期刊
FRONTIERS IN ONCOLOGY
卷 12, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fonc.2022.841381
关键词
PRMT6; arginine methylation; cancers; regulation; PRMT6 inhibitors
类别
资金
- National Natural Science Foundation of China [81971394, 81571457]
- Shanghai Pujiang Program [15PJ1400900]
Protein arginine methyltransferase 6 (PRMT6) is involved in the epigenetic regulation of gene expression and plays various roles in different cancers. It has been identified as a potential therapeutic target for anti-tumor treatment. This review summarizes the current understanding of PRMT6's function, structure, and its role in cancer, as well as the mechanisms behind its effects.
Protein arginine methyltransferase 6 (PRMT6) is a type I PRMT that is involved in epigenetic regulation of gene expression through methylating histone or non-histone proteins, and other processes such as alternative splicing, DNA repair, cell proliferation and senescence, and cell signaling. In addition, PRMT6 also plays different roles in various cancers via influencing cell growth, migration, invasion, apoptosis, and drug resistant, which make PRMT6 an anti-tumor therapeutic target for a variety of cancers. As a result, many PRMT6 inhibitors are being utilized to explore their efficacy as potential drugs for various cancers. In this review, we summarize the current knowledge on the function and structure of PRMT6. At the same time, we highlight the role of PRMT6 in different cancers, including the differentiation of its promotive or inhibitory effects and the underlying mechanisms. Apart from the above, current research progress and the potential mechanisms of PRMT6 behind them were also summarized.
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