期刊
PHARMACEUTICS
卷 14, 期 5, 页码 -出版社
MDPI
DOI: 10.3390/pharmaceutics14050985
关键词
anti-inflammatory; drug delivery; loading efficiency; rheumatoid arthritis; silica nanoparticles; sustained release
资金
- Korea Technology and Information Promotion Agency of SMEs (TIPA) - Ministry of SMEs and Startups [S3109193]
- National Research Foundation (NRF) - Ministry of Science and ICT of Korea [NRF-2020R1A2C110189112]
- Korea Technology & Information Promotion Agency for SMEs (TIPA) [S3109193] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
This study proposes radially mesoporous silica nanoparticles as a carrier for dexamethasone, achieving sustained anti-inflammatory effects in rheumatoid arthritis. The nanoparticles demonstrate high-capacity loading and sustained release of the drug, resulting in improved delivery efficiency compared to traditional silica nanoparticles. In vivo evaluation confirms the sustained anti-inflammatory effects and cartilage recovery in a rat model of the disease.
Radially mesoporous silica nanoparticles (RMSNs) with protonated amine functionality are proposed to be a dexamethasone (Dex) carrier that could achieve a sustained anti-inflammatory effect in rheumatoid arthritis (RA). High-capacity loading and a sustained release of target drugs were achieved by radially oriented mesopores and surface functionality. The maximum loading efficiency was confirmed to be about 76 wt%, which is about two times greater than that of representative mesopores silica, SBA-15. In addition, Dex-loaded RMSNs allow a sustained-release profile with about 92% of the loaded Dex for 100 h in vitro, resulting in 2.3-fold better delivery efficiency of Dex than that of the SBA-15 over the same period. In vivo evaluation of the inhibitory effects on inflammation in a RA disease rat model showed that, compared with the control groups, the group treated with Dex-loaded RMSNs sustained significant anti-inflammatory effects and recovery of cartilage over a period of 8 weeks. The in vivo effects were confirmed via micro-computed tomography, bone mineral density measurements, and modified Mankin scoring. The proposed Dex-loaded RMSNs prolonged the life of the in vivo concentrations of therapeutic agents and maximized their effect, which should encourage its application.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据