期刊
FRONTIERS IN ONCOLOGY
卷 12, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fonc.2022.889017
关键词
gastric cancer; antibody-drug conjugates; targeted therapy; HER2; drug resistance
类别
资金
- National Natural Science Foundation of China [81403220]
- National Key Research and Development (RD) Plan [2018YFC1707400]
- Tianjin Health and Family Planning-High Level Talent Selection and Training Project
Gastric cancer is a prevalent and difficult-to-treat malignant tumor. Antibody-drug conjugates hold promise as a novel therapeutic option, but drug resistance is a challenge.
Gastric cancer is an intractable malignant tumor that has the fifth highest morbidity and the third highest mortality in the world. Even though various treatment options did much to ameliorate the prognosis of advanced gastric cancer, the survival time remained unsatisfactory. It is significant to develop new therapeutic agents to improve the long-term outcome. Antibody-drug conjugate is an innovative and potent antineoplastic drug composed of a specifically targeted monoclonal antibody, a chemical linker, and a small molecule cytotoxic payload. Powerful therapeutic efficacy and moderate toxicity are its preponderant advantages, which imply the inevitable pharmaceutical developments to meet the demand for individualized precision therapy. Nevertheless, it is unavoidable that there is a phenomenon of drug resistance in this agent. This article systematically reviewed the recent progress of antibody-drug conjugates in advanced gastric cancer therapy.
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