
Considerable individual differences are widely observed in the sensitivity to opioid analgesics. We focused on rs12496846, rs698705, and rs10052295 single-nucleotide polymorphisms (SNPs) in the C3orf20, SLC8A2, and CTNND2 gene regions that we previously identified as possibly associated with postoperative analgesia after orthognathic surgery. We investigated associations between these SNPs and postoperative analgesia in 112 patients who underwent major open abdominal surgery in hospitals and were treated with analgesics, including opioids, after surgery. Total genomic DNA was extracted from peripheral blood or oral mucosa samples for genotyping each SNP. Effects of these potent SNPs on gene expression in the brain were also investigated in samples that were provided by the Stanley Foundation Brain Bank. In the association studies, carriers of the G allele of the rs12496846 SNP in the C3orf20 gene region were significantly associated with greater 24 h postoperative analgesic requirements among the three SNPs that were investigated (p = 0.0015), which corroborated a previous study of orthognathic patients (p < 0.0001). In the gene expression analysis, carriers of the G allele of the rs12496846 SNP were significantly associated with lower mRNA expression of the C3orf20 gene (p < 0.0001). These results indicate that this SNP could serve as a marker that predicts analgesic requirements.

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